{"title":"Buy Cytokines, Chemokines, and Growth Factors for Research Online","description":"\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSome factors, like cytokines, chemokines, and growth factors, have special roles in cell signalling, immune regulation, and tissue regeneration. These proteins are necessary for biomedical research, drug discovery, and therapeutic development, making them a great choice for scientists and researchers. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAt BetaLifeSci, we offer a high-quality bioactive protein for research. Our products go through strict testing for purity, safety, and reliability so that you can get results every time. Researchers can trust our proteins to deliver perfect and repeatable results in every application.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eExplore our huge range of cytokines, chemokines, and growth factors made for immunology, oncology, stem cell research, and regenerative medicine. Whether you need large orders or special formulations, we provide reliable solutions to support groundbreaking discoveries. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eWhat Are Cytokines, Chemokines, and Growth Factors?\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCytokines, chemokines, and growth factors are the\u003c\/span\u003e\u003cspan\u003e key regulator proteins\u003c\/span\u003e\u003cspan\u003e that control cell signaling, immune responses, and tissue regeneration. These molecules allow cells to communicate, supporting immune functions, reducing inflammation, and repairing tissues. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWith the help of biomedical research, cytokines and chemokines help scientists understand immune system functions and disease mechanisms. Still, the growth factors are important for stem cell studies and regenerative medicine. Their application extends to drug development, cancer research, and diagnostic assays, making them essential for both lab work and medical treatments.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eWhy Choose Beta LifeScience for Cytokines and Growth Factors?\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBeta LifeScience offers high-quality, research-grade cytokines, chemokines, and growth factors with proven effectiveness and reliability. Our products help advance research in immunology, oncology, and regenerative medicine.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch4 dir=\"ltr\"\u003e\u003cspan\u003eKey Benefits:\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eValidated Bioactivity\u003c\/span\u003e\u003cspan\u003e: Each protein undergoes rigorous testing to ensure optimal performance.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eCustomizable Options\u003c\/span\u003e\u003cspan\u003e: Tailored formulations available for specific research needs.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eFast Global Shipping\u003c\/span\u003e\u003cspan\u003e: Reliable and quick delivery to laboratories worldwide.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eStrict Quality Control\u003c\/span\u003e\u003cspan\u003e: Produced in certified facilities for consistent purity.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eExpert Support\u003c\/span\u003e\u003cspan\u003e: Dedicated team to assist with product selection and application guidance.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eCytokines for Immunology and Inflammation Studies\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eOur collection includes \u003c\/span\u003e\u003cspan\u003ekey cytokines\u003c\/span\u003e\u003cspan\u003e such as IL-6 and IL-10, which play a vital role in immune system regulation and inflammation research. These cytokines are essential for:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eAutoimmune disease modeling\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eInflammatory response studies\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eVaccine development\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003ca href=\"https:\/\/www.betalifesci.com\/collections\/cytokines-chemokines-and-growth-factors\" target=\"_blank\" rel=\"noopener\"\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/lh7-rt.googleusercontent.com\/docsz\/AD_4nXcxSxCt2Td14Q54hvdmNZxowCh4GE9ZR0fnYu5hnwlIENEHGwd5LAs8tPkkXSWVqFWTb3W2cMneBTKQCrFjX3yj1LvesSXOGh2yB4kyBxEBhIAiMG5XMRYZsv8PpSMOKolPYa-1PA?key=F-_SCHBFljdE8G7PW3N0esvS\" width=\"624\" height=\"100\"\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eChemokines for Cell Migration and Signaling Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eChemokines, like \u003c\/span\u003e\u003cspan\u003eCXCL12 and CCL5\u003c\/span\u003e\u003cspan\u003e, are crucial for studying cell migration, immune responses, and cancer metastasis. Our chemokines are:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eExpressed in \u003c\/span\u003e\u003cspan\u003emammalian and bacterial systems\u003c\/span\u003e\u003cspan\u003e for high purity.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eIdeal for \u003c\/span\u003e\u003cspan\u003ecancer research and immune cell trafficking studies\u003c\/span\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eAvailable in \u003c\/span\u003e\u003cspan\u003erecombinant and native forms\u003c\/span\u003e\u003cspan\u003e for diverse applications.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003ca href=\"https:\/\/www.betalifesci.com\/collections\/chemokines-and-receptors\" target=\"_blank\" rel=\"noopener\"\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/lh7-rt.googleusercontent.com\/docsz\/AD_4nXfzE9eZwa14KhbiXsor213rm3YBo4dqwzO5dkkzpTac4Z0FhXJhnYLlSxiMAROjBoQZTd7Vd_AyyidR8Y6KIorgFYFPOFlfszFkss3wosVCywl79e7k3u6COS1PUmNPlgviabW5?key=F-_SCHBFljdE8G7PW3N0esvS\" width=\"624\" height=\"100\"\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eGrowth Factors for Cell Culture and Tissue Engineering\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eGrowth factors such as \u003c\/span\u003e\u003cspan\u003eVEGF, EGF, and FGF\u003c\/span\u003e\u003cspan\u003e are essential for cell proliferation, differentiation, and tissue regeneration. Our growth factors support the following:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eStem cell and regenerative medicine research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eCancer therapy studies\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eWound healing and tissue engineering applications\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003ca href=\"https:\/\/www.betalifesci.com\/collections\/growth-factors-and-receptors\" target=\"_blank\" rel=\"noopener\"\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/lh7-rt.googleusercontent.com\/docsz\/AD_4nXcL9g95QKdceV8FA-ejaSCQeu2nLWr4zpBg2z0FwdQv4w_abbkqVZ-ZzV6IUDkPvU7P4h7ZSTTYV4KM5FWwiNLTRjhxQva97qMUKQgIJGi_CyPvcSYIcXjwBIuxS64u6VfOIvgL?key=F-_SCHBFljdE8G7PW3N0esvS\" width=\"624\" height=\"100\"\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eApplications of Cytokines, Chemokines, and Growth Factors in Research\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCytokines, chemokines, and growth factors play a crucial role in \u003c\/span\u003e\u003cspan\u003ecell signaling, immune modulation, and tissue regeneration\u003c\/span\u003e\u003cspan\u003e, making them essential tools in \u003c\/span\u003e\u003cspan\u003ebiomedical research and therapeutic development\u003c\/span\u003e\u003cspan\u003e. Their precise application in various fields enhances experimental outcomes and translational research.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eImmunology \u0026amp; Inflammation Studies\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eCytokines like IL-6, IL-10, and TNF-α are critical for studying autoimmune diseases, inflammatory responses, and immune cell differentiation.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eChemokines regulate immune cell migration, aiding in research on infection response and chronic inflammation.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 dir=\"ltr\"\u003e\u003cspan\u003eCancer Research \u0026amp; Targeted Therapies\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eGrowth factors such as VEGF and FGF drive tumor angiogenesis studies.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eChemokines like CXCL12 play a role in cancer metastasis and tumor microenvironment research.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 dir=\"ltr\"\u003e\u003cspan\u003eStem Cell \u0026amp; Regenerative Medicine\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eGrowth factors like EGF and BMPs promote cell differentiation and tissue repair.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eCytokines help regulate immune tolerance in transplantation studies.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 dir=\"ltr\"\u003e\u003cspan\u003eNeuroscience \u0026amp; Neuroinflammation\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eCytokines like IL-1β and IFN-γ contribute to neurodegenerative disease research.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eGrowth factors such as BDNF and NGF support nerve regeneration and brain function studies.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eQuality Control \u0026amp; Manufacturing Standards\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAt Beta LifeScience, we prioritize \u003c\/span\u003e\u003cspan\u003eproduct quality and reliability\u003c\/span\u003e\u003cspan\u003e, ensuring that researchers receive \u003c\/span\u003e\u003cspan\u003ehigh-purity, bioactive proteins\u003c\/span\u003e\u003cspan\u003e that meet rigorous industry standards.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch4 dir=\"ltr\"\u003e\u003cspan\u003eEndotoxin-Free and Sterile Formulations\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eProducts are rigorously tested for endotoxin levels, ensuring safety for cell culture and in vivo applications.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eSterile manufacturing processes minimize contamination risks.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4 dir=\"ltr\"\u003e\u003cspan\u003eStringent Purity and Bioactivity Testing\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eEach batch undergoes HPLC, SDS-PAGE, and functional assays to verify purity, molecular weight, and biological activity.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eCertificates of analysis (CoA) and validation data are provided for research transparency and reproducibility.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eFAQs\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eWhat are cytokines, chemokines, and growth factors used for in research?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCytokines and other molecules have a great role in cell signaling, immune response regulation, and tissue regeneration. Specialists use them in immunology, cancer research, stem cell studies, and drug development. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eHow do I choose the right cytokine or growth factor for my experiment?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIf you want to select the format, it depends on the research objective and target cell type. We offer detailed product descriptions and expert support to help you find the best fit for your study. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eAre Beta LifeScience cytokines and growth factors tested for purity?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eOfcourse, every product undergoes strict quality control, adding SDS PAGE, HPLC, and bioactivity assays, guaranteeing high purity and reproducibility. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eDo your products contain endotoxins?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSome products like recombinant endotoxin are not found, which makes them a top choice for vivo studies and cell culture experiments. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eHow should I store cytokines and growth factors?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eStorage conditions are different for every product, but most need to be kept at -20°C or -80°C. Check the product datasheet for the exact instructions. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eDo you offer bulk or custom production services?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eOfcourse, we offer custom formulations, bulk orders, and protein modifications that fit your research requirements. Contact our team for more details. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eWhy Buy from BetaLifeSci?\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBuy cytokines, chemokines, and growth factors for research online with confidence from BetaLifeSci. We offer high-purity recombinant proteins validated through rigorous quality control. Our products are endotoxin-free, bioactive, and optimized for immunology, cancer research, and regenerative medicine. With fast global shipping, bulk order options, and expert support, we ensure reliable results for your experiments.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","products":[{"product_id":"recombinant-human-fgfr3-protein-ecd-his-tag-blpsn-2074","title":"Recombinant Human FGFR3 Protein (ECD, His Tag)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHis\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNP_000133.1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFGFR3, ACH, CD333, CEK2, HSFGFR3EX, JTK4, fibroblast growth factor receptor 3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene.[5] FGFR3 has also been designated as CD333 (cluster of differentiation 333). The gene, which is located on chromosome 4, location p16.3, is expressed in tissues such as the cartilage, brain, intestine, and kidneys.The FGFR3 gene produces various forms of the FGFR3 protein; the location varies depending on the isoform of the FGFR3 protein. Since the different forms are found within different tissues the protein is responsible for multiple growth factor interactions.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eA DNA sequence encoding the human FGFR3 (Met1-Gly375) was expressed with a His tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePredicted N Terminal\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGlu 23\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eMet1-Gly375\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant human FGFR3 consists 364 amino acids and predicts a molecular mass of 39.6 kDa.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026gt;95% as determined by SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg protein as determined by the LAL method.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003ePlease contact us for detailed information\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human FGFR3 Protein (ECD, His Tag) was lyophilized from sterile PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human FGFR3 protein is stable up to 1 year at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eStore the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42875190247649,"sku":"BLPSN-2074","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-c8-protein-his-tag-bl-1563np","title":"Recombinant Human C8 gamma Protein (N-6His)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Complement Component C8 Gamma Chain is produced by our E.coli expression system and the target gene encoding Gln21-Arg202 is expressed with a 6His tag at the N-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003ca title=\"AAI13627.1\" target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/protein\/AAI13627.1\"\u003eAAI13627.1\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eComplement component C8 gamma chain; C8G\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eComplement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Patients lacking C8 are susceptible to certain bacterial infections.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e22.6 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e22 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSupplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eStore at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening.  Please minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped on dry ice\/polar packs. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915066736865,"sku":"BL-1563NP","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-mouse-ngf-ngfb-protein-bl-1697np","title":"Recombinant Mouse Beta-NGF Protein (110AA)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Mouse Beta-Nerve Growth Factor is produced by our E.coli expression system and the target gene encoding Met130-Arg239 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP01139\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBeta-Nerve Growth Factor; Beta-NGF; NGF; NGFB;β-NGF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an important role in neuroprotection and repair. β-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. It is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e12.4 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e13 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, pH 8.0.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBiologically active. Please contact us to obtain bioactivity data.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg\/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and\/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted. Endosome lumen.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNGF-beta family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            mmu:18049           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            10090.ENSMUSP00000102538           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        29875237            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            Mechanoinsensitive ''silent'' nociceptors are characterized by the expression of the nicotinic acetylcholine receptor subunit alpha-3 (CHRNA3); the mechanically gated ion channel PIEZO2 mediates NGF-induced mechanosensitivity in these neurons.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29241539            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            antibodies raised against NGF, TrkA, and p75 (also known as CD271) were used to explore the expression of these antigens in the non-decalcified young mouse femur.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29166838            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            An inducible mouse model that can dissect the contribution of autocrine direct action of cleavage-resistant proNGF on systemic microvascular abnormalities in both retina and kidney, major targets for microvascular complication.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29253516            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            both in vivo mechanical loading and in vitro mechanical stretch were shown to induce the profound up-regulation of NGF in osteoblasts within 1 h of loading.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28416686            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Nerve growth factor negatively regulates bone marrow granulopoiesis during small intestinal inflammation            \u003ca rel=\"nofollow\"\u003e             PMID:                        26683342            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study may represent a common mechanism for selective follicular activation induced by a localized increase in NGF in interstitial cells and mediated via the mTOR signaling pathway.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28542147            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            nerve growth factor (NGF) signaling through neurotrophic tyrosine kinase receptor type 1 (TrkA) directs innervation of the developing mouse femur to promote vascularization and osteoprogenitor lineage progression.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27568565            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Mechanical stress-induced upregulation of NGF in colon SMC underlies the visceral hypersensitivity in bowel obstruction through increased gene expression and activity of tetrodotoxin-resistant Na channels in sensory neurons.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28079757            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            results suggest that perivascular nerves innervate neovessels as neovasculatures mature and that NGF accelerates the innervation of perivascular nerves in neovessels.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27493098            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These findings reveal a non-neuronal role for neurotrophins and identify a new regulatory pathway in insulin secretion that can be targeted to ameliorate beta cell dysfunction.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27825441            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF signalling directly controls basal APP phosphorylation, subcellular localization and BACE cleavage.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27076121            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF facilitates OVA with lowLPS-induced maturation of mouse BMDCs through LPS-up-regulated p75 NTR via activation of NF-kappaB pathways, providing another mechanism for the involvement of NGF in the Th2 response            \u003ca rel=\"nofollow\"\u003e             PMID:                        27437725            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF-OE mice exhibit age-dependent increases in Substance P and CGRP in the urothelium and hyperinnervation of the bladder.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27342083            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TNF-alpha upregulated Nerve Growth Factor [NGF] expression in synovial fibroblasts and macrophages and IL-1beta upregulated NGF expression in synovial fibroblasts. IL-1beta and TNF-alpha may regulate NGF signaling in Osteoarthritic joints and be suitable therapeutic targets for treating Osteoarthritis pain            \u003ca rel=\"nofollow\"\u003e             PMID:                        27635406            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            functional PAP(thorn) neurons are essential for the analgesic effect, which is mediated by NGF-trkA signaling.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27306411            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF negatively regulates growth cone retrograde actin flow on laminin.