Recombinant Human ACVR2B Protein (His&Fc Tag)
Beta LifeScience
SKU/CAT #: BL-0332NP
Recombinant Human ACVR2B Protein (His&Fc Tag)
Beta LifeScience
SKU/CAT #: BL-0332NP
Catalog No.: BL-0332NP
Product Overview
| Tag | His&Fc |
| Host Species | Human |
| Accession | Q13705 |
| Synonym | ACVR2B Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; ACVR2B |
| Background | Activin proteins that belong to the transforming growth factor-beta (TGF-beta) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities. |
| Description | Recombinant Human Activin Receptor Type 2B is expressed by our Mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a Fc, His tag at the C-terminus. |
| Source | Human Cells |
| AA Sequence | Ser19-Thr134 |
| Purity | >95% as determined by reducing SDS-PAGE. |
| Endotoxin | <0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Bioactivity | Measured by its ability to bind Human Activin A in functional ELISA. The ED50 for this effect is less than 100 ng/ml. |
| Formulation | Recombinant Human ACVR2B Protein was lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Reconstitution | Dissolve the lyophilized protein in distilled water. |
| Usage | For Research Use Only |
| Storage | Human ACVR2B protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
