Recombinant Human Doppel Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1639
Recombinant Human Doppel Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1639
Catalog No.: BLPSN-1639
Product Overview
| Tag | Fc |
| Host Species | Human |
| Accession | NP_036541.2 |
| Synonym | dJ1068H6.4, DOPPEL, DPL, PrPLP |
| Background | Doppel (PRND) is a paralogue of the mammalian prion (PRNP) gene. It is abundant in testis and, unlike PRNP, it is expressed at low levels in the adult central nervous system (CNS). Besides, doppel overexpression correlates with some prion-disease pathological features, such as ataxia and death of cerebellar neurons.Prion-related protein doppel gene (PRND), as an essential member of the mammalian prion gene family, is associated with the scrapie susceptibility as well as phenotype traits, so the genetic variation of the PRND has been highly concerned recently, including the single nucleiotide polymorphism (SNP) and insertion/deletion (indel). |
| Description | A DNA sequence encoding the human PRND (NP_036541.2) (Met1-Gly152) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Arg 27 |
| AA Sequence | Met1-Gly152 |
| Molecular Weight | The recombinant human PRND consists 364 a.a. and predicts a molecular mass of 41.2 kDa. |
| Purity | >95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