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26631553            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In E-Reeler retinas, NGF was significantly increased in retinal ganglion cells and glial cells. E-Reeler retinal bipolar cells and RGCs overexpress NGF and p75(NTR) as a protective endogenous response to Reelin deprivation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26066836            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The NGF-induced up-regulation of TRPV1 via the increased synthesis and release of endogenous CGRP leads to improved cardiac performance in I\/R-injured diabetic heart.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25650182            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF effects on parasympathetic nerves may regulate airway smooth muscle.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25647301            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Ginger extract has a synaptogenic effect via NGF-induced ERK\/CREB activation, resulting in memory enhancement.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25049196            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Proinflammatory cytokines in osteoarthritis (OA) joints and the increased mechanical loading of cartilage may mediate OA pain via the stimulation of NGF expression and release by chondrocytes            \u003ca rel=\"nofollow\"\u003e             PMID:                        24438745            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Despite being highly conserved, NGF and proNGF of mouse and human origins show distinct properties.Special care must be taken in performing experiments with cross-species systems.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25496838            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF exhibits anti-oxidative and hepatoprotective effects and is suggested to be therapeutically applicable in treating cholestatic liver diseases.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25397406            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results indicate that analgesic effect of CB1 activation may in part be due to inhibition of NGF-induced sensitization of TRPV1 and also that the effect of CB1 activation is at least partly mediated by attenuation of NGF-induced increased PI3 signaling            \u003ca rel=\"nofollow\"\u003e             PMID:                        25088915            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF induces removal of active caspase-3 in a lysosome-dependent manner.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24787014            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results indicate that NGF exerts antileishmanial effect by stimulating hydrogen peroxide production in macrophages.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24937592            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            iron accumulation induces NGF expression in hepatocytes, which in turn leads to LSEC defenestration via TrkA            \u003ca rel=\"nofollow\"\u003e             PMID:                        25460199            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These findings suggest that overexpression of NGF in the ovary may suffice to cause both reproductive and metabolic alterations characteristic of polycystic ovary-like syndrome (PCOS) and support the hypothesis that sympathetic hyperactivity may contribute to the development and\/or progression of PCOS.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25211588            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The increased NGF concentrations abolish Sema3A-induced inhibitory effect on axon outgrowth, while they have no effect on Sema3A-induced collapse rate.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24338202            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data suggest that proNGF may appeal a new pathway or possible mechanism underlying microglial toxicity in the neuroinflammation and a potential target for therapeutic manipulation of the neurodegenerative diseases.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24040063            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            beta-NGF gene transfection promotes the differentiation of bone marrow stromal stem cells into neurons through regulation of AKT and MAPKs signaling pathways.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23934089            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            mechanical stimulation may attenuate NGFbeta signaling through Rac1            \u003ca rel=\"nofollow\"\u003e             PMID:                        23989259            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Independent of genotype, folate deficiency affects NGF levels in the frontal cortex, amygdala and hippocampus.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23623989            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            calcineurin\/NFAT pathway mediates the upregulation of PAI-1 by NGF            \u003ca rel=\"nofollow\"\u003e             PMID:                        23825664            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            ProNGF\\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23538417            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            elevated levels of NGF in target tissues stimulate sympathetic and sensory axonal sprouting            \u003ca rel=\"nofollow\"\u003e             PMID:                        23322532            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            PIP5Kalpha acts as a negative regulator of nerve growth factor-induced neurite outgrowth by inhibiting PI3K\/Akt signaling pathway in PC12 cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23538529            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data suggest that diet factors (i.e., olive pomace polyphenols) up-regulate NGF\/TrkA (proto-oncogene trk) and BDNF\/TrkB (brain derived neurotrophic factor\/receptor) in hippocampus\/olfactory bulb and down-regulate NGF\/BDNF in frontal cortex\/striatum.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23466052            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data suggest that expression of NGF is down-regulated in wounded skin (epidermis) in diabetes; among the growth factors investigated, only expression of NGF was down-regulated in healing skin wounds of diabetic mice as compared to nondiabetic mice.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23426701            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            proNGF selectively promotes the growth of neurites from a subset of NGF-responsive neurons by a p75(NTR)-dependent mechanism during postnatal development when the axons of these neurons are ramifying within their targets in vivo            \u003ca rel=\"nofollow\"\u003e             PMID:                        23633509            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Overexpression of mouse NGF in urothelium \u0026amp; detrusor affected transcription of PAC1, VPAC1, VPAC2, PAPCAP, VIP \u0026amp; other peptides normally \u0026amp; in cyclophosphamide-induced cystitis. The changes were tissue- and disease-duration dependent.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22700375            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The HTM1 heterodimer of 2 NGF muteins binds p75 and TrkA on opposite sides of the heterodimer, but not 2 TrkA receptors, supporting the ligand passing of NGF from p75 to TrkA via a transient heteroreceptor complex of p75-NGF-TrkA.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22903500            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our results suggest that BDNF-TrkB but not NGF-TrkA signaling is involved in the brain repair after ICH, and early proper treadmill exercise might promote this repair process.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22999926            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Expression of NGF in hippocampus, cortex, and adrenal gland of wild type animal tended to decrease following spaceflight.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22808101            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study demonstrated that both TrkA and NGF support the survival of only a subset of basal forebrain cholinergic neuron during brain development.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23100411            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Letter: NGF-p75 and neuropsin\/KLK8 pathways may cooperate in regulation of epidermal homeostasis in inflamed skin.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22520925            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            that NGF derived from bronchial and alveolar epithelium plays an important role in airway hyperresponsiveness after chronic exposure to mite antigen            \u003ca rel=\"nofollow\"\u003e             PMID:                        22168511            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Therapeutic potential of NGF for the prevention of cardiomyopathy in diabetic subjects.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22187379            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF exerts profibrotic activities in the airways by inducing type III collagen production in fibroblasts            \u003ca rel=\"nofollow\"\u003e             PMID:                        21816457            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915102257377,"sku":"BL-1697NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLVqAb-UOAADAjuU8JvM359_c447bbe5-a0dd-4511-8908-084faf3df6c5.jpg?v=1685853334"},{"product_id":"recombinant-human-ngf-ngfb-protein-bl-1701np","title":"Recombinant Human Beta-NGF Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Beta-Nerve Growth Factor is produced by our E.coli expression system and the target gene encoding Ser122-Ala241 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP01138\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBeta-Nerve Growth Factor; Beta-NGF; NGF; NGFB;β-NGF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eHuman β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits α, β, and γ; it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its receptor β-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90% sequence similarity with mouse protein and shows cross-species reactivity.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e13.4 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e14 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.001 ng\/µg (0.01 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg\/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and\/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted. Endosome lumen.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNGF-beta family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            7808           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            162030           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:4803           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000358525           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        29527653            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            Single nucleotide polymorphisms in NGF gene (rs6330) and NGFR gene (rs2072446 and rs734194) are associated with ischemic stroke. The NGF rs6330*T and NGFR rs2072446*T minor alleles might be nominated as a risk factor for developing ischemic stroke and NGFR rs734194*G minor allele as a protective against this disease at least in Armenian population            \u003ca rel=\"nofollow\"\u003e             PMID:                        29499660            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Neurotrophic factors and hippocampal activity in PTSD            \u003ca rel=\"nofollow\"\u003e             PMID:                        29799860            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            SNRPA may contribute to GC progression via NGF and could be a prognostic biomarker for GC.            \u003ca rel=\"nofollow\"\u003e             PMID:                        30039889            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results show that NGF signalling is strongly linked to pathological and regenerative processes in human teeth.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28465581            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results suggest an interaction between NGF, GDNF and MMP-9 during the transition to malignancy in prostate cancer (PC). Also this interaction may involve in regulating PC cell differentiation, tumor invasion, progression, and the agressiveness of PC.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28237042            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the anti-tumor activity of oleuropein against hepatocellular carcinoma could be attributed to influencing the pro-NGF\/NGF balance via affecting MMP-7 activity without affecting the gene expression of NGF            \u003ca rel=\"nofollow\"\u003e             PMID:                        29476769            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            co-expression patterns of NGF and heme oxygenase-1 might be used as prognostic indicators for gastric carcinoma patients            \u003ca rel=\"nofollow\"\u003e             PMID:                        28679437            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This review will briefly address the peripheral and central sensitization mechanisms of airway neurons and will then focus on NGF signaling and its role in cough hypersensitivity.[review]            \u003ca rel=\"nofollow\"\u003e             PMID:                        28494216            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            First-trimester plasma nerve growth factor is lower in patients who subsequently develop preeclampsia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27513943            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study show evidence of variation in plasmatic beta-NGF expression during the progression of dementia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27802234            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF is functionally linked to beta-catenin, promoting the migration of human ovarian cancer cells via the WNT\/beta-catenin pathway.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27835587            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Varicella zoster virus DNA replication is regulated in part by an NGF pathway that is PI3-kinase-independent.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27683235            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Many studies indicate that the only presence of NGF is unable to generate cell carcinogenesis, both in normal neuronal and non-neuronal cells\/tissues. However, it cannot be excluded the possibility that the co-expression of NGF and pro-carcinogenic molecules might open to different consequence. [review]            \u003ca rel=\"nofollow\"\u003e             PMID:                        27439311            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the effect and underlying mechanisms of NGF\/BDNF on the production of NPW in PC12 cells and hypothalamus, is reported.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28249734            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These data support a role for islet NGF in fine-tuning insulin secretion.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27424144            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results of this study indicated that dysmenorrhea pain severity is partly genetically determined by the chromosome 1p13.2, near the nerve growth factor locu.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27454463            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Findings suggest that IL-1beta and TNF-alpha regulate Nerve Growth Factor expression and production in synovial macrophages and fibroblasts in osteoarthritic joints.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28677145            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results advance our knowledge of the conformational properties of proNGF and NGF and help provide a rationale for the diverse biological effects of NGF and proNGF at the molecular level.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28798232            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results of this study suggest that proNGF protein levels may augment the diagnostic accuracy of currently used CSF biomarker panels.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26825093            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Neuroimmune-endocrine events may lead to overactivity of sympathetic nervous system that triggers cascade of pathologic conditions in ovary in polycystic ovary syndrome (PCOS). Data suggest women with PCOS exhibit reduction of CRH and NGF; reduction of CRH\/NGF may be under influence of sympathetic nervous system and may reflect deficit of neuronal stress-adaptation in PCOS patients. (CRH = corticotropin releasing hormone)            \u003ca rel=\"nofollow\"\u003e             PMID:                        27908212            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The rare nerve growth factor-beta (NGFB) mutation R221W causes a selective loss of thinly myelinated fibers and especially unmyelinated C-fibers. Carriers of this mutation show altered pain sensation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27146986            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF expression was positively correlated with disease severity and visceral hypersensitivity in irritable bowel syndrome patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27862119            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            a stage-related modulation of beta-NGF and its receptors in the inflammatory process of OA            \u003ca rel=\"nofollow\"\u003e             PMID:                        28253191            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BDNF and NGF serum levels are reduced in the early and moderate glaucoma stages, suggesting the possibility that both factors could be further investigated as potential circulating biomarkers for the early detection of glaucoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28068360            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            overexpression of ARMS blocked NGF-mediated secretion, without affecting basal secretion, a decrease in ARMS resulted in potentiation. Similar effects were observed with synembryn-B, a protein that interacts directly with ARMS. Downstream of ARMS and synembryn-B are Galphaq and Trio proteins, which modulate the activity of Rac1 in response to NGF            \u003ca rel=\"nofollow\"\u003e             PMID:                        26966186            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data show that the standardized nerve growth factor (NGF) concentration was negatively correlated with continuous pain, neuropathic pain and total score, and the standardized S100 proteins S100A8\/A9 concentration was positively correlated with present pain intensity and continuous pain.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27936243            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results indicate that NGF inhibited CRT translocation induced by mitoxantrone. NGF effect on CRT translocation could have consequences in immunotherapy, potentially lessening the effectiveness of this type of treatment.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28260038            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF stimulates generation of neurons, but not neuronal progenitors from embryonic stem cells and affects the proportion of specific types of neurons in cultures of differentiating embryonic stem cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28364186            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF attenuates these responses-both in vivo and in vitro. Therefore, NGF therapy may represent a novel approach for the management of diabetic keratopathy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27978558            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF signaling pathway provides a potential target for developing molecularly targeted therapies            \u003ca rel=\"nofollow\"\u003e             PMID:                        27792755            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these data suggest a positive feedback loop through which NGF-mediated upregulation of p75(NTR) can contribute to the chemo-resistance of Triple negative breast cancer cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27577679            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Based on these current developments, the present review provides not only a broad overview of the biological effects of NGF-TrkA-p75NTR on cancer cells and their microenvironment, but also explains why NGF and its receptors are going to evoke major interest as promising therapeutic anti-cancer targets in the coming decade.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27264679            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF\/CD133 might be an effective and potent therapeutic target for pancreatic cancer metastasis, particularly in perineural invasion            \u003ca rel=\"nofollow\"\u003e             PMID:                        27654574            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The analysis of covariance (ANCOVA) indicated that the mean serum GDNF and NTF3 levels of ADHD patients were significantly higher than that of controls. However, serum BDNF and NGF levels did not show any significant differences between groups.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27561780            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            All patients had serum neurotrophin (NT-3, BDNF, NGF) concentrations determined.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27367919            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Serum NGF does not differentiate between recurrent acute pancreatitis and chronic pancreatitis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27020638            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        26962689            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Major depression patients had similar serum NGF to controls.