Recombinant Human alpha-Synuclein / SNCA Protein
Beta LifeScience
SKU/CAT #: BLPSN-0168
Recombinant Human alpha-Synuclein / SNCA Protein
Beta LifeScience
SKU/CAT #: BLPSN-0168
Catalog No.: BLPSN-0168
Product Overview
| Tag | N/A |
| Host Species | Human |
| Accession | P37840 |
| Synonym | NACP, PARK1, PARK4, PD1 |
| Background | Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). In addition, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease. |
| Description | A DNA sequence encoding the mature form of human SNCA isoform 1 (P37840-1) (Met 1-Ala 140) was expressed and purified. |
| Source | E.coli |
| Predicted N Terminal | Met 1 |
| AA Sequence | Met 1-Ala 140 |
| Molecular Weight | The recombinant human SNCA consisting of 140 a.a. and has a calculated molecular mass of 14.5 kDa. It migrates as an approximately 19 kDa band in SDS-PAGE under reducing conditions. |
| Purity | >97% as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
