Name: Recombinant Human Asialoglycoprotein Receptor 1 / ASGPR1 Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-0280
Availability: InStock

Recombinant Human Asialoglycoprotein Receptor 1 / ASGPR1 Protein (His Tag)

Catalog No.: BLPSN-0280

Product Overview

Tag	His
Host Species	Human
Accession	P07306
Synonym	ASGPR, ASGPR1, CLEC4H1, HL-1
Background	The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.
Description	A DNA sequence encoding the human ASGR1 isoform 1 (P07306) (Gln 62-Leu 291) was expressed, with a His tag at the N-terminus.
Source	HEK293
Predicted N Terminal	His
AA Sequence	Gln 62-Leu 291
Molecular Weight	The recombinant human ASGR1 consists of 246 a.a. and has a calculated molecular mass of 28.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhASGR1 is approximately 37 kDa due to glycosylation.
Purity	>90% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.