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27008247            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            data demonstrate the involvement and modulation of nerve growth factor and its receptors in chronic obstructive pulmonary disease and in its staging            \u003ca rel=\"nofollow\"\u003e             PMID:                        26408608            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The present study showed that IL-17, in addition to stimulating an inflammatory response, negatively regulates the action of NGF and NGF R in the polar forms of the leprosy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26616164            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Locally increased estrogen levels and inflammation may cause increased NGF production in the uterus of patients with adenomyosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25519715            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The present study is the first to thoroughly assess the enhancement of neural differentiation of bone marrow mesenchymal stem cells following transfection with bFGF and NGF.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26572749            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data suggest MMP7 (matrix metalloproteinase 7) in follicular fluid cleaves proNGF (pro-nerve growth factor) in ovarian follicle; both MMP7 and proNGF appear to be products of granulosa cells; processing of proNGF to NGF appears to regulate apoptosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26457789            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF promotes renal fibrosis via TGF-beta1-signaling activation, suggesting that in kidney diseases high NGF serum levels could contribute to worsen renal fibrosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26066770            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study suggests that the circadian rhythm in the esophagus may be important for the mediation of and\/or the response to erosive damage in GERD patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26337663            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Intratumoral nerve growth factor expression is not associated with perineural invasion in patients with resected extrahepatic cholangiocarcinoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26547754            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF has a role in modulating trkANGFR\/p75NTR in alphaSMA-expressing conjunctival fibroblasts from human ocular cicatricial pemphigoid            \u003ca rel=\"nofollow\"\u003e             PMID:                        26569118            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF-induced tyrosine kinase independent TrkA signaling through CD44 is sufficient to maintain tumor aggressiveness in breast cancer            \u003ca rel=\"nofollow\"\u003e             PMID:                        25840418            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Urinary NGF, but not BDNF, levels decreased significantly after hyaluronic acid therapy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24614892            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915099439329,"sku":"BL-1701NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLSGAWtdsAACfla_PP38662_6a4bfe57-137c-4180-b700-1e7b0e34f79f.jpg?v=1685853214"},{"product_id":"recombinant-human-ngf-ngfb-protein-bl-1705np","title":"Recombinant Human Beta-NGF Protein (Mammalian)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Beta-Nerve Growth Factor is produced by our Mammalian expression system and the target gene encoding Ser122-Arg239 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP01138\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBeta-Nerve Growth Factor; Beta-NGF; NGF; NGFB;β-NGF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eHuman β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits α, β, and γ; it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its receptor β-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90% sequence similarity with mouse protein and shows cross-species reactivity.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e13.3 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e14 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.0.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by SEC-HPLC. (Regularly tested)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBiologically active. Please contact us to obtain bioactivity data.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg\/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and\/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted. Endosome lumen.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNGF-beta family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            7808           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            162030           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:4803           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000358525           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        29527653            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            Single nucleotide polymorphisms in NGF gene (rs6330) and NGFR gene (rs2072446 and rs734194) are associated with ischemic stroke. The NGF rs6330*T and NGFR rs2072446*T minor alleles might be nominated as a risk factor for developing ischemic stroke and NGFR rs734194*G minor allele as a protective against this disease at least in Armenian population            \u003ca rel=\"nofollow\"\u003e             PMID:                        29499660            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Neurotrophic factors and hippocampal activity in PTSD            \u003ca rel=\"nofollow\"\u003e             PMID:                        29799860            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            SNRPA may contribute to GC progression via NGF and could be a prognostic biomarker for GC.            \u003ca rel=\"nofollow\"\u003e             PMID:                        30039889            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results show that NGF signalling is strongly linked to pathological and regenerative processes in human teeth.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28465581            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results suggest an interaction between NGF, GDNF and MMP-9 during the transition to malignancy in prostate cancer (PC). Also this interaction may involve in regulating PC cell differentiation, tumor invasion, progression, and the agressiveness of PC.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28237042            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the anti-tumor activity of oleuropein against hepatocellular carcinoma could be attributed to influencing the pro-NGF\/NGF balance via affecting MMP-7 activity without affecting the gene expression of NGF            \u003ca rel=\"nofollow\"\u003e             PMID:                        29476769            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            co-expression patterns of NGF and heme oxygenase-1 might be used as prognostic indicators for gastric carcinoma patients            \u003ca rel=\"nofollow\"\u003e             PMID:                        28679437            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This review will briefly address the peripheral and central sensitization mechanisms of airway neurons and will then focus on NGF signaling and its role in cough hypersensitivity.[review]            \u003ca rel=\"nofollow\"\u003e             PMID:                        28494216            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            First-trimester plasma nerve growth factor is lower in patients who subsequently develop preeclampsia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27513943            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study show evidence of variation in plasmatic beta-NGF expression during the progression of dementia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27802234            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF is functionally linked to beta-catenin, promoting the migration of human ovarian cancer cells via the WNT\/beta-catenin pathway.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27835587            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Varicella zoster virus DNA replication is regulated in part by an NGF pathway that is PI3-kinase-independent.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27683235            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Many studies indicate that the only presence of NGF is unable to generate cell carcinogenesis, both in normal neuronal and non-neuronal cells\/tissues. However, it cannot be excluded the possibility that the co-expression of NGF and pro-carcinogenic molecules might open to different consequence. [review]            \u003ca rel=\"nofollow\"\u003e             PMID:                        27439311            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the effect and underlying mechanisms of NGF\/BDNF on the production of NPW in PC12 cells and hypothalamus, is reported.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28249734            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These data support a role for islet NGF in fine-tuning insulin secretion.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27424144            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results of this study indicated that dysmenorrhea pain severity is partly genetically determined by the chromosome 1p13.2, near the nerve growth factor locu.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27454463            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Findings suggest that IL-1beta and TNF-alpha regulate Nerve Growth Factor expression and production in synovial macrophages and fibroblasts in osteoarthritic joints.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28677145            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results advance our knowledge of the conformational properties of proNGF and NGF and help provide a rationale for the diverse biological effects of NGF and proNGF at the molecular level.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28798232            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results of this study suggest that proNGF protein levels may augment the diagnostic accuracy of currently used CSF biomarker panels.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26825093            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Neuroimmune-endocrine events may lead to overactivity of sympathetic nervous system that triggers cascade of pathologic conditions in ovary in polycystic ovary syndrome (PCOS). Data suggest women with PCOS exhibit reduction of CRH and NGF; reduction of CRH\/NGF may be under influence of sympathetic nervous system and may reflect deficit of neuronal stress-adaptation in PCOS patients. (CRH = corticotropin releasing hormone)            \u003ca rel=\"nofollow\"\u003e             PMID:                        27908212            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The rare nerve growth factor-beta (NGFB) mutation R221W causes a selective loss of thinly myelinated fibers and especially unmyelinated C-fibers. Carriers of this mutation show altered pain sensation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27146986            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF expression was positively correlated with disease severity and visceral hypersensitivity in irritable bowel syndrome patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27862119            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            a stage-related modulation of beta-NGF and its receptors in the inflammatory process of OA            \u003ca rel=\"nofollow\"\u003e             PMID:                        28253191            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BDNF and NGF serum levels are reduced in the early and moderate glaucoma stages, suggesting the possibility that both factors could be further investigated as potential circulating biomarkers for the early detection of glaucoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28068360            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            overexpression of ARMS blocked NGF-mediated secretion, without affecting basal secretion, a decrease in ARMS resulted in potentiation. Similar effects were observed with synembryn-B, a protein that interacts directly with ARMS. Downstream of ARMS and synembryn-B are Galphaq and Trio proteins, which modulate the activity of Rac1 in response to NGF            \u003ca rel=\"nofollow\"\u003e             PMID:                        26966186            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data show that the standardized nerve growth factor (NGF) concentration was negatively correlated with continuous pain, neuropathic pain and total score, and the standardized S100 proteins S100A8\/A9 concentration was positively correlated with present pain intensity and continuous pain.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27936243            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results indicate that NGF inhibited CRT translocation induced by mitoxantrone. NGF effect on CRT translocation could have consequences in immunotherapy, potentially lessening the effectiveness of this type of treatment.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28260038            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF stimulates generation of neurons, but not neuronal progenitors from embryonic stem cells and affects the proportion of specific types of neurons in cultures of differentiating embryonic stem cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28364186            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF attenuates these responses-both in vivo and in vitro. Therefore, NGF therapy may represent a novel approach for the management of diabetic keratopathy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27978558            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF signaling pathway provides a potential target for developing molecularly targeted therapies            \u003ca rel=\"nofollow\"\u003e             PMID:                        27792755            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these data suggest a positive feedback loop through which NGF-mediated upregulation of p75(NTR) can contribute to the chemo-resistance of Triple negative breast cancer cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27577679            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Based on these current developments, the present review provides not only a broad overview of the biological effects of NGF-TrkA-p75NTR on cancer cells and their microenvironment, but also explains why NGF and its receptors are going to evoke major interest as promising therapeutic anti-cancer targets in the coming decade.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27264679            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF\/CD133 might be an effective and potent therapeutic target for pancreatic cancer metastasis, particularly in perineural invasion            \u003ca rel=\"nofollow\"\u003e             PMID:                        27654574            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The analysis of covariance (ANCOVA) indicated that the mean serum GDNF and NTF3 levels of ADHD patients were significantly higher than that of controls. However, serum BDNF and NGF levels did not show any significant differences between groups.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27561780            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            All patients had serum neurotrophin (NT-3, BDNF, NGF) concentrations determined.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27367919            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Serum NGF does not differentiate between recurrent acute pancreatitis and chronic pancreatitis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27020638            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        26962689            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Major depression patients had similar serum NGF to controls.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27008247            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            data demonstrate the involvement and modulation of nerve growth factor and its receptors in chronic obstructive pulmonary disease and in its staging            \u003ca rel=\"nofollow\"\u003e             PMID:                        26408608            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The present study showed that IL-17, in addition to stimulating an inflammatory response, negatively regulates the action of NGF and NGF R in the polar forms of the leprosy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26616164            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Locally increased estrogen levels and inflammation may cause increased NGF production in the uterus of patients with adenomyosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25519715            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The present study is the first to thoroughly assess the enhancement of neural differentiation of bone marrow mesenchymal stem cells following transfection with bFGF and NGF.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26572749            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data suggest MMP7 (matrix metalloproteinase 7) in follicular fluid cleaves proNGF (pro-nerve growth factor) in ovarian follicle; both MMP7 and proNGF appear to be products of granulosa cells; processing of proNGF to NGF appears to regulate apoptosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26457789            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF promotes renal fibrosis via TGF-beta1-signaling activation, suggesting that in kidney diseases high NGF serum levels could contribute to worsen renal fibrosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26066770            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study suggests that the circadian rhythm in the esophagus may be important for the mediation of and\/or the response to erosive damage in GERD patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26337663            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Intratumoral nerve growth factor expression is not associated with perineural invasion in patients with resected extrahepatic cholangiocarcinoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26547754            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF has a role in modulating trkANGFR\/p75NTR in alphaSMA-expressing conjunctival fibroblasts from human ocular cicatricial pemphigoid            \u003ca rel=\"nofollow\"\u003e             PMID:                        26569118            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF-induced tyrosine kinase independent TrkA signaling through CD44 is sufficient to maintain tumor aggressiveness in breast cancer            \u003ca rel=\"nofollow\"\u003e             PMID:                        25840418            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Urinary NGF, but not BDNF, levels decreased significantly after hyaluronic acid therapy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24614892            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915099603169,"sku":"BL-1705NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLYmAAMvJAAChZ5lbdyc990_c75d6eb2-746d-4e4e-9680-d17026bbf8dc.jpg?v=1685853222"},{"product_id":"recombinant-human-mouse-rat-bmp2-protein-bl-1735np","title":"Recombinant Human\/Mouse\/Rat BMP-2 Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human\/Mouse\/Rat Bone Morphogenetic Protein 2 is produced by our E.coli expression system and the target gene encoding Gln283-Arg396 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP12643\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBone Morphogenetic Protein 2; BMP-2; Bone Morphogenetic Protein 2A; BMP-2A; BMP2; BMP2A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBone Morphogenetic Protein-2 (BMP-2) is one of the bone-growth regulatory factors that belong to the transforming growth factor-beta (TGF-beta) superfamily of proteins. BMPs are synthesized as large precursor molecules, which are cleaved by proteolytic enzymes. The active form of BMP-2 can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e13.3 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e13 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 10mM HAc-NH4Ac, 4% D-Mannitol, pH 4.0.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.001 ng\/µg (0.01 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg\/ml.Dissolve the lyophilized protein in 50mM Acetic Acid.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGrowth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1\/5\/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathways such as ERK\/MAP kinase signaling cascade that regulates osteoblast differentiation. Stimulates also the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTGF-beta family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            1069           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            112261           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:650           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000368104           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        29386057            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            This work indicates that NELL-1, HMGB1, and CCN2 might enhance bone defect healing via the recruitment of endogenous cells and induction of vascularization and act via different processes than BMP2.