Recombinant Human C1D Protein (GST Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0477
Recombinant Human C1D Protein (GST Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0477
Collections: Other recombinant proteins, Recombinant proteins
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | GST |
Host Species | Human |
Accession | Q13901 |
Synonym | hC1D, LRP1, Rrp47, SUN-CoR, SUNCOR |
Background | C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a corepressor for the thyroid hormone receptor. It is thought that C1D nuclear receptor corepressor regulates TRAX/Translin complex formation. It is expressed in kidney, heart, brain, spleen, lung, testis, liver and small intestine. It plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. It potentiates transcriptional repression by NR1D1 and THRB. C1D nuclear receptor corepressorcan activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. It also can induce apoptosis in a p53/TP53 dependent manner. |
Description | A DNA sequence encoding the human C1D (Q13901) (Met 1-Ser 141) was fused with the GST tag at the N-terminus. |
Source | E.coli |
Predicted N Terminal | Met |
AA Sequence | Met 1-Ser 141 |
Molecular Weight | The recombinant human C1D/GST chimera consists of 375 a.a. and has a predicted molecular mass of 43.2 kDa. It migrates as an approximately 43 KDa band in SDS-PAGE under reducing conditions. |
Purity | >80% as determined by SDS-PAGE |
Endotoxin | Please contact us for more information. |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.5. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Target Details
Target Function | Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. |
Subcellular Location | Nucleus. Cytoplasm. Nucleus, nucleolus. |
Protein Families | C1D family |
Database References | |
Tissue Specificity | Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung an |
Gene Functions References
- C1D is associated with the DNA repair complex and may promote repair of ultraviolet irradiation-induced DNA damage. PMID: 20530579
- Results are consistent with a role for the exosome-associated protein C1D in the recruitment of the exosome to pre-rRNA to mediate the 3' end processing of the 5.8S rRNA. PMID: 17412707
- Anti-C1D autoantibodies were observed in patients with polymyositis-scleroderma overlap syndrome. PMID: 17599775
- TRAX enhances the DNA binding capacity of Translin, that binds to recombination regions in some malignancies. C1D interacts with TRAX following g-irradiation and prevents formation of TRAX/Translin complex, thereby inhibits any unwanted recombination. PMID: 11801738
- The C1D protein interacts with the catalytic subunit of DNA-PK and is a very effective substrate for DNA-PK in vitro. Moreover, C1D directs the activation of DNA-PK in a manner that does not require DNA termini, suggesting a role for C1D in DNA repair. PMID: 9679063