Recombinant Cynomolgus ART1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0266
Recombinant Cynomolgus ART1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0266
Collections: Other recombinant proteins, Recombinant proteins
Product Overview
| Tag | His |
| Host Species | Cynomolgus |
| Accession | XP_005579037.1 |
| Background | Mono-ADP-ribosyltransferase (ART) 1 belongs to a family of mammalian ectoenzymes that catalyze the transfer of ADP-ribose from NAD+ to a target protein. ART1 is predominantly expressed in skeletal and cardiac muscle. It ADP-ribosylates alpha7-integrin which together with beta1-integrin forms a dimer and binds to laminin, a protein of the extracellular matrix involved in cell adhesion. This posttranslational modification leads to an increased laminin binding affinity. The differentiation-dependent upregulation of ART1 mRNA is induced by the binding of myogenin to an E box and of MEF-2 to an A/T-rich element in the proximal promoter region of the ART1 gene. Colorectal carcinoma is one of the most common cancers world-wide, with high morbidity and mortality rates. Arginine ADP-ribosyltransferase 1(ART1) is an important ecto-ADP-ribose transferase and has been proven to be intimately involved in a number of biological processes. The molecular mechanism for the function of ART1 in colorectal carcinoma and defines a potential therapeutic target for the enhanced treatment of this prominent world-wide disease |
| Description | A DNA sequence encoding the cynomolgus ART1 (XP_005579037.1) (Gln23-Asn294) was expressed with a His tag at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Gln 23 |
| AA Sequence | Gln23-Asn294 |
| Molecular Weight | The recombinant cynomolgus ART1 consists 283 a.a. and predicts a molecular mass of 31.7 kDa. |
| Purity | >95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
