Recombinant Human Desmocollin 2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1614
Recombinant Human Desmocollin 2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1614
Collections: Other recombinant proteins, Recombinant proteins
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Human |
Accession | Q02487 |
Synonym | ARVD11, CDHF2, DG2, DGII/III, DSC3 |
Background | DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Like other desmocollins, murine DSC2 has two products, Dsc2a and Dsc2b, produced by alternative splicing of a 46 bp exon which encodes 11 COOH-terminal aa followed by an in-frame stop codon. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 65 kb combined. Mutations in DSC2 are associated with arrhythmogenic right ventricular dysplasia-11. DSC2 is Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 may contribute to epidermal cell positioning by mediating differential adhesiveness between cells that express different isoforms. |
Description | A DNA sequence encoding the extracellular domain (Met 1-Arg 684) of human DSC2 (Q02487-1) was expressed, with a C-terminal His tag. |
Source | HEK293 |
Predicted N Terminal | Ala 28 & Arg 136 |
AA Sequence | Met 1-Arg 684 |
Molecular Weight | The secreted recombinant human DSC2 (pro form) consists of 668 a.a. and predicts a molecular mass of 75 kDa. As a result of glycosylation, the apparent molecular mass of rhDSC2 is approximately 85 and 100 kDa in SDS-PAGE under reducing conditions, corresponding to the mature and pro form respectively. |
Purity | >75% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |