Name: Recombinant Human CCM2 Protein
Brand: Beta LifeScience
SKU: BL-3693PS
Availability: InStock

Catalog No.: BL-3693PS

Product Overview

Tag	N/A
Host Species	Human
Synonym	Cerebral Cavernous Malformation 2, C7orf22, malcavernin, CerebralCavernous Malformations 2 Protein, Chromosome 7 Open Reading Frame 22, OSM, MGC4067.
Background	CerebralCavernous Malformation 2, also known as CCM2 is a piece of the CCM signalingpathway which is a vital regulator of heart and vessel formation as well asintegrity. CCM2 performs through the stabilization of endothelial celljunctions. In addition, CCM2 functions as a scaffold protein for MAP2K3-MAP3K3signaling. CCM2 plays a key role in the modulation of MAP3K3-dependent p38activation induced by hyperosmotic shock. Mutations in CCM2 result in cerebralcavernous malformations. Multiple transcript variants encoding dissimilarisoforms have been discoveredfor CCM2.
Description	CCM2 Human Recombinant expressed in E.Coli is a single,non-glycosylated polypeptide chain containing 311a.a. (66-353 a.a) andhaving a molecular weight of 34.3kDa.CCM2 is fused to a 23a.a. His-tag at N-terminusand purified by unique purification methods.
Source	E.coli
AA Sequence	MGSSHHHHHH SSGLVPRGSH MGSEVKYLGQ LTSIPGYLNP SSRTEILHFI DNAKRAHQLP GHLTQEHDAVLSLSAYNVKL AWRDGEDIIL RVPIHDIAAV SYVRDDAAHL VVLKTDDSST KVDIKETYEV EASTFCFPESVDVGGASPHS KTISESELSA SATELLQDYM LTLRTKLSSQ EIQQFAALLH EYRNGASIHE FCINLRQLYG DSRKFLLLGL RPFIPEKDSQHFENFLETIG VKDGRGIITD SFGRHRRALS TTSSSTTNGN RATGSSDDRS APSEGDEWDR MISDISSDIEALGCSMDQDS A
Purity	Greaterthan 90.0% as determined by SDS-PAGE.
Endotoxin	<1.0 EU per μg by the LAL method.
Formulation	CCM2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol and1mM DTT.
Stability	Recombinant protein is stable for 12 months at -70°C
Usage	For Research Use Only
Storage	Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.