Recombinant Human Cofilin Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1372
Recombinant Human Cofilin Protein (His Tag)

Recombinant Human Cofilin Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1372
Catalog No.: BLPSN-1372

Product Overview

Tag His
Host Species Human
Accession P23528
Synonym CFL, HEL-S-15
Background CFL1, also known as n-cofilin, is a member of the ADF/Cofilin family. This family comprises three genes: CFL1, CFL2 and DSTN (destrin). ADF/Cofilin family members bind G-actin monomers and depolymerize actin filaments through two mechanisms: severing and increasing the off-rate for actin monomers from the pointed end. Cofilin also binds with other proteins such as myosin, tropomyosin, alpha-actinin, gelsolin and scruin. These proteins compete with cofilin for actin binding. Сofilin also plays a role in innate immune response. CFL1 contains 1 ADF-H domain and is widely distributed in various tissues. It is important for normal progress through mitosis and normal cytokinesis.
Description A DNA sequence encoding the human CFL1 (P23528) (Met1-Leu166) was expressed with a His tag at the N-terminus.
Source E.coli
Predicted N Terminal His
AA Sequence Met1-Leu166
Molecular Weight The recombinant human CFL1 consists of 181 a.a. and predicts a molecular mass of 20.3 KDa. It migrates as an approximately 21 KDa band in SDS-PAGE under reducing conditions.
Purity >95% as determined by SDS-PAGE
Endotoxin Please contact us for more information.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile 50mM Tris, 100mM NaCl, 10% Glycerol, pH 8.0..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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