IL17 Protein, Marmoset
Beta LifeScience
SKU/CAT #: BLPSN-2707
IL17 Protein, Marmoset
Beta LifeScience
SKU/CAT #: BLPSN-2707
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | N/A |
Host Species | Marmoset |
Accession | ABQ09496.1 |
Background | IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy |
Description | A DNA sequence encoding the Marmoset IL17A (ABQ09496.1) (Ile20-Ala155) was expressed and purified with an initial Met. |
Source | E.coli |
Predicted N Terminal | Met |
AA Sequence | Ile20-Ala155 |
Molecular Weight | The recombinant Marmoset IL17A consists of 135 a.a. and has a calculated molecular mass of 15.4 kDa. It migrates as an 17 kDa band in SDS-PAGE under reducing conditions. |
Purity | >85% as determined by SDS-PAGE |
Endotoxin | Please contact us for more information. |
Bioactivity | 1. Measured by its binding ability in a functional ELISA. Immobilized Marmoset IL17A at 10 ug/mL (100 ul/well) can bind human IL17Ra, The EC50 of human IL17Ra is 8.5-20.0 ng/mL.2. Measured by its ability to induce IL-6 secretion by HFF human foreskin fibroblast cells.The ED50 for this effect is typically 2.95-11.8 ng/mL. |
Formulation | Lyophilized from sterile PBS, pH 7.4.. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |