Recombinant Human AGRP Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0106
Recombinant Human AGRP Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0106
Catalog No.: BLPSN-0106
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | NP_001129.1 |
| Synonym | AGRT, ART, ASIP2 |
| Background | Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally. |
| Description | A DNA sequence encoding the human AgRP (NP_001129.1) (Met 1-Thr 132) was expressed,with a His tag at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Ala 21 |
| AA Sequence | Met 1-Thr 132 |
| Molecular Weight | The recombinant human AgRP consists of 123 a.a. and has a calculated molecular mass of 14 kDa. The apparent molecular mass of rh AgRP is approximately 16-19 kDa in SDS-PAGE under reducing conditions. |
| Purity | >90% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.2. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