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28463604            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Serum BMP2 and Smad4 levels in patients with senile osteoporotic fracture were significantly lower than those in normal controls            \u003ca rel=\"nofollow\"\u003e             PMID:                        29938690            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            conclude that SUMO3-tagged hBMP2 is more suited for generation of soluble form of the protein and addition of SUMO3 tag does not affect the functional activity of hBMP2            \u003ca rel=\"nofollow\"\u003e             PMID:                        29574511            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The present study identified a change in miR-22, miR-140, and BMP-2 expression in the synovial fluid of patients with osteoarthritis before and after arthroscopic debridement.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29429984            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The study revealed an enhanced sensitivity of aortic valve interstitial cells to osteogenic inductors in aortic stenosis patients, which indicates probable implication of OPN, OPG, and BMP2 genes in pathogenesis of aortic valve calcification.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29308559            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The rhBMP2 monomer and dimer were eluted at 0.9 M and 0.6 M NaCl, respectively. The alkaline phosphatase assay of rhBMP2 (0, 50, 100, 200, and 400 ng\/ml) was analyzed on C2C12 cells and maximum 200 ng\/ml activity was observed in dose dependent manner            \u003ca rel=\"nofollow\"\u003e             PMID:                        29333457            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In contrast to BMP-2, BMP-7 concomitantly inhibited the expression of profibrotic genes            \u003ca rel=\"nofollow\"\u003e             PMID:                        28102712            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The binding free energies indicate that ALK-3 preferably binds to BMP-2 instead of BMP-9. The structural analysis shows that ALK-3 binding with BMP-2 occurs in a perfectly symmetry pathway, whereas this symmetry is lost for possible ALK-3 interactions with BMP-9            \u003ca rel=\"nofollow\"\u003e             PMID:                        28869862            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results demonstrate the efficacy of HPP-GC hydrogel in minimizing the diffusive loss of rhBMP-2 from the implantation site, compared to the collagen hydroxyapatite scaffold.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28847606            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The in vitro results suggest that altered BMP2 regulatory function at rs1884302 may contribute to the etiology of sagittal nonsyndromic craniosynostosis. The in vivo results indicate that differences in regulatory activity depend on the presence of a C or T allele at rs1884302.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28985029            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Collectively, according to our study, rhIL-6 could induce the extracellular calcification and osteogenic differentiation of human artery smooth muscle cells through upregulating endogenous BMP2 in vitro. This may be one of the underlying mechanisms of the overwhelming vascular calcification in rheumartoid arthritis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28134597            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            HUCB-MSC transfected with mTAT\/PEI were shown to express more BMP-2 protein and mRNA.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28951869            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results showed that BMP2 activated SMAD1\/5\/8 phosphorylation and up-regulated BAMBI mRNA in human granulosa-lutein cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28578012            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BMP-2 can enhance HUVEC proliferation, migration and angiogenesis through P38, ERK and Akt\/m-TOR pathway.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27886213            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Study shows that recombinant human bone morphogenetic protein-2 activates hippo signaling through RASSF1 in esophageal cancer cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        27230238            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            SNPs in BMP2 can predict grade \u0026gt;\/= 2 or 3 RP after radiotherapy for NSCLC and improve the predictive power of MLD model.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28574846            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CTGF and BMP2 are induced following myocardial ischemia in mice and humans.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28460577            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Missense mutations in COL6A1, COL11A2, FGFR1, and BMP2 genetically predispose patients to ossification of posterior longitudinal ligaments.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27246988            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Computational analysis on conformational dynamics of BMP-2 has been presented.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27426435            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            there was a significant association in men between BMP2 genetic variant (rs235756) and hypertension in the genetically homogeneous Finnish population; no significant association between BMP2 rs235768 (A\u0026gt;T) and hypertension was found            \u003ca rel=\"nofollow\"\u003e             PMID:                        29390526            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Adding NMP as an adjunct to rhBMP-2-coated BCP produced inconsistent effects on bone regeneration, resulting in no significant benefit compared to controls.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28680881            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            observations regarding the dysregulation of these gatekeepers of neuronal viability may have important implications in understanding the iAbeta1-42 mediated effects observed in AD            \u003ca rel=\"nofollow\"\u003e             PMID:                        29470488            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study demonstrates that viscous collagen gel can be an effective carrier for rhBMP-2 delivery into surgical sites, and that the injectable rhBMP-2-containing collagen gel may be applied for the enhancement of tendon-bone interface healing            \u003ca rel=\"nofollow\"\u003e             PMID:                        26177709            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Synergistic effects of BMP-2, BMP-6 or BMP-7 with human plasma fibronectin onto hydroxyapatite coatings.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28434979            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High-dose recombinant human bone morphogenetic protein-2 impacts histological and biomechanical properties of a cervical spine fusion segment: results from a sheep model.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26053675            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Report osteoblast-like transformation of epithelial breast cancer cells that have undergone epithelial-mesenchymal transition followed by bone morphogenetic protein-2 stimulation. RUNX2 functions as a master mediator of this process.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27806311            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Taken together, our results suggest that DHCA may be developed as an efficient therapeutic for osteoporosis by regulating osteoblastogenesis through its estrogenic effects.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29253565            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BMP2-transduced BMSCs can maintain the chondrocyte-like phenotype in PRP gel in vitro, and the combined use of these two agents can significantly promote repair of the degenerated discs in vivo            \u003ca rel=\"nofollow\"\u003e             PMID:                        26169838            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these results suggest that the BMP2 gene polymorphism may be related to the development of allograft rejection and graft dysfunction in kidney transplant recipients            \u003ca rel=\"nofollow\"\u003e             PMID:                        28583517            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data show that the GREMLIN 2 (GREM2) expression during Induced Pluripotent Stem Cell (hiPS) cell cardiac differentiation follows the expression pattern of cardiac-specific genes.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28125926            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results identify a novel 4671-bp tandem duplication downstream of BMP2, which is associated with brachydactyly type A2 . The duplication highly overlaps the sequences reported previously but has a different breakpoint and a different flanking microhomology.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29129813            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            miR-106b inhibited osteoblastic differentiation and bone formation partly through directly targeting bone morphogenetic protein 2.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28108317            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BMP2 decreases gap junction intercellular communication of luteinized human granulosa cells by downregulating Cx43 expression through an ALK2\/ALK3-mediated SMAD-dependent signaling pathway.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27986931            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BMP2 also requires Src for filamentous actin polymerization in Tgfbr3(-\/-) epicardial cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26645362            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The deletion contained 17 protein coding genes including PROKR2 and BMP2, both of which are expressed during embryological development of the pituitary gland. PROKR2 mutations have been associated with hypopituitarism but a heterozygous deletion of this gene with hypopituitarism is a novel observation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28586151            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            both bone morphogenetic protein 2 (BMP2) and BMP6 are proangiogenic in vitro and ex vivo and that the BMP type I receptors, activin receptor-like kinase 3 (ALK3) and ALK2, play crucial and distinct roles in this process.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28733457            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            sequential presentation of PDGF to BMP-2 led to increased tubule formation over simultaneous delivery of these growth factors.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27650131            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Bone Morphogenetic Protein-2, But Not Mesenchymal Stromal Cells, Exert Regenerative Effects on Canine and Human Nucleus Pulposus Cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        27829314            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The structure of Grem2-GDF5 complex has revealed a number of key findings for DAN-family mediated BMP2 inhibition.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27524626            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Bioluminescence imaging reveals increased MSC survival when implanted in BMP-2 PAHs.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27581621            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Bone morphogenetic protein 2 promotes osteogenesis of bone marrow stromal cells in type 2 diabetic rats via the Wnt signaling pathway            \u003ca rel=\"nofollow\"\u003e             PMID:                        27702654            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            monocytes interact specifically with Chitosan-Fibrinogen (Ch-Fg) via TLR-4, triggering particular intracellular signalling pathways (ERK and JNK, but not p38), downstream of TLR-4. Functionally, Ch-Fg induced monocytes to produce the osteogenic mediator BMP-2.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27856281            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study showed that si-Grem2 increased the BMP-2-induced osteogenic differentiation of hBMSCs via the BMP-2\/Smad\/Runx2 pathway.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27335248            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Low doses of IL1B activate the BMP\/Smad signaling pathway to promote the osteogenesis of periodontal ligament stem cells, but higher doses of IL1B inhibit BMP\/Smad signaling through the activation of NF-kappaB and MAPK signaling, inhibiting osteogenesis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27415426            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Increased miR-93-5p in trauma-induced osteonecrosis of the femoral head patients inhibited osteogenic differentiation, which may be associated with BMP-2 reduction.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28797104            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            RANKL promotes VC by inducing BMP-2 release from HAECs            \u003ca rel=\"nofollow\"\u003e             PMID:                        27339040            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            KDM5A-mediated H3K4me3 modification participated in the etiology of osteoporosis and may provide new strategies to improve the clinical efficacy of BMP2 in osteoporotic conditions.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27512956            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            fabricated scaffolds were well coated with DOPA as well as grafted with rhBMP2 at a quantity of 22.7+\/-5ng when treatment with 100ng\/ml rhBMP2 and 153.3+\/-2.4ng when treated with 500ng\/ml rhBMP2. This grafting enables rhBMP2 to be released in a sustained pattern.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26868173            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data suggest pituitary cells secrete factor (TSP1) that binds to and inhibits action of BMP2 and BMP4; von Willebrand type C domain of TSP1 is likely responsible for this BMP2\/4-binding activity. These studies were initially conducted using cultured cells from ovine pituitary gland and mouse cell line; interactions were confirmed using recombinant human proteins. (TSP1 = thrombospondin-1; BMP = bone morphogenetic protein)            \u003ca rel=\"nofollow\"\u003e             PMID:                        28747434            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915097473249,"sku":"BL-1735NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLRCALMHuAACU0OpiwKU856_6860bfbb-e830-4f52-816d-7e158765249a.jpg?v=1685853139"},{"product_id":"recombinant-human-tgfb2-protein-bl-1740np","title":"Recombinant Human TGF-beta 2 Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Transforming Growth Factor Beta 2 is produced by our Mammalian expression system and the target gene encoding Ala303-Ser414 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP61812\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTransforming growth factor beta-2; TGFB2; Polyergin; G-TSF; Glioblastoma-derived T-cell suppressor factor; Cetermin; BSC-1 cell growth inhibitor; TGF-beta-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTransforming growth factor beta-2 (TGF-β2)  is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e12.7 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e12 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 4mM HCl.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.001 ng\/µg (0.01 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBiologically active. Please contact us to obtain bioactivity data.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg\/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTransforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.; Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32\/GARP, that control activation of TGF-beta-2.; Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32\/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus. Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix.; [Transforming growth factor beta-2]: Secreted.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTGF-beta family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            11768           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            190220           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:7042           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        30160133            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            Importantly, high expression levels of HIF-1alpha\/TGF-beta2\/GLI2 correlated robustly with the patient relapse following chemotherapy, highlighting a potential biomarker and therapeutic target for chemoresistance in colorectal cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29891662            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these data suggest that miR-592 may exert it suppressive role in breast cancer, at least in part, by targeting TGFbeta-2, and that miR-592 may be a novel target for breast cancer treatment            \u003ca rel=\"nofollow\"\u003e             PMID:                        29039599            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            MicroRNA-486-5p suppresses TGFB2-induced proliferation, invasion and epithelial-mesenchymal transition of lens epithelial cells by targeting Smad2.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29229876            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results show that TGF-beta2 is highly expressed in glioma and correlated with poor prognosis in glioma patients. Further findings elucidate a potential mechanism of autophagy-associated glioma invasion that TGF-beta2 could initiate autophagy via Smad and non-Smad pathway to promote glioma cells' invasion.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29145888            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Up-regulation of TGF-beta2 showed a strong association with muscle invasion in bladder cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28261684            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Report early adaptive drug-escape in EGFR-mutant lung tumor cells dependent on TGFbeta2-bioenergetics-mitochondrial priming.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27852038            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The expression of TGFB2 obtained by microarray analysis was consistent with that of RT-PCR. Ion transport could be affected promptly after ANP treatment, and subsequently, the cytolysis of vein endothelial cells may be promoted and endothelial permeability would be enhanced, followed by activated immune responses.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29279524            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            4.7 Mb deletion encompassing TGFB2 is associated with features of Loeys-Dietz syndrome and osteoporosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28544325            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            results imply that the interaction of matrix AGEs with RAGE plays a role in the TGFbeta2-mediated EMT of lens epithelial cells and suggest that the blockade of RAGE could be a strategy to prevent PCO and other age-associated fibrosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27263094            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            results support that the regulation of miR-30b by VEGF in HUVEC is important for capillary morphogenesis, as increased miR-30b expression inhibits capillary morphogenesis through enhanced expression of TGFbeta2            \u003ca rel=\"nofollow\"\u003e             PMID:                        28977001            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data suggest that TGFB2 (the most abundant growth factor in human milk) binding to Tgfb2r elicits robust\/rapid response in small intestinal mucosal cells leading to stimulation of Egr1 transport to nucleus and cell differentiation; more than 15 Wnt signaling pathway genes have Egr1 binding sites\/response elements; Egr1 binds to Axin1 promoter and functionally activates gene expression. (Axin1 = axis inhibition protein 1)            \u003ca rel=\"nofollow\"\u003e             PMID:                        27697743            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        28640846            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High TGFbeta2 expression is associated with oral cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27803052            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TGF-beta2 is a new regulatory factor for KCC2 functional activation and membrane trafficking.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27505893            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our data expand the phenotype of Loeys-Dietz syndrome type 4 : we confirm that TGFb2 mutations are responsible for true Loeys-Dietz (LDS) syndrome with non-specific features of connective tissue disorders and diffuse vascular lesions            \u003ca rel=\"nofollow\"\u003e             PMID:                        27440102            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TGF-beta signaling regulated cell growth of cancer associated fibroblasts.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27880067            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Localized constitutive expression and release of TGF-beta2 by TM cells may promote or exacerbate elevation of IOP in POAG.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26743044            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Advanced glycation endproduct in the lens capsule promote the TGFbeta2-mediated fibrosis of lens epithelial cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26853893            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our study suggests that lnc-ATB promotes tumor progression by interacting with miR-141-3p and that Lnc-ATB may be a valuable prognostic predictor for GC. In conclusion, the positive feedback loop of lnc-ATB\/miR-141-3p\/TGF-beta2 may be a potential therapeutic target for the treatment of GC.