Recombinant Human Decorin Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-1584
Recombinant Human Decorin Protein (Fc Tag)

Recombinant Human Decorin Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-1584
Catalog No.: BLPSN-1584

Product Overview

Tag Fc
Host Species Human
Accession NP_001911.1
Synonym CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B
Background Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles.
Description A DNA sequence encoding the mature form of human Decorin (NP_001911.1) (Asp 31-Lys 359) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Source HEK293
Predicted N Terminal Glu 20
AA Sequence Asp 31-Lys 359
Molecular Weight The recombinant human Decorin/Fc is a disulfide-linked homodimer. The reduced monomer consists of 566 a.a. and has a predicted molecular mass of 63. kDa. As a result of glycosylation, rh Decorin/Fc monomer migrates as an approximately 70-75 kDa band in SDS-PAGE under reducing conditions.
Purity >95% as determined by SDS-PAGE and SEC-HPLC Analysis.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recently viewed