Recombinant Human ASGR2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0279

Recombinant Human ASGR2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0279
Catalog No.: BLPSN-0279
Product Overview
Tag | His |
Host Species | Human |
Accession | P07307 |
Synonym | ASGP-R2, ASGPR2, CLEC4H2, HBXBP, HL-2 |
Background | ASGR2 is a subunit of the asialoglycoprotein receptor. Asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. ASGR2 is a glycoprotein. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. ASGR2 is the less abundant minor subunit. |
Description | A DNA sequence encoding the human ASGR2 (P07307-1) (Gln80-Ala311) was expressed, with an N-terminal His tag. |
Source | HEK293 |
Predicted N Terminal | His |
AA Sequence | Gln80-Ala311 |
Molecular Weight | The recombinant human ASGR2 comprises 252 a.a. and has a predicted molecular mass of 28.9 kDa. The apparent molecular mass of the protein is approximately 37-42 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
Purity | >95% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |