Name: Recombinant Human ASGR2 Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-0279
Availability: InStock

Recombinant Human ASGR2 Protein (His Tag)

Catalog No.: BLPSN-0279

Product Overview

Tag	His
Host Species	Human
Accession	P07307
Synonym	ASGP-R2, ASGPR2, CLEC4H2, HBXBP, HL-2
Background	ASGR2 is a subunit of the asialoglycoprotein receptor. Asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. ASGR2 is a glycoprotein. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. ASGR2 is the less abundant minor subunit.
Description	A DNA sequence encoding the human ASGR2 (P07307-1) (Gln80-Ala311) was expressed, with an N-terminal His tag.
Source	HEK293
Predicted N Terminal	His
AA Sequence	Gln80-Ala311
Molecular Weight	The recombinant human ASGR2 comprises 252 a.a. and has a predicted molecular mass of 28.9 kDa. The apparent molecular mass of the protein is approximately 37-42 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Purity	>95% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.