Recombinant Human Eotaxin-2 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1775
Recombinant Human Eotaxin-2 Protein (His Tag)

Recombinant Human Eotaxin-2 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1775

Product Overview

Tag His
Host Species Human
Accession O00175
Synonym Ckb-6, MPIF-2, MPIF2, SCYA24
Background CCL24, also known as Eotaxin-2 and MPIF-2, belongs to the intercrine beta (chemokine CC) family. CCL24 gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL24 displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. CCL24 is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. CCL24 is chemotactic for resting T-lymphocytes, and eosinophils. It has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. It is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Eotaxin-2 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. Elevated level of Eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease.
Description A DNA sequence encoding the human CCL24 (O00175) (Met 1-Cys 119) was fused with a His tag at the C-terminus.
Source Baculovirus-Insect Cells
Predicted N Terminal Val 27
AA Sequence Met 1-Cys 119
Molecular Weight The secreted recombinant human CCL24 consists of 103 a.a. and predicts a molecular mass of 11.8 kDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions.
Purity >87% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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