Recombinant Cynomolgus Fractalkine / CX3CL1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-2135
Recombinant Cynomolgus Fractalkine / CX3CL1 Protein (His Tag)

Recombinant Cynomolgus Fractalkine / CX3CL1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-2135

Product Overview

Tag His
Host Species Cynomolgus
Background Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.
Description A DNA sequence encoding the cynomolgus CX3CL1 (EHH60415.1) (Met1-Gly100) was expressed with a His tag at the C-terminus. Cynomolgus and Rhesus CX3CL1 sequences are identical.
Source HEK293
Predicted N Terminal Gln 25
AA Sequence Met1-Gly100
Molecular Weight The recombinant cynomolgus CX3CL1 consists of 87 a.a. and predicts a molecular mass of 10.1 kDa.
Purity >(71.4+6.5+20.3)% as determined by SDS-PAGE.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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