Recombinant Human CARHSP1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-0580
Recombinant Human CARHSP1 Protein (His Tag)

Recombinant Human CARHSP1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-0580
Catalog No.: BLPSN-0580

Product Overview

Tag His
Host Species Human
Accession Q9Y2V2
Synonym CRHSP-24, CSDC1
Background CARHSP1 is a biomarker for diabetic complications. Adenovirus-mediated CARHSP1 overexpression and siRNA-mediated knockdown experiments were performed to characterize the role of CARHSP1 in the regulation of gluconeogenic gene expression. CARHSP1 is regulated by nutrient status in the liver and functions at the transcriptional level to negatively regulate gluconeogenic genes, including the glucose-6-phosphatase catalytic subunit (G6Pc) and phosphoenolpyruvate carboxykinase 1 (PEPCK1). In addition, it is found that CARHSP1 can physically interact with peroxisome proliferator-activated receptor-alpha (PPARalpha) and inhibit its transcriptional activity. Both pharmacological and genetic ablations of PPARalpha attenuate the inhibitory effect of CARHSP1 on gluconeogenic gene expression in hepatocytes.
Description A DNA sequence encoding the human CARHSP1(Q9Y2V2 ) (Met1-Ser147) was expressed with a His tag at the N-terminus.
Source E.coli
Predicted N Terminal His
AA Sequence Met1-Ser147
Molecular Weight The recombinant human CARHSP1 consists of 162 a.a. and predicts a molecular mass of 17.7 KDa. It migrates as an approximately 21 KDa band in SDS-PAGE under reducing conditions.
Purity >85% as determined by SDS-PAGE
Endotoxin Please contact us for more information.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile 50mM Tirs, 10% Glycerol, 200mM NaCl, pH 8.0..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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