Recombinant Human CHRNA6 Protein

Beta LifeScience SKU/CAT #: BL-3708PS
Recombinant Human CHRNA6 Protein

Recombinant Human CHRNA6 Protein

Beta LifeScience SKU/CAT #: BL-3708PS
Catalog No.: BL-3708PS

Product Overview

Tag N/A
Host Species Human
Synonym CHNRA6, Neuronal acetylcholine receptor subunit alpha-6, CHRNA6.
Background Cholinergic Receptor Nicotinic, Alpha 6 (CHRNA6) is a part of the nicotinic acetylcholine receptors (nAChRs) family. nAChRs are heteropentameric ligand-gated ion channels generating from the assembly of alpha and beta protein subunits. After binding acetylcholine, the AChRs respond by a major change in conformation which affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA6 receptors have a rather selective localization to the nigrostriatal pathway.
Description CHRNA6 Human Recombinant expressed in E.Coli is a single, non-glycosylated polypeptide chain containing 250a.a. (26-239 a.a) and having a molecular weight of 29.3kDa. CHRNA6 is fused to a 36a.a. His-tag at N-terminus and purified by unique purification methods.
Source E.coli
AA Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSKGCV GCATEERLFH KLFSHYNQFI RPVENVSDPV TVHFEVAITQ LANVDEVNQI METNLWLRHI WNDYKLRWDP MEYDGIETLR VPADKIWKPD IVLYNNAVGD FQVEGKTKAL LKYNGMITWT PPAIFKSSCP MDITFFPFDH QNCSLKFGSW TYDKAEIDLL IIGSKVDMND FWENSEWEII DASGYKHDIK YNCCEEIYTD ITYSFYIRRL.
Purity >85.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation CHRNA6 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
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