Name: Recombinant Human Cystatin F / CMAP Protein
Brand: Beta LifeScience
SKU: BLPSN-1534
Availability: InStock

Recombinant Human Cystatin F / CMAP Protein

Catalog No.: BLPSN-1534

Product Overview

Tag	N/A
Host Species	Human
Accession	NP_003641.3
Synonym	CMAP
Background	The cystatin superfamily members are important natural cysteine protease inhibitors present in a wide variety of organisms and are divided into three classes. Cystatin F, also known as leukocystatin and CMAP (Cystatin-like Metastasis-Associated Protein), is a type 2 cystatin and its expression is limited to hematopoietic cells, with the highest expression levels being observed in monocytes, dendritic cells, and certain types of T-cells. Furthermore, cystatin F mRNA becomes up-regulated during dendritic cell maturation, and thus suggests a specific role of cystatin F in immune regulation. Cystatin F is produced as a dimer, an inactive cathepsin inhibitor which is activated by chemical reduction. In addition, Cystatin F and its homologues have been observed expressing in various human cancer cell lines established from malignant tumors, and thus indicates a new diagnosis and prevention approach of certain human carcinomas metastasis.
Description	The mature form of the human Cystatin F (NP_003641.3) (Met 1-His 145) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
Source	HEK293
Predicted N Terminal	Gly 20
AA Sequence	Met 1-His 145
Molecular Weight	The recombinant human Cystatin F consists of 132 a.a. and predicts a molecular mass of 15.2 kDa. As a result of glycosylation, the apparent molecular mass of rhCystatin F is approximately 25 kDa in SDS-PAGE.
Purity	>95% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.