Recombinant Human FGFR1OP Protein (His&GST Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2060
Recombinant Human FGFR1OP Protein (His&GST Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2060
Product Overview
| Tag | His&GST |
| Host Species | Human |
| Accession | AAH11902.1 |
| Synonym | FGFR1 Oncogene Partner, FOP, Fibroblast Growth Factor Receptor 1 Oncogene Partner |
| Background | FGFR1OP (FGFR1 Oncogene Partner) is a Protein Coding gene. Diseases associated with FGFR1OP include Graves' Disease and Crohn's Disease. Among its related pathways are HIV Life Cycle and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase binding.This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. |
| Description | A DNA sequence encoding the human FGFR1OP ( Ala2-Ala379) was expressed with the N-terminal His-tagged GST tag at the N-terminus. |
| Source | Insect Cells |
| Predicted N Terminal | Met |
| AA Sequence | Ala2-Ala379 |
| Molecular Weight | The secreted recombinant human FGFR1OP consists of 615 amino acids and predicts a molecular mass of 68.6 KDa. The apparent molecular mass of the protein is approximately 69 KDa in SDS-PAGE under reducing conditions due to glycosylation. |
| Purity | >85% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Recombinant Human FGFR1OP Protein (His&GST Tag) was lyophilized from sterile 50mM Tris, 100mM NaCl, 10% glycerol, pH 8.0. |
| Stability | Recombinant Human FGFR1OP protein is stable up to 1 year at -70°C |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