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28115163            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            decorin can alter the bioactivity of TGF-beta2 on human myoblast migration            \u003ca rel=\"nofollow\"\u003e             PMID:                        27644884            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            findings indicate that lncRNA-ATB governs the autocrine secretion of TGF-beta2 in KFs, at least in part, by downregulating the expression level of ZNF217 via miR-200c, suggesting a signaling axis consisting of lncRNA-ATB\/miR-200c\/ZNF217\/TGF-beta2            \u003ca rel=\"nofollow\"\u003e             PMID:                        27090737            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            association between SNP rs6658835 in TGF-beta2 and conotruncal heart defects            \u003ca rel=\"nofollow\"\u003e             PMID:                        27564654            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            miR-422a directly targeted TGFbeta2 and regulated its expression and the activation of downstream molecules, smad2 and smad3 in osteosarcoma cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27779704            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            miR-378a expression is associated with its methylation status in TGF-beta1-treated cells, and epigenetically-regulated miR-378a inhibits TGF-beta1-induced hepatic stellate cells activation, at least in part, via TGF-beta2.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27855367            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            we detected and verified a list of differentially expressed microRNAs in PE placentas by HTS and qRT-PCR, and provided preliminary evidence for the role of miR-193b-3p in the pathogenesis of preeclampsia by targeting TGF-beta2.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26822621            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Likely pathogenic variants included a TGFB2 variant in one patient and a SMAD3 variant in another. These variants have been reported previously in individuals with similar phenotypes. Variants of uncertain significance of particular interest included novel variants in MYLK and MFAP5, which were identified in a third patient            \u003ca rel=\"nofollow\"\u003e             PMID:                        26854089            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results provide evidence that miR-148a decreases the expression of TGFbeta2 and SMAD2 in gastric cancer cells through binding to their 3'UTRs.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26983401            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TGF-beta2 induces epithelial-mesenchymal transition by activating the PI3K\/Akt\/mTOR signaling pathway in cultured human lens epithelial cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26647778            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Human retinal pigment epithelial cells were cultured in the presence or absence of TGF-beta2, and reverse-transcription quantitative PCR was performed to determine the mRNA expression of IDO and Nrf2.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26676103            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TGF-beta2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK\/AP-1-signaling and augments invasiveness of Theileria-transformed macrophages.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26511382            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In conclusion, each of the DPP-4 inhibitors may have unique drug-specific effects.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26826382            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Active CREB1 promotes a malignant TGFbeta2 autocrine loop in glioblastoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25084773            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Comparison of the aqueous humor TGF-beta2 level between patients with open-angle glaucoma (OAG) and controls provides direct evidence for the role of TGF-beta2 in the etiology of OAG. (meta-analysis)            \u003ca rel=\"nofollow\"\u003e             PMID:                        26019480            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            there is a borderline significant association between higher mean TGF-beta2 levels in breast milk and more severe pathologic diagnoses            \u003ca rel=\"nofollow\"\u003e             PMID:                        25604865            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2, indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in renal cell carcinoma            \u003ca rel=\"nofollow\"\u003e             PMID:                        25813153            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TGFbeta2 is a key growth promoter of CD44(hi) cells that survived chemotherapy and also is a growth inhibitor of cells that survived hypoxia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26340918            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            MicroRNA-153 inhibits osteosarcoma cells proliferation and invasion by targeting TGF-beta2            \u003ca rel=\"nofollow\"\u003e             PMID:                        25793604            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High expression of TGFB2 is associated with melanoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25743834            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data suggest that the intrinsic transforming growth factor beta 2-triggered stromal cell-derived factor-1-C-X-C chemokine receptor-4 signaling is crucial for drug resistance in bone marrow (BM)-slow-cycling disseminated tumor cells (DTCs).            \u003ca rel=\"nofollow\"\u003e             PMID:                        25504440            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Here, we show that increased TGF-beta2 signaling through ALK5 plays a role in hypoxia-induced redifferentiation of chondrocytes.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25621374            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TGF-beta2 secretion from retinal pigmented epithelium decreases with polarization and becomes apically oriented            \u003ca rel=\"nofollow\"\u003e             PMID:                        25496702            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            glycated collagen in the cardiac interstitium triggers an autocrine TGF-beta2 signaling pathway that stimulates alpha11 integrin expression through Smad2\/3 binding elements in the alpha11 integrin promoter            \u003ca rel=\"nofollow\"\u003e             PMID:                        24962729            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these results revealed no correlation between the normalized expression of TGF-beta2, TGF-betaRI, or TGF-betaRII and EDSS scores            \u003ca rel=\"nofollow\"\u003e             PMID:                        26037400            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these data shed light on previously unrecognized roles of Mkx in tendinopathy, tenogenesis, and tendon repair as well as in regulating the TGFbeta pathway.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25332192            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High levels of furin, TNF-alpha and TGF-beta2 may be the reason of proceeding decidualization, placentation, and prevention from abortion, in spite of terminating the fetal life.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26065233            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TGF-beta2 therefore promotes the adhesion and invasiveness of virulent macrophages by modulating COX2, EP4, and PKIG transcription to initiate a prostaglandin E2 (PGE2)-driven autostimulatory loop that augments PKA and EPAC activities.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25690101            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TGF-beta2 induced MYOC expression and secretion in human primary cultured trabecular meshwork cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        25197353            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data indicate that TGF-beta2 (TGFB2) and TGF beta type III receptor (TGFBR3) are target genes of miR-193b in chondrogenesis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25728278            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            ALDH1 and TGFbeta2 play important roles in the development of breast cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25120797            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915097440481,"sku":"BL-1740NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/rB9Eh2Pczt-AJgsjAACwWolseRo109_7227e88a-58c6-4379-82e9-8302329bcede.jpg?v=1685853138"},{"product_id":"recombinant-human-kgf-protein-bl-1760np","title":"Recombinant Human KGF Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Fibroblast Growth Factor 7\/Keratinocyte Growth Factor is produced by our E.coli expression system and the target gene encoding Cys32-Thr194 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP21781\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFibroblast growth factor 7; FGF-7; Heparin-binding growth factor 7; HBGF-7; Keratinocyte growth factor; FGF7; KGF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFibroblast growth factor 7 (FGF7) is a secreted protein which is mainly located in epithelial cells and belongs to the heparin-binding growth factors family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF7 is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. It is possible major paracrine effector of normal epithelial cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e18.9 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e17 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 20mM Tris，1mM EDTA，5% Trehalose, 0.02% Tween 80, pH 8.0.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by SEC-HPLC. (Regularly tested)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg\/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003ePlays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eHeparin-binding growth factors family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            3685           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            148180           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:2252           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000267843           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        29970688            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            Findings suggest that excessive KGF and KGFR synthesis may contribute to the hyperproliferative state in cholesteatoma and could explain the pathological difference between cholesteatoma and CSOM.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29556625            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results suggest that fibroblast growth factor 7 may stimulate endometrial stromal cells proliferation and insulin-like growth factor-binding protein 1 and prolactin expressions through ERK and JNK signal pathways in an autocrine manner.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28270036            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The stability and activity of rhKGF mutants were analyzed using GROMACS molecular dynamics (MD) simulations and docking tools, respectively. The results showed that N159S (N105S in rhKGF sequence) and I172V (I118V in rhKGF) substitutions caused an increased stability and affinity of the rhKGF to Fibroblast growth factor receptor 2 (FGFR2).            \u003ca rel=\"nofollow\"\u003e             PMID:                        28093295            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Tregs isolated from human lung tissue can be stimulated ex vivo to induce kgf expression.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28296468            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            FGF7 stimulation of cell invasion and migration was partially suppressed by the FGFR2 knockdown. In addition, FGF7\/FGFR2 upregulated THBS1, and cell invasion and migration were decreased by knockdown of THBS1            \u003ca rel=\"nofollow\"\u003e             PMID:                        28339036            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Suppression of miR-219-5p may benefit the liver regeneration and prevent cirrhosis through increasing KGF.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27855391            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study evaluated the expression of FGF7, AhR, and CYP1A1 in colorectal cancer cells and revealed a new mechanism by which KGF promotes cell proliferation through the AhR-cyclin D1 pathway in colon cancer cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26514676            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            KGF expression induced epithelial cell proliferation, reaching a peak level at day 4 and then decreased later, while in the long-term model, KGF expression in the EAC led to middle ear cholesteatoma formation            \u003ca rel=\"nofollow\"\u003e             PMID:                        25138153            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In the current study, conditioned media and chemically defined media with recombinant human keratinocyte growth factor (KGF) could induce hUC-MSC differentiation into sweat gland-like cells (SGCs).            \u003ca rel=\"nofollow\"\u003e             PMID:                        26574554            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Coexpression of KGF and MMP-9 in gastric cancer could be a useful prognostic factor, and MMP-9 might also serve as a novel target for both prognostic prediction and therapeutics.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26350198            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            FGF7 over expression is associated with advanced clinical features in patients with upper tract and bladder urothelial carcinoma            \u003ca rel=\"nofollow\"\u003e             PMID:                        25623741            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data indicate the key roles played, on the melanosome transfer in normal skin, by KGF\/FGF7 released by dermal fibroblasts and by its receptor KGFR\/FGFR2b expressed and activated on the epidermal keratinocytes.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25313018            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            First evidence of a role of FGF7 in the regulation of sequential steps of the autophagic process and strengthen the hypothesis of a direct interplay between autophagy and differentiation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24577098            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            An SNP in FGF7 is associated with an increased risk of chronic obstructive pulmonary disease.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22796760            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These findings indicate that topically delivered KGF-1 DNA plasmid can increase epithelial thickness and strength, demonstrating the potential of this approach to restore compromised skin.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24434934            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Recombinant keratinocyte growth factor 1 in tobacco potentially promotes wound healing in diabetic rats.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24783215            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Sustained effect of KGF on cell survival and proliferation could be attributed to its ability to inhibit p53, retinoblastoma, caspases, and p27(kip) functions in apoptosis and cell cycle arrest.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24426773            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            FGF7 stimulates osteogenic differentiation, but not proliferation, in embryonic stem cells, by activating ERK\/Runx2 signaling.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24026476            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This paper provides an overview of the knowledge on molecular properties, biological functions and the ecent findings on clinical application of EGF7. [review]            \u003ca rel=\"nofollow\"\u003e             PMID:                        24188496            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High FGF7 expression is associated with ameloblastoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24002438            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            IL-19 is important for cutaneous wound healing because it upregulates KGF expression.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23582717            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            FGF7 supports hematopoietic stem and progenitor cells and leukemia-initiating cells indirectly via FGFR2IIIb expressed on stromal cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24051090            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The aim of this study was to determine whether the K-sam gene and keratinocyte growth factor (KGF) expression may be used to identify malignant tumors with a poor prognosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23545898            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            KGF could up-regulate IL-7 expression through the STAT1\/IRF-1, IRF-2 signaling pathway, which is a new insight in potential effects of KGF on the intestinal mucosal immune system.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23554911            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The LTA downstream segment alternate core promoter was active only after specific cellular stimulation and was the major promoter used when human T cells were stimulated with TGF-beta1 and fibroblast growth factor-7.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23547113            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Increased KGF expression promotes fibroblast activation in a double paracrine manner resulting in cutaneous fibrosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23096718            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            results implicate pericryptal myofibroblast-derived paracrine KGF and largely autocrine amphiregulin in the upregulation of claudin-2 in Caco-2 epithelial monolayers and consequent disruption of tight junction integrity            \u003ca rel=\"nofollow\"\u003e             PMID:                        22946653            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia\/reperfusion in vitro and in vivo.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22949940            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the activation of the stromal fibroblasts present in the pathological tissue, and the consequent increased secretion of KGF, play a crucial role in the deregulation of the epidermal proliferation and differentiation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22481617            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these data suggest that FGF7 is a novel regulator of CYP7A1 expression in hepatocytes and may prevent hepatocytes from accumulating toxic bile acids during liver injury and fibrosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22713451            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Repression of Ink4a in aged (ETPs) Early T-cell progenitors results in their partial rejuvenation and this can be accomplished by in vivo fibroblast growth factor 7 administration.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22555975            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In COPD, SNPs (rs12591300 and rs4480740) were significantly associated with COPD in an independent population (combined p values of 7.9E-7 and 2.8E-6). Increased lung tissue FGF7 expression was associated with worse measures of lung function.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21921092            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            FGF7 enhanced keratinocyte proliferation and its expression was increased when NCTC 2544 cells were subjected to treatments with plantaricin A preparations or hyaluronic acid.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21782870            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Carcinoma-associated fibroblasts promotes the proliferation of a lingual carcinoma cell line by secreting keratinocyte growth factor.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21340484            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            KGF may have a role in ameliorating radiation-induced pulmonary injury in rats            \u003ca rel=\"nofollow\"\u003e             PMID:                        21436609            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results suggest that the growth factors HGF and KGF may play a role in enhancing IL-1-stimulated production of IL-8 by epithelial cells during mucosal inflammations.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21082280            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            KGF increases pigment production and deposition in melanocytes in vitro and in vivo            \u003ca rel=\"nofollow\"\u003e             PMID:                        19780816            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The upregulation of KGF\/KGFR might induce the formation of rete ridges and hyperpigmentation in solar lentigines.            \u003ca rel=\"nofollow\"\u003e             PMID:                        20620021            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Modulation of calprotectin in human keratinocytes by keratinocyte growth factor and interleukin-1alpha.            \u003ca rel=\"nofollow\"\u003e             PMID:                        20065999            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the expression of keratinocyte growth factor (KGF) and keratinocyte growth factor receptor (KGFR) in Hela cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        17593825            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            KGF and KGFR are both expressed in CaSki cells. Autocrine and recombinant human KGF affect cell proliferation and migration.            \u003ca rel=\"nofollow\"\u003e             PMID:                        17953372            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            keratinocyte growth factor works via an inducible lentivirus to protect bone marrow cells against bleomycin-induced pulmonary fibrosis            \u003ca rel=\"nofollow\"\u003e             PMID:                        19956603            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The goal of this study was to elucidate the control mechanisms by which exogenous proteins regulate keratinocyte growth factor (KGF) expression in fibroblasts adhered to differing substrates.            \u003ca rel=\"nofollow\"\u003e             PMID:                        20036421            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The effect of KGF on limbal epithelial cell growth is mediated by upregulation of DeltaNp63alpha through the p38 pathway.            \u003ca rel=\"nofollow\"\u003e             PMID:                        19920075            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            KGF induced proliferation but did not cause significant differentiation of 3 hematopoietic cell lines and bone marrow cells transduced with human K-sam.            \u003ca rel=\"nofollow\"\u003e             PMID:                        11937263            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            play important roles in lung development, lung inflammation, and repair.            \u003ca rel=\"nofollow\"\u003e             PMID:                        11943656            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            keratinocyte growth factor (KGF), a key stimulator of epithelial cell proliferation during wound healing, preferentially binds to collagens I, III, and VI.            \u003ca rel=\"nofollow\"\u003e             PMID:                        11973338            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            KGF may hold promise for the treatment of very premature neonates with bronchopulmonary dysplasia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        12016100            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Following activation by KGF binding, KGF and the KGF receptor remain associated in active complexes through the endocytic pathway, which is described.            \u003ca rel=\"nofollow\"\u003e             PMID:                        12122441            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915097637089,"sku":"BL-1760NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLYWAYrEfAADG8FUuZrA829_0b118559-7c4c-4847-8c40-d199de7f7f9f.jpg?v=1685853146"},{"product_id":"recombinant-mouse-c5-protein-bl-1792np","title":"Recombinant Mouse C5 Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Mouse Complement Component C5 is produced by our E.coli expression system and the target gene encoding Asn679-Arg755 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003ca title=\"P06684\" target=\"_blank\" href=\"https:\/\/www.uniprot.org\/uniprotkb\/P06684\/entry\"\u003eP06684\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eComplement C5; Hemolytic Complement; C5; Hc\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eMouse Complement C5 (C5a) is a glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. C5a is a 77 amino acid peptide that is created by the C5a convertase proteolytic cleavage of C5 αchain in the classical and alternative complement pathway (C4b2a3b, C3bBb3b). Mouse C5a has fourαhelices, plus three intra-chain disulfide bonds that form a triple loop structure. C5a functions via G-protein coupled receptor (GPCR) (C5aR\/CD88). C5a is a potent chemoattractant and anaphylatoxin that acts on all classes of leukocytes and on many other cell types including endothelial, smooth muscle, kidney, liver, and neural cells. It mediates IL-8 release from bronchial epithelial cells. It also triggers an oxidative burst in macrophages and neutrophils, causing release of histamine in basophils and mast cells. C5a anaphylatoxin activity on hepatocytes results indirectly from interaction with nonparenchymal cell via prostanoid secretion. Mouse C5a shares 60% and 82% sequence identity to human and rat C5a, respectively.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e9 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e12 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 20mM PB, 350mM NaCl, pH 7.5.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915031314657,"sku":"BL-1792NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLSSAK0z6AACjXKLFiCY828_78c3d24f-4a4e-4136-a6ae-a589fe32746f.jpg?v=1685850962"},{"product_id":"recombinant-human-pro-ngf-protein-bl-1793np","title":"Recombinant Human pro-Beta NGF Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human pro-Nerve Growth Factor is produced by our E.coli expression system and the target gene encoding Glu19-Ala241 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP01138\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBeta-Nerve Growth Factor; Beta-NGF; NGF; NGFB;β-NGF; pro-Beta NGF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e25 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e30 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl,500mM NaCl,5%Trehalose,5%Mannitol,0.01%tween80,1mM EDTA,pH8.0.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg\/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and\/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted. Endosome lumen.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNGF-beta family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            7808           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            162030           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:4803           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000358525           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        29527653            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            Single nucleotide polymorphisms in NGF gene (rs6330) and NGFR gene (rs2072446 and rs734194) are associated with ischemic stroke. The NGF rs6330*T and NGFR rs2072446*T minor alleles might be nominated as a risk factor for developing ischemic stroke and NGFR rs734194*G minor allele as a protective against this disease at least in Armenian population            \u003ca rel=\"nofollow\"\u003e             PMID:                        29499660            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Neurotrophic factors and hippocampal activity in PTSD            \u003ca rel=\"nofollow\"\u003e             PMID:                        29799860            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            SNRPA may contribute to GC progression via NGF and could be a prognostic biomarker for GC.            \u003ca rel=\"nofollow\"\u003e             PMID:                        30039889            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results show that NGF signalling is strongly linked to pathological and regenerative processes in human teeth.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28465581            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results suggest an interaction between NGF, GDNF and MMP-9 during the transition to malignancy in prostate cancer (PC). Also this interaction may involve in regulating PC cell differentiation, tumor invasion, progression, and the agressiveness of PC.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28237042            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the anti-tumor activity of oleuropein against hepatocellular carcinoma could be attributed to influencing the pro-NGF\/NGF balance via affecting MMP-7 activity without affecting the gene expression of NGF            \u003ca rel=\"nofollow\"\u003e             PMID:                        29476769            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            co-expression patterns of NGF and heme oxygenase-1 might be used as prognostic indicators for gastric carcinoma patients            \u003ca rel=\"nofollow\"\u003e             PMID:                        28679437            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This review will briefly address the peripheral and central sensitization mechanisms of airway neurons and will then focus on NGF signaling and its role in cough hypersensitivity.[review]            \u003ca rel=\"nofollow\"\u003e             PMID:                        28494216            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            First-trimester plasma nerve growth factor is lower in patients who subsequently develop preeclampsia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27513943            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study show evidence of variation in plasmatic beta-NGF expression during the progression of dementia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27802234            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF is functionally linked to beta-catenin, promoting the migration of human ovarian cancer cells via the WNT\/beta-catenin pathway.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27835587            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Varicella zoster virus DNA replication is regulated in part by an NGF pathway that is PI3-kinase-independent.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27683235            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Many studies indicate that the only presence of NGF is unable to generate cell carcinogenesis, both in normal neuronal and non-neuronal cells\/tissues. However, it cannot be excluded the possibility that the co-expression of NGF and pro-carcinogenic molecules might open to different consequence. [review]            \u003ca rel=\"nofollow\"\u003e             PMID:                        27439311            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the effect and underlying mechanisms of NGF\/BDNF on the production of NPW in PC12 cells and hypothalamus, is reported.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28249734            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These data support a role for islet NGF in fine-tuning insulin secretion.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27424144            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results of this study indicated that dysmenorrhea pain severity is partly genetically determined by the chromosome 1p13.2, near the nerve growth factor locu.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27454463            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Findings suggest that IL-1beta and TNF-alpha regulate Nerve Growth Factor expression and production in synovial macrophages and fibroblasts in osteoarthritic joints.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28677145            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results advance our knowledge of the conformational properties of proNGF and NGF and help provide a rationale for the diverse biological effects of NGF and proNGF at the molecular level.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28798232            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results of this study suggest that proNGF protein levels may augment the diagnostic accuracy of currently used CSF biomarker panels.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26825093            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Neuroimmune-endocrine events may lead to overactivity of sympathetic nervous system that triggers cascade of pathologic conditions in ovary in polycystic ovary syndrome (PCOS). Data suggest women with PCOS exhibit reduction of CRH and NGF; reduction of CRH\/NGF may be under influence of sympathetic nervous system and may reflect deficit of neuronal stress-adaptation in PCOS patients. (CRH = corticotropin releasing hormone)            \u003ca rel=\"nofollow\"\u003e             PMID:                        27908212            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The rare nerve growth factor-beta (NGFB) mutation R221W causes a selective loss of thinly myelinated fibers and especially unmyelinated C-fibers. Carriers of this mutation show altered pain sensation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27146986            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF expression was positively correlated with disease severity and visceral hypersensitivity in irritable bowel syndrome patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27862119            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            a stage-related modulation of beta-NGF and its receptors in the inflammatory process of OA            \u003ca rel=\"nofollow\"\u003e             PMID:                        28253191            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BDNF and NGF serum levels are reduced in the early and moderate glaucoma stages, suggesting the possibility that both factors could be further investigated as potential circulating biomarkers for the early detection of glaucoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28068360            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            overexpression of ARMS blocked NGF-mediated secretion, without affecting basal secretion, a decrease in ARMS resulted in potentiation. Similar effects were observed with synembryn-B, a protein that interacts directly with ARMS. Downstream of ARMS and synembryn-B are Galphaq and Trio proteins, which modulate the activity of Rac1 in response to NGF            \u003ca rel=\"nofollow\"\u003e             PMID:                        26966186            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data show that the standardized nerve growth factor (NGF) concentration was negatively correlated with continuous pain, neuropathic pain and total score, and the standardized S100 proteins S100A8\/A9 concentration was positively correlated with present pain intensity and continuous pain.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27936243            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results indicate that NGF inhibited CRT translocation induced by mitoxantrone. NGF effect on CRT translocation could have consequences in immunotherapy, potentially lessening the effectiveness of this type of treatment.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28260038            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF stimulates generation of neurons, but not neuronal progenitors from embryonic stem cells and affects the proportion of specific types of neurons in cultures of differentiating embryonic stem cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28364186            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF attenuates these responses-both in vivo and in vitro. Therefore, NGF therapy may represent a novel approach for the management of diabetic keratopathy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27978558            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF signaling pathway provides a potential target for developing molecularly targeted therapies            \u003ca rel=\"nofollow\"\u003e             PMID:                        27792755            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these data suggest a positive feedback loop through which NGF-mediated upregulation of p75(NTR) can contribute to the chemo-resistance of Triple negative breast cancer cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27577679            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Based on these current developments, the present review provides not only a broad overview of the biological effects of NGF-TrkA-p75NTR on cancer cells and their microenvironment, but also explains why NGF and its receptors are going to evoke major interest as promising therapeutic anti-cancer targets in the coming decade.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27264679            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF\/CD133 might be an effective and potent therapeutic target for pancreatic cancer metastasis, particularly in perineural invasion            \u003ca rel=\"nofollow\"\u003e             PMID:                        27654574            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The analysis of covariance (ANCOVA) indicated that the mean serum GDNF and NTF3 levels of ADHD patients were significantly higher than that of controls. However, serum BDNF and NGF levels did not show any significant differences between groups.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27561780            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            All patients had serum neurotrophin (NT-3, BDNF, NGF) concentrations determined.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27367919            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Serum NGF does not differentiate between recurrent acute pancreatitis and chronic pancreatitis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27020638            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        26962689            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Major depression patients had similar serum NGF to controls.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27008247            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            data demonstrate the involvement and modulation of nerve growth factor and its receptors in chronic obstructive pulmonary disease and in its staging            \u003ca rel=\"nofollow\"\u003e             PMID:                        26408608            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The present study showed that IL-17, in addition to stimulating an inflammatory response, negatively regulates the action of NGF and NGF R in the polar forms of the leprosy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26616164            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Locally increased estrogen levels and inflammation may cause increased NGF production in the uterus of patients with adenomyosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25519715            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The present study is the first to thoroughly assess the enhancement of neural differentiation of bone marrow mesenchymal stem cells following transfection with bFGF and NGF.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26572749            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data suggest MMP7 (matrix metalloproteinase 7) in follicular fluid cleaves proNGF (pro-nerve growth factor) in ovarian follicle; both MMP7 and proNGF appear to be products of granulosa cells; processing of proNGF to NGF appears to regulate apoptosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26457789            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF promotes renal fibrosis via TGF-beta1-signaling activation, suggesting that in kidney diseases high NGF serum levels could contribute to worsen renal fibrosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26066770            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study suggests that the circadian rhythm in the esophagus may be important for the mediation of and\/or the response to erosive damage in GERD patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26337663            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Intratumoral nerve growth factor expression is not associated with perineural invasion in patients with resected extrahepatic cholangiocarcinoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26547754            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF has a role in modulating trkANGFR\/p75NTR in alphaSMA-expressing conjunctival fibroblasts from human ocular cicatricial pemphigoid            \u003ca rel=\"nofollow\"\u003e             PMID:                        26569118            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            NGF-induced tyrosine kinase independent TrkA signaling through CD44 is sufficient to maintain tumor aggressiveness in breast cancer            \u003ca rel=\"nofollow\"\u003e             PMID:                        25840418            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Urinary NGF, but not BDNF, levels decreased significantly after hyaluronic acid therapy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24614892            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915103273185,"sku":"BL-1793NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLSSAcFRNAACp9vJKOuQ209_68554ca0-87a2-4742-904d-d05959270569.jpg?v=1685853373"},{"product_id":"recombinant-human-gdf11-protein-bl-1835np","title":"Recombinant Human\/Mouse\/Rat GDF-11 Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human\/Mouse\/Rat Growth Differentiation Factor 11 is produced by our Mammalian expression system and the target gene encoding Asn299-Ser407 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eO95390\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGrowth\/differentiation factor 11; GDF-11; Bone morphogenetic protein 11; BMP-11\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGrowth\/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes.  The secreted signal acts globally to specify positional identity along the anterior\/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e12.5 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e13-20 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSupplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 50% glycerol, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eStore at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped on dry ice\/polar packs.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted signal that acts globally to regulate anterior\/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTGF-beta family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            4216           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            603936           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:10220           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000257868           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        30213293            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            Physical inactivity was significantly related to the decreased GDF11 levels in COPD.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29731621            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF11 expression was decreased in COPD patients' serum and cells when compared with that of healthy people.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29680737            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF11 may be a relevant myostatin-interacting peptide to successful aging in humans            \u003ca rel=\"nofollow\"\u003e             PMID:                        28701523            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN) in tissue specific aging.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28472635            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Tumor-suppressor inactivation of GDF11 occurs by precursor sequestration in triple-negative breast cancer            \u003ca rel=\"nofollow\"\u003e             PMID:                        29161592            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These studies identify distinctive structural features of GDF11 that enhance its potency, relative to GDF8; however, the biological consequences of these differences remain to be determined.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28257634            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In elderly Chinese women, osteoporosis risk was significantly increased with increases in GDF11 serum levels.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27557752            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble            \u003ca rel=\"nofollow\"\u003e             PMID:                        28715204            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            MSTN, but not GDF11, declines in healthy men throughout aging.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27304512            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF11 is highly concentrated in human platelets.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27509407            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The crystal structure of GDF11 was determined to a resolution of 1.50 A.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26919518            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues. It functions in the heart, skeletal muscle, and brain. Review.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27034275            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF11 inhibits rather than helps muscle regeneration.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26001423            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Show that there is no age-related cardiac hypertrophy in disease-free 24-month-old C57BL\/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26383970            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            in vitro sprout formation was increased as well by GDF11 treatment            \u003ca rel=\"nofollow\"\u003e             PMID:                        26026854            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Suggest GDF11 functions as encephalic regionalizing factor in neural differentiated mouse embryonic stem cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25352416            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF11 is a critical rheostat for bone turnover and a key integrator of bone homeostasis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25534870            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These data demonstrate GDF11 to be a master regulator of neural stem cell transcription that can suppress cell proliferation and migration by regulating the expression of numerous genes involved in both these processes            \u003ca rel=\"nofollow\"\u003e             PMID:                        24244313            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Expression of GDF11, a cytokine which blocks terminal erythroid maturation, was increased in erthyroblasts of thalassemic patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24658077            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Quantitative real-time reverse transcription-PCR in colorectal cancer specimens obtained from 130 patients showed that GDF11 mRNA expression in cancer tissue was significantly higher than in normal tissue            \u003ca rel=\"nofollow\"\u003e             PMID:                        17912435            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Members of the transforming growth factor beta (TGFbeta) superfamily, bone morphogenetic protein 2 (BMP2), and growth and differentiation factor 11 (GDF11), can signal cultured RGCs to form dendrites.            \u003ca rel=\"nofollow\"\u003e             PMID:                        17997109            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development.            \u003ca rel=\"nofollow\"\u003e             PMID:                        18519639            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin.            \u003ca rel=\"nofollow\"\u003e             PMID:                        18535106            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11.            \u003ca rel=\"nofollow\"\u003e             PMID:                        18596030            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Myostatin or 20 ng\/mL BMP-11 maintain the colony and cellular morphology of undifferentiated hESC, maintain POU5f1, NANOG, TRA-1-60, and SSEA4 expression, and display increased SMAD2\/3 phosphorylation            \u003ca rel=\"nofollow\"\u003e             PMID:                        19751112            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915101765857,"sku":"BL-1835NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLVuAbZRMAACcPwnSwmw477_82bae0a3-d0d6-43eb-9e55-d48d5fac8030.jpg?v=1685853313"},{"product_id":"recombinant-mouse-tgfb2-protein-bl-1912np","title":"Recombinant Mouse\/Rat TGF-beta 2 Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Mouse\/Rat Transforming Growth Factor Beta 2 is produced by our Mammalian expression system and the target gene encoding Ala303-Ser414 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003ca title=\"P27090\" target=\"_blank\" href=\"https:\/\/www.uniprot.org\/uniprotkb\/P27090\/entry\"\u003eP27090\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTGFB2; BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; MGC116892; Polyergin; TGF-beta2; TGF-beta-2; transforming growth factor beta-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTransforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e12.7 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e12 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 4mM HCl.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBiologically active. Please contact us to obtain bioactivity data.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg\/ml.Dissolve the lyophilized protein in 4mM HCl.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915099963617,"sku":"BL-1912NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLZOAKwT1AAB-h8XnjI0971_5980b85c-6c4f-42b6-a028-7d776fb04c1f.jpg?v=1685853235"},{"product_id":"recombinant-mouse-c3a-protein-bl-1937np","title":"Recombinant Mouse C3a Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Mouse Complement Component C3a  is produced by our E.coli expression system and the target gene encoding Ser671-Arg748 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP01027\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eComplement Component C3a; Anaphylatoxin; C3a\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eComplement is defined as key part of innate immunity and as the first line of defense in the fight against invading pathogens. Complement 3 (C3) is the most abundant component of the complement cascade and the convergent point for all three major complement activation pathways: namely classical, alternative and mannose-binding lectin pathways. Complement activation leads to the formation of the C3 convertase, which cleaves C3 into the key effector molecules, C3a (anaphylatoxin) and C3b (opsonin) which then drive microbe removal. By binding to C3a receptor (C3aR), C3a exhibits potent anaphylatoxin activity, including increased vascular permeability, triggering degranulation of mast cells, inflammation, and activating leukocytes.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e9.2 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e9 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eC3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.; Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. The short isoform has B-cell stimulatory activity.; Acts as a chemoattractant for neutrophils in chronic inflammation.; adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            mmu:12266           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            10090.ENSMUSP00000024988           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        28462915            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            Complement C3 role in the lung cancer progression.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29118090            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data report C3 as a novel myogenic factor secreted by undifferentiated preadipocyte that enhances myogenic differentiation of fetal progenitor cells and adult cells. The results show that complement C3 molecule internalizes myogenic and adipogenic precursor cells and then promotes their differentiation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28279023            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C3 deficiency can prolong MHC-II molecule mismatched skin allograft survival.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27641978            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C3 role in the retinal epithelium and photoreceptor degeneration            \u003ca rel=\"nofollow\"\u003e             PMID:                        28348233            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These findings shed light on mechanisms of age-related retinal alterations by identifying C3 as a potential therapeutic target for retinal aging.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28928904            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These findings suggest that C3 protects from early glaucomatous damage, a process that may involve EGFR signaling and other immune responses in the optic nerve head.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28446616            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            complement C3 or downstream complement activation fragments may play an important role in Abeta plaque pathology.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28566429            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C5 and C5aR have critical roles in the development of C3 glomerulopathy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28139294            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data show that months after irradiation (IR) complement component 3 (C3-\/-) mice made fewer errors than WT mice in a reversal learning test indicating better learning capacity in C3-\/- mice after IR.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27029069            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Study show s the regulation of C3 Activation by the Alternative Complement Pathway in the Mouse Retina            \u003ca rel=\"nofollow\"\u003e             PMID:                        27564415            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Time-lapse video microscopy established the localization of the complement anaphylatoxin C3a and its receptor on enteric neural crest cells during their migration in the embryonic gut.  C3a plays a role in regulating collective and directional cell migration, and in ganglia network organization during enteric nervous system ontogenesis. It regulates cell migration in a N-cadherin-dependent process.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27041467            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            nutrient sensing in the liver is coupled to release of C3 and potentially its metabolic and inflammatory functions.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27735945            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Retinal C3 was expressed by microglia\/macrophages located in the outer retina in AMD eyes. In rodent photo-oxidative damage, C3-expressing microglia\/macrophages and complement activation were located in regions of lesion expansion in the outer retina over 2 months            \u003ca rel=\"nofollow\"\u003e             PMID:                        28605809            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Wild-type C57BL\/6 mice with pristane-induced lupus developed a strong IFN signature, which was absent in immunoglobulin-deficient (muMT), C3(-\/-) , and CD18(-\/-) mice. In vivo phagocytosis of dead cells was impaired in C3-deficient mice.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27274010            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Study found that cancer-cell-derived C3 activates the C3a receptor in the choroid plexus epithelium to disrupt the blood-cerebrospinal fluid (CSF) barrier. This effect allows plasma components, including amphiregulin, and other mitogens to enter the CSF and promote cancer cell growth.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28283064            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            We induced anti-myeloperoxidase vasculitis in mice and confirmed a role for complement activation by demonstrating protection in C3-deficient mice.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27235854            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These data indicated that alpha7-nAChR caused the inhibition of ASPinduced activation of p38 kinase and NFkappa B to inhibit the production of MCP1 and keratinocytederived chemokine.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27572255            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results suggest that GAS utilizes diverse mechanisms to degrade C3b and thus to protect bacterial cells from the complement response of the host.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26945067            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study provideed the evidence that C3a plays a critical role in cerebral endothelial activation and leukocyte recruitment during inflammation in the brain.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26822321            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Demonstrate that cardiac Sirt1 plays an essential role in caloritc restriction-induced cardioprotection against myocardial I\/R injury by suppressing cardiac C3 expression.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26873964            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The roles of C3, CfB, and C3a receptor in the severity of S. aureus induced septic arthritis are reported.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26787717            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Study shows that C3a is locally produced by -retinal pigment epithelial cells suggesting a key role in early macular degenerations pathogenesis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26199322            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Complement C3 activation occurs following intramuscular islet transplantation, but it does not seem to affect the graft function.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26900812            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Studied whether increased levels of complement in HD brains contributed to disease progression in the R6\/2 mouse model of HD. Found C3 deficiency does not alter HD progression in the R6\/2 mouse model.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23097680            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Identify complement 5a as the major C3 activation product that was involved in macrophage polarization and DOCA-salt-induced vascular injury.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25573852            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            our findings define the mechanism of receptor crosstalk between CR3 and Dectin-1 and demonstrate the importance of their collaboration in host defense against fungal infection.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26132276            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Carboxypeptidase B2 deficiency reveals that complement C3a limits infection in a murine polymicrobial sepsis model.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25851247            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Complement component 3 is up-regulated via non-canonical TGF-beta signaling in the retinal pigment epithelium            \u003ca rel=\"nofollow\"\u003e             PMID:                        25802332            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data indicate that for all three pathways there was a strong correlation between the amount of Ccomplement C3 (C3) fragments and the reduction in functional complement activity.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25733354            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Therapeutic efficacy of radiotherapy depends on C3a and C5a.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25888260            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C3 secreted from mycoplasma-infected Mesenchymal stem cells (MSCs) has an important role in the immunomodulatory functions of MSCs.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24763049            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data indicate that absence of complement C3, complement C5 and Fc receptor subunit gamma (FcRgamma) does not impact autoantibody production in K\/BxN mice.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23237573            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results suggest that osteoclast-derived C3a functions in the relay from bone resorption to formation and may be a candidate for a coupling factor.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24470120            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Coagulation cascades, by generating thrombin and plasmin, respectively, provide C5 convertase activity, explaining why mobilization of hematopoietic stem cells in C3-deficient mice.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24667943            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results provide new insights into the role of systemic C3 in regulating contraction following intracellular bacterial infection and may help to develop vaccines that are more effective.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25187659            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            a role for outside-in iC3b-CD11b signals in limiting intrinsic organ inflammation            \u003ca rel=\"nofollow\"\u003e             PMID:                        24632830            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            have identified Complement C3 as a candidate plasma biomarker for measuring disease state in neuroblastoma            \u003ca rel=\"nofollow\"\u003e             PMID:                        24200836            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            A previously unknown function of C3a promotes protection to both myeloid and lymphoid cells against Listeria monocytogenes-induced apoptosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24981453            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24808362            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Loss of dopaminergic neurons was rescued by complement C3-deficient mice.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24948809            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Complement protein C3 exacerbates prion disease in a mouse model of chronic wasting disease.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24038599            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Complement C3 and C5 deficiency affects bone fracture healing.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24260573            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Radiation combined injury-induced alterations of corticosterone, CRP, C3, IgM, and PGE2 cause homeostatic imbalance and may contribute to reduced survival.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24175013            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data indicate that co-deficiency of factor H (FH) and MASP-1\/MASP-3 did not ameliorate either the plasma Complement C3 (C3) activation or glomerular C3 accumulation in FH-deficient mice.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24279761            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results of this study suggested that C3 plays a role in the regulation of the number and function of glutamatergic synapses in the hippocampus and exerts negative effects on hippocampus-dependent cognitive performance.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24378428            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C3 induces epithelial-to-mesenchymal transition and may be a primary factor to activate the renal renin-angiotensin systems to induce hypertension.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23926185            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data indicate complement C3 deposition on peanut extract (PE) was abolished in immunoglobulin- and C4-deficient sera.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23182714            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            ALI in H5N1-infected mice was caused by excessive complement activation, as demonstrated by deposition of C3, C5b-9, and MBL-C in lung tissue, and by up-regulation of MBL-associated serine protease-2 and the complement receptors C3aR and C5aR.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23526211            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            in vitro results suggest various metabolic hormones and inflammatory factors can affect acylation stimulating protein (ASP) production and that ASP could constitute a new link between adipocytes and macrophage            \u003ca rel=\"nofollow\"\u003e             PMID:                        23430572            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915020533985,"sku":"BL-1937NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLZyAYCfbAACsyeMfKak118_6f5acbfb-56c7-4851-818c-5836f353b4ba.jpg?v=1685850699"},{"product_id":"recombinant-human-c3a-protein-bl-1939np","title":"Recombinant Human C3a Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Complement Component C3a  is produced by our E.coli expression system and the target gene encoding Ser672-Arg748 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP01024\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eComplement Component C3a; C3a; Anaphylatoxin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eComplement is defined as key part of innate immunity and as the first line of defense in the fight against invading pathogens. Complement 3 (C3) is the most abundant component of the complement cascade and the convergent point for all three major complement activation pathways: namely classical, alternative and mannose-binding lectin pathways. Complement activation leads to the formation of the C3 convertase, which cleaves C3 into the key effector molecules, C3a (anaphylatoxin) and C3b (opsonin) which then drive microbe removal. By binding to C3a receptor (C3aR), C3a exhibits potent anaphylatoxin activity, including increased vascular permeability, triggering degranulation of mast cells, inflammation, and activating leukocytes.