IL23 P19 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2839
IL23 P19 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2839
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | IL-23 P19 Protein |
Accession | Q9NPF7 |
Background | IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35[1]. IL-23 is a heterodimeric cytokine, comprised a unique p19 subunit and p4 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rbeta1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway [11,12]. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis[13], primary biliary cirrhosis[14], and inflammatory bowel disease[15].Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy |
Description | A DNA sequence encoding the human IL23A (Q9NPF7) (Met1-Pro189) was fused with a His tag at the C-terminus, constructed the plasmid 1; A DNA sequence encoding the mouse IL12B (P43432) (Met1-Ser335) was expressed with a His tag at the C-terminus, constructed the plasmid 2. The two plasmids were co-expressed and the human IL23A & the mouse IL12B heterodimer was purified. |
Source | HEK293 |
Predicted N Terminal | Arg 20 & Met 23 |
AA Sequence | Met1-Ser335 |
Molecular Weight | The recombinant human IL23A & the mouse IL12B comprises 505(181+324) a.a. and has a calculated molecular mass of 57.3 (20.1+37.2) KDa. |
Purity | >(37.6+41.4+20.5)% as determined by SDS-PAGE. |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4.. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |