Recombinant Human DR3 Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-1651
Recombinant Human DR3 Protein (Fc Tag)

Recombinant Human DR3 Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-1651
Catalog No.: BLPSN-1651

Product Overview

Tag Fc
Host Species Human
Accession NP_003781.1
Synonym APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR
Background Tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), also known as Death receptor 3 (DR3) or TNFRSF12 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. TNFRSF25/DR3/TNFRSF12 has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this TNFRSF25 encoding gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
Description A DNA sequence encoding the human TNFRSF25 (NP_683867.1) (Met1-Gln199) was expressed with the Fc region of human IgG1 at the C-terminus.
Source HEK293
Predicted N Terminal Gln 25
AA Sequence Met1-Gln199
Molecular Weight The recombinant human TNFRSF25 consists of 416 a.a. and predicts a molecular mass of 45.9 kDa.
Purity >95% as determined by SDS-PAGE.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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