Recombinant Human AGRP Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-0106
Recombinant Human AGRP Protein (His Tag)

Recombinant Human AGRP Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-0106
Catalog No.: BLPSN-0106

Product Overview

Tag His
Host Species Human
Accession NP_001129.1
Synonym AGRT, ART, ASIP2
Background Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.
Description A DNA sequence encoding the human AgRP (NP_001129.1) (Met 1-Thr 132) was expressed,with a His tag at the C-terminus.
Source HEK293
Predicted N Terminal Ala 21
AA Sequence Met 1-Thr 132
Molecular Weight The recombinant human AgRP consists of 123 a.a. and has a calculated molecular mass of 14 kDa. The apparent molecular mass of rh AgRP is approximately 16-19 kDa in SDS-PAGE under reducing conditions.
Purity >90% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.2.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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