Name: Recombinant Human ADAM15 Protein (His Tag)
Brand: Beta LifeScience
SKU: BLPSN-0084
Availability: InStock

Recombinant Human ADAM15 Protein (His Tag)

Catalog No.: BLPSN-0084

Product Overview

Tag	His
Host Species	Human
Accession	NP_997074.1
Synonym	MDC15
Background	ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.
Description	A DNA sequence encoding the human ADAM15 (NP_997074.1) (Met 1-Thr 696) precursor with a C-terminal His tag was expressed.
Source	HEK293
Predicted N Terminal	Asp 207
AA Sequence	Met 1-Thr 696
Molecular Weight	The secreted recombinant human ADAM15 comprises 501 a.a. after proteolytic of the signal peptide and pro peptide and has a predicted molecular mass of 54 kDa. As a result of glycosylation, rh ADAM15 migrates as an approximately 65-70 kDa band in SDS-PAGE under reducing conditions.
Purity	>97% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.