Recombinant Human Decorin Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1586
Recombinant Human Decorin Protein (His Tag)

Recombinant Human Decorin Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1586
Catalog No.: BLPSN-1586

Product Overview

Tag His
Host Species Human
Synonym CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B
Background Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles.
Description A DNA sequence encoding the human DCN (NP_077043.1 ) (Met1-Lys354) was expressed with a His tag at the C-terminus.
Source HEK293
Predicted N Terminal Gly 17
AA Sequence Met1-Lys354
Molecular Weight The recombinant human DCN consists of 349 a.a. and predicts a molecular mass of 39.5 kDa.
Purity >90% as determined by SDS-PAGE.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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