Name: Recombinant Human Decorin Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-1585
Availability: InStock

Recombinant Human Decorin Protein (His Tag)

Catalog No.: BLPSN-1585

Product Overview

Tag	His
Host Species	Human
Accession	NP_001911.1
Synonym	CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B
Background	Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles.
Description	A DNA sequence encoding the human Decorin (NP_001911.1) (Met 1-Lys 359) was expressed, with a His tag at the C-terminus.
Source	HEK293
Predicted N Terminal	Gly 17
AA Sequence	Met 1-Lys 359
Molecular Weight	The recombinant human Decorin consists of 354 a.a. and has a predicted molecular mass of 39.4 kDa. As a result of different glycosylation, the apparent molecular mass of rhDecorin is approximately 45 kDa or higher in SDS-PAGE under reducing conditions.
Purity	>95% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.