Recombinant Cynomolgus EGFR Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1728
Recombinant Cynomolgus EGFR Protein (His Tag)

Recombinant Cynomolgus EGFR Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1728
Catalog No.: BLPSN-1728

Product Overview

Tag His
Host Species Cynomolgus
Accession XP_005549616.1
Background As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-alpha, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Description A DNA sequence encoding the cynomolgus EGFR (XP_005549616.1) (Met1-Ser645) was expressed with a His tag at the C-terminus.
Source HEK293
Predicted N Terminal Leu 25
AA Sequence Met1-Ser645
Molecular Weight The recombinant cynomolgus EGFR consists of 632 a.a. and predicts a molecular mass of 70.1 kDa.
Purity >95% as determined by SDS-PAGE.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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