Recombinant Human Decorin Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1584
Recombinant Human Decorin Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1584
Catalog No.: BLPSN-1584
Product Overview
| Tag | Fc |
| Host Species | Human |
| Accession | NP_001911.1 |
| Synonym | CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B |
| Background | Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles. |
| Description | A DNA sequence encoding the mature form of human Decorin (NP_001911.1) (Asp 31-Lys 359) was expressed with the fused Fc region of human IgG1 at the N-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Glu 20 |
| AA Sequence | Asp 31-Lys 359 |
| Molecular Weight | The recombinant human Decorin/Fc is a disulfide-linked homodimer. The reduced monomer consists of 566 a.a. and has a predicted molecular mass of 63. kDa. As a result of glycosylation, rh Decorin/Fc monomer migrates as an approximately 70-75 kDa band in SDS-PAGE under reducing conditions. |
| Purity | >95% as determined by SDS-PAGE and SEC-HPLC Analysis. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
