Recombinant Human FCMR Protein

Beta LifeScience SKU/CAT #: BL-3813PS
Recombinant Human FCMR Protein

Recombinant Human FCMR Protein

Beta LifeScience SKU/CAT #: BL-3813PS
Catalog No.: BL-3813PS

Product Overview

Tag His
Host Species Human
Synonym Fas apoptotic inhibitory molecule 3, IgM Fc fragment receptor, Regulator of Fas-induced apoptosis Toso, FAIM3, TOSO.
Background Fas apoptotic inhibitory molecule 3 or FCMR takes part in processes occurring within the immune system. The FCMR is protecting cells from apoptosis that is induced by FADD, FAS and TNF alpha proteins, without over expressing inhibitors of apoptosis such as BCLXL or BCL2. FCMR activates an inhibitory pathway that inhibits CASP8 activation, instead of blocking apoptotic signals downstream.
Description FCMR Human Recombinant expressed in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 18-250) containing 243a.a. including a 10 a.a N-terminal His tag. The total molecular weight is 27.2kDa (calculated).
Source E.coli
AA Sequence MKHHHHHHAS RILPEVKVEG ELGGSVTIKC PLPEMHVRIY LCREMAGSGT CGTVVSTTNF IKAEYKGRVT LKQYPRKNLF LVEVTQLTES DSGVYACGAG MNTDRGKTQK VTLNVHSEYE PSWEEQPMPE TPKWFHLPYL FQMPAYASSS KFVTRVTTPA QRGKVPPVHH SSPTTQITHR PRVSRASSVA GDKPRTFLPS TTASKISALE GLLKPQTPSY NHHTRLHRQR ALDYGSQSGR EGQ.
Purity >95.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation FCMR filtered (0.4 µm) and lyophilized from 0.5mg/ml in 50mM acetate buffer, pH 4.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
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