Recombinant Human Chymotrypsin-like protease / CTRL1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1268
Recombinant Human Chymotrypsin-like protease / CTRL1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1268
Catalog No.: BLPSN-1268
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | P40313 |
| Synonym | CTRL1 |
| Background | CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family. CTRL-1 contains 1peptidase S1 domain. Its expression is increased in preeclampsia (PE). Placental-derived chymotrypsin-like protease is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of cell adhesion molecule expressions, activation of cellular protease, and induction of extracellular regulated kinase phosphorylation. Activated microglia have been observed in various neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, and multiple sclerosis. Five structurally distinct inhibitors that are known to inhibit chymotrypsin-like proteases were partially protective. They might represent a novel class of drugs with benefit in diseases where overactivity of microglia contributes to the pathogenesis. |
| Description | A DNA sequence encoding the human CTRL (P40313) (Met1-Asn264) was expressed with a His tag at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Cys 19 |
| AA Sequence | Met1-Asn264 |
| Molecular Weight | The recombinant human CTRL consists of 257 a.a. and predicts a molecular mass of 27.6 KDa. It migrates as an approximately 35 and 32KDa band in SDS-PAGE under reducing conditions. |
| Purity | (36.0+62.4)% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
