Recombinant Human ACVR2B Protein (His&Fc Tag)

Beta LifeScience SKU/CAT #: BL-0332NP
Recombinant Human ACVR2B Protein (His&Fc Tag)

Recombinant Human ACVR2B Protein (His&Fc Tag)

Beta LifeScience SKU/CAT #: BL-0332NP
Catalog No.: BL-0332NP

Product Overview

Tag His&Fc
Host Species Human
Accession Q13705
Synonym ACVR2B Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; ACVR2B
Background Activin proteins that belong to the transforming growth factor-beta (TGF-beta) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities.
Description Recombinant Human Activin Receptor Type 2B is expressed by our Mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a Fc, His tag at the C-terminus.
Source Human Cells
AA Sequence Ser19-Thr134
Purity >95% as determined by reducing SDS-PAGE.
Endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
Bioactivity Measured by its ability to bind Human Activin A in functional ELISA. The ED50 for this effect is less than 100 ng/ml.
Formulation Recombinant Human ACVR2B Protein was lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution Dissolve the lyophilized protein in distilled water.
Usage For Research Use Only
Storage Human ACVR2B protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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