Native B. pertussis Bordetella pertussis toxin/ptxD Protein
Beta LifeScience
SKU/CAT #: BLA-11728P
Native B. pertussis Bordetella pertussis toxin/ptxD Protein
Beta LifeScience
SKU/CAT #: BLA-11728P
Collections: Other recombinant proteins, Recombinant proteins
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Host Species | Bordetella pertussis |
Accession | P04977 |
Synonym | IAP S1 Islet-activating protein S1 NAD-dependent ADP-ribosyltransferase |
Description | Native B. pertussis Bordetella pertussis toxin/ptxD Protein is native.. It is a Full length protein |
Source | Native |
Molecular Weight | 30 kDa |
Purity | >95% SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Lyophilised |
Stability | The recombinant protein samples are stable for up to 12 months at -80°C |
Reconstitution | See related COA |
Unit Definition | For Research Use Only |
Storage Buffer | Shipped at 4°C. Store at +4°C. Avoid freeze / thaw cycle. |
Target Details
Target Function | S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors. |
Subcellular Location | Secreted. Note=The individual chains are secreted by a sec-dependent mechanism into the periplasm. Then, S1 associates with the outer membrane before it joins with the B subunit to form the secretion-competent holotoxin. The type IV secretion system ptl mediates secretion of assembled toxin through the outer membrane. |
Protein Families | Bacterial exotoxin subunit A family |
Database References | KEGG: bpe:BP3783 STRING: 257313.BP3783 |
Gene Functions References
- It has been proposed that it is the systemic activity of pertussis toxin and not pulmonary pathology that promotes mortality in critical pertussis. PMID: 28784932