Name: Recombinant Cynomolgus ALK-1 Protein (Fc Tag)
Brand: Beta LifeScience
SKU: BLPSN-0136
Availability: InStock

Recombinant Cynomolgus ALK-1 Protein (Fc Tag)

Catalog No.: BLPSN-0136

Product Overview

Tag	Fc
Host Species	Cynomolgus
Background	Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
Description	A DNA sequence encoding the cynomolgus ACVRL1 (Met1-Gln118) was expressed with the Fc region of human IgG1 at the C-terminus.
Source	HEK293
Predicted N Terminal	Asp 22
AA Sequence	Met1-Gln118
Molecular Weight	The recombinant cynomolgus ACVRL1 is a disulfide-linked homodimer. The reduced monomer comprises 338 a.a. and has a calculated molecular mass of 37.8 KDa.The apparent molecular mass of the protein is approximately 53 KDa respectively in SDS-PAGE.
Purity	>90% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Measured by its ability to inhibit BMP9-induced alkaline phosphatase production by MC3T3-E1 cells.The ED50 for this effect is typically 1-5 ng/ml.
Formulation	Lyophilized from sterile PBS, pH 7.4.
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.