Recombinant Human ETHE1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1943
Recombinant Human ETHE1 Protein (His Tag)

Recombinant Human ETHE1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1943
Catalog No.: BLPSN-1943

Product Overview

Tag His
Host Species Human
Accession O95571
Synonym HSCO, YF13H12
Background ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. ETHE1 can suppresses p53-induced apoptosis by preventing nuclear localization of RELA. Mutations in ETHE1 gene result in ethylmalonic encephalopathy. Ethylmalonic encephalopathy is an autosomal recessive, invariably fatal disorder characterized by early-onset encephalopathy, microangiopathy, chronic diarrhea, defective cytochrome c oxidase (COX) in muscle and brain, high concentrations of C4 and C5 acylcarnitines in blood and high excretion of ethylmalonic acid in urine.
Description A DNA sequence encoding the human ETHE1 (O95571) (Leu13-Ala254) was expressed with a His tag at the N-terminus.
Source E.coli
Predicted N Terminal His
AA Sequence Leu13-Ala254
Molecular Weight The recombinant human ETHE1 consists of 257 a.a. and predicts a molecular mass of 28.3 KDa. It migrates as an approximately 28 KDa band in SDS-PAGE under reducing conditions.
Purity >90% as determined by SDS-PAGE
Endotoxin Please contact us for more information.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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