Recombinant Human Endostatin Protein

Beta LifeScience SKU/CAT #: BL-3791PS
Recombinant Human Endostatin Protein

Recombinant Human Endostatin Protein

Beta LifeScience SKU/CAT #: BL-3791PS
Catalog No.: BL-3791PS

Product Overview

Tag N/A
Host Species Human
Background Once a cluster of cancer cells reaches a diameter of about 1-2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen and nutrients and to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels (angiogenesis), which are vital for the growth and persistence of solid tumors and their metastases.The production of several angiogenic factors (FGF-a, FGF-b, VEGF and VPF) is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin and thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive and negative regulators of neovascularization mentioned above. Endostatin's role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor.
Description Endostatin Human Recombinant expressed in E.Coli is a single, non-glycosylated, polypeptide having a predicted molecular weight of 20kDa.C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Induces tyrosine phosphorylation of Shc (SH2 domain adapter protein) leading to specific inhibition in endothelial cell proliferation.The Endostatin is purified by unique purification methods.
Source E.coli
Purity >95.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Bioactivity The activity was found to be 16,000IU/mg.
Formulation The recombinant Human Endostatin is formulated with 30mM Sodium acetate buffer and Mannitol, pH-5.5.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Endostatin should be stored at 2-8°C.Do NOT Freeze!
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