Recombinant Human ALDH7A1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0132
Recombinant Human ALDH7A1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0132
Catalog No.: BLPSN-0132
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | P49419 |
| Synonym | ATQ1, EPD, PDE |
| Background | ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Mammalian ALDH7A1 is homologous to plant ALDH7B1 which protects against various forms of stress such as increased salinity, dehydration and treatment with oxidants or pesticides. In mammals, ALDH7A1 is known to play a primary role during lysine catabolism through the NAD+-dependent oxidative conversion of aminoadipate semialdehyde (AASA) to its corresponding carboxylic acid, alpha-aminoadipic acid. Deleterious mutations in human ALDH7A1 are responsible for pyridoxine-dependent and folinic acid-responsive seizures. ALDH7A1 is a novel aldehyde dehydrogenase expressed in multiple subcellular compartments that protects against hyperosmotic stress by generating osmolytes and metabolizing toxic aldehydes. |
| Description | A DNA sequence encoding the human ALDH7A1 isoform 2 (P49419-2) (Ser 2-Gln 511) was expressed, with a His tag at the N-terminus. |
| Source | E.coli |
| Predicted N Terminal | Met |
| AA Sequence | Ser 2-Gln 511 |
| Molecular Weight | The recombinant human ALDH7A1 consisting of 517 a.a. and migrates as an approximately 56 kDa band in SDS-PAGE under reducing conditions as predicted. |
| Purity | >93% as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile 50mM Tris, 500mM NaCl, 20% glycerol, pH 8.0. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