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e9.1 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e13 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eC3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.; Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.; Acts as a chemoattractant for neutrophils in chronic inflammation.; adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            1318           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            120700           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:718           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000245907           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        30139996            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            Clinical Manifestation of Patients With Atypical Hemolytic Uremic Syndrome With the C3 p.I1157T Variation in the Kinki Region of Japan.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29695177            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In our meta-analysis, C3 genetic polymorphisms unveiled a positive effect on the risk of advanced age-related macular degeneration, especially in Caucasians            \u003ca rel=\"nofollow\"\u003e             PMID:                        30352574            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Case Report: recurrent proliferative glomerulonephritis with persistent isolated C3 deposition.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29968411            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            A phage Ab against C3b that inhibited the alternative complement pathway, but not the classical pathway, was described in 2009. Studies using this Ab in a variety of assays have now demonstrated that it acts primarily by inhibiting tickover, thereby confirming that tickover really exists.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28855277            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Anti-HLA class I and class II C3d-binding donor-specific antibodies carried a twofold and 1.5-fold increased risk of kidney graft loss, respectively.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29265514            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Study shows no significant association of the C3 gene with uveitis, suggesting C3 confers either no or limited risk for uveitis susceptibility.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28408754            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Here we have shown for the first time, that ligand- or insulin-mediated activation of PPARgamma in human hepatoma cell line HepG2 causes the downregulation of C3 gene expression and protein secretion            \u003ca rel=\"nofollow\"\u003e             PMID:                        29550264            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Single Nucleotide Polymorphism rs11569514 in C3 and haplotypes of C3 variants were associated with schizophrenia in a Han Chinese population.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29742493            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            alphaXbeta2 uses the alphaX alphaI domain to bind iC3b on its C3c moiety at one of two sites.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28292891            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            findings revealed a significant association between variant p.R102G in complement component C3 gene with exudative age-related macular degeneration in the Tunisian population            \u003ca rel=\"nofollow\"\u003e             PMID:                        28470643            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            SNPs within the complement genes may contribute to IA, the first step to type 1 diabetes, with at least one SNP in C3 significantly associated with clinically diagnosed type 1 diabetes.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27306948            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            An increase in serum C4, as well as a decrease in C3, was an important outcome determinant for patients with immunoglobulin A nephropathy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28697742            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            rituximab was not effective in few cases of complement-mediated C3 glomerulonephritis and dense deposit disease . Despite promising results in immunoglobulin-associated and idiopathic Membranoproliferative glomerulonephritis, current evidence on this treatment remains weak, and controlled and prospective data are urgently needed.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28573137            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C3F polymorphism is associated with viral infections and protection from rejection after liver transplantation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27801525            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Pra1 targets C3 by cleaving C3 at a unique site. This inhibited effector function of the activation fragments. The newly formed C3a-like peptide lacked the C-terminal arginine residue needed for C3a-receptor binding and activation. Pra1 also bound to C3a and C3b generated by human convertases and blocked their effector functions, C3a binding to human C3a receptor, C3 antifungal activity, and C3b deposition.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28860090            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            data provide the first evidence that T17M rhodopsin mutant disrupts C3 secretion via the induction of ROS and the suppression of TWIST1.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28569420            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High C3 was significantly associated with incidence of diabetes after risk factor adjustments            \u003ca rel=\"nofollow\"\u003e             PMID:                        29029276            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study enclosed strong synergistic association of risk genotypes of C3 and CFH Y402H with AMD. We also revealed synergistic influence of CCL2-2518 and the at-risk genotype of the C3 in AMD with an estimated AP = 50.9% (adjusted AP = 24.7%). Present findings show that CCL2-2518 polymorphism is not an innocent bystander in AMD susceptibility when combined with the at-risk genotype of C3 (R102G).            \u003ca rel=\"nofollow\"\u003e             PMID:                        28095095            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our study shows C3 to be a relatively strong susceptibility gene for advanced-type-AMD (exudative-and-geographic-atrophy) in an Iranian population.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27029644            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BBB disruption is present in ACS, and elevated levels of IL-6 and C3 in CSF in diffuse NPSLE            \u003ca rel=\"nofollow\"\u003e             PMID:                        29036223            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            mobilizes dental pulp stem cells and specifically guides pulp fibroblast recruitment            \u003ca rel=\"nofollow\"\u003e             PMID:                        27497510            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study uncovers the origin of the effect of ionic strength on C3d-CR2 interaction and deepens the understanding of the molecular mechanism of their interaction, which is valuable for the design of vaccines and small molecule inhibitors.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27154286            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Studies indicate that the complement response lie the active fragments, C3a and C5a, acting through their specific receptors, C3aR, C5aR1 and C5aR2 to direct the cellular response to inflammation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28576324            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Plasma C3b levels are significantly increased in thrombotic microangiopathy patients after allogeneic stem cell transplantation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28801815            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Findings indicate that recognition of C3-opsonized Francisella tularensis, but not extensive cytosolic replication, plays an important role in regulating macrophage viability during intracellular infections with type A F. tularensis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28739830            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            exposure of neural stem cells to neutrophil-synthesized concentrations of C1q and C3a promoted astrogliogenesis and cell migrationtion.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28687659            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            THP appears to participate directly in complement inactivation by its ability to act as a cofactor for C3b degradation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28742158            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These data suggest that locally produced C3 is an important prosurvival mechanism in pancreatic beta-cells under a proinflammatory assault.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28582497            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            many types of human cells specifically internalized C3(H2O), the hydrolytic product of C3, and not native C3, from the extracellular milieu.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28192370            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Decreased C5a expression is associated with increased inflammation in cystic fibrosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28278205            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results show that expression of C3 was significantly increased in tumors from patients having a poor response to chemoradiation therapy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27254108            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C3d-positive glomerular staining is an independent risk factor for the development of end-stage renal disease in ANCA-associated renal vasculitis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27257040            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Factor I binds C3b-Factor H between Factor H domains 2 and 3 and a reoriented C3b C-terminal domain and docks onto the first scissile bond, while stabilizing its catalytic domain for proteolytic activity.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28671664            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The VEGF haplotype TGA could be used as a marker for poor visual prognosis in Tunisian patients with neovascular AMD treated with bevacizumab.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27116510            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C3 SNP rs2277984 may be a potential biomarker for predicting metabolic syndrome risk in patients receiving clozapine treatment.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26503818            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Strikingly C3, the central component of complement, plays a crucial role in the adherence of Brugia malayi to vascular endothelial cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28481947            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The uromodulin-CFH interaction enhanced the cofactor activity of CFH for factor I-mediated cleavage of C3b to inactivated C3b.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27113631            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Generated monoclonal antibody that can only bind to C3d when it manifests itself as the final end product of cleaved C3.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28174050            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C3 was strongly associated with insulin sensitivity after bariatric surgery.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28188738            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Study reveals structural differences and similarities between C3(H2O), its progenitor C3, and its functional analogue C3b. Data suggest that C3(H2O) generation is accompanied by the migration of the thioester-containing domain of C3 from one end of the molecule to the other.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27250206            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            human neutrophil peptides 1-3 and complement activation fragments iC3b were higher in patients with acute thrombotic thrombocytopenic purpura - indicating a role of innate immunity in acute autoimmune TTP.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27662014            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The data suggest a common evolutionary origin for both inhibitory mechanisms, called decay acceleration and cofactor activity, with variable C3b binding through domains at sites ii, iii, and iv, and provide a framework for understanding regulators of complement activation (RCA) disease-related mutations and immune evasion.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27013439            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CFH, ARMS2, and C3 were associated with specific features of neovascularization at the time patients were enrolled in Comparison of Age-Related Macular Degeneration Treatments Trials .            \u003ca rel=\"nofollow\"\u003e             PMID:                        27099955            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Elevated C3a is able to predict the mortality following cardiac resynchronization therapy of heart failure            \u003ca rel=\"nofollow\"\u003e             PMID:                        27492980            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Decreased serum C3 may have a role in renal pathology classification for patients with silent but not with overt lupus nephritis            \u003ca rel=\"nofollow\"\u003e             PMID:                        27900491            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Decreased transcription of C3R mRNA was found in patients with Type 2 Diabetes as compared to non-diabetics.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27291248            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            analyzed C5 c.2654G\u0026gt;A and C3 gene polymorphism in 220 Chinese patients            \u003ca rel=\"nofollow\"\u003e             PMID:                        27307199            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            this paper shows that chymase may control C3-related pathology in cutaneous vasculitis            \u003ca rel=\"nofollow\"\u003e             PMID:                        27465068            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Case Report: severe active C3 glomerulonephritis triggered by immune complexes treated with eculizumab.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27717365            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915027513569,"sku":"BL-1939NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLZ2AbZZRAACxbqN9gzo564_42908b46-4af5-4ddc-8e93-41cc34bcfcc9.jpg?v=1685850862"},{"product_id":"recombinant-human-cfd-protein-his-tag-bl-1943np","title":"Recombinant Human CFD Protein (C-10His)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Complement Factor D is produced by our Mammalian expression system and the target gene encoding Ile26-Ala253 is expressed with a 10His tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003ca title=\"P00746\" target=\"_blank\" href=\"https:\/\/www.uniprot.org\/uniprotkb\/P00746\/entry\"\u003eP00746\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eComplement factor D; CFD; Adipsin; C3 convertase activator; Properdin factor D; DF; PFD\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eComplement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3, which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the regulation of systemic energy balance and physiologic and pathologic processes, including immunity and inflammation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e25.8 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e28 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSupplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 2mM CaCl2, 5% Trehalose, 50% Glycerol, pH 8.5.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eStore at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening.  Please minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped on dry ice\/polar packs. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915036295393,"sku":"BL-1943NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLZ6AFYdpAAC4TiacrfU645_a094cce9-da66-4218-8381-7b21ac8b133f.jpg?v=1685851115"},{"product_id":"recombinant-human-gdf5-protein-bl-1968np","title":"Recombinant Human GDF-5 Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Growth\/Differentiation Factor 5 is produced by our E.coli expression system and the target gene encoding Ala382-Arg501 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP43026\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGrowth\/differentiation factor 5; GDF-5; Bone morphogenetic protein 14; BMP-14; Cartilage-derived morphogenetic protein 1; CDMP-1; Lipopolysaccharide-associated protein 4; LAP-4; LPS-associated protein 4; Radotermin; CDMP1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGrowth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-IIor Activin RII) serine\/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins (Smad1, 5, and 8). GDF-5 is involved in multiple developmental processes including limb generation, cartilage development, joint formation, bone morphogenesis, cell survival, and neuritogenesis. Inhibition of GDF-5 expression or alteration of its signaling can facilitate the development of osteoarthritis.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e13.7 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e15 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 4mM HCl.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg\/ml.Dissolve the lyophilized protein in 4mM HCl.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGrowth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1\/5\/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted. Cell membrane.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTGF-beta family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            4220           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            112600           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:8200           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000363489           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        30044130            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            study shows that there exists a relationship between GDF5 (SNP rs143383) and Developmental dysplasia of the hip (DDH) in our population. Second, we found for the first time that the genotype TT and the T allele were overly expressed in the patients and the fathers. More studies on the confirmation of this genetic marker for DDH are called for.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29797005            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Two Pakistani families with sequence variants in GDF5 and TRPS1 causing brachydactyly type C and tricho-rhino-phalangeal syndrome type III are described.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29436063            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The dysfunctional gene GDF5 was successfully corrected in adipose tissue-derived mesenchymal stem cells using a pair of transcription activatorlike effector nucleases.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29393424            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            No association has been found between GDF5 +104 T\/C promoter polymorphism and osteoarthritis in the Eastern Turkey population.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28886316            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results of the current study revealed that SNP rs143383 of GDF5 is a compelling risk factor for knee OA [Osteoarthritis] and that GDF5 has an etiological effect on the development of OA [Osteoarthritis].            \u003ca rel=\"nofollow\"\u003e             PMID:                        29056119            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            A Study of IL-1beta, MMP-3, TGF-beta1, and GDF5 Polymorphisms and Their Association with Primary Frozen Shoulder in a Chinese Han Population            \u003ca rel=\"nofollow\"\u003e             PMID:                        28676856            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BMP-14 rs143383 polymorphism reduced the susceptibility to knee osteoarthritis (OA) and hand OA not only in total analysis but also in subgroup analysis; BMP-14 rs143383 polymorphism may be a protective factor against OA occurrence            \u003ca rel=\"nofollow\"\u003e             PMID:                        29049177            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The structure of Grem2-GDF5 complex has revealed a number of key findings for DAN-family mediated BMP2 inhibition.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27524626            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            miR-615-3p negatively regulates the osteogenic differentiation of hLF cells through post-transcriptionally suppressing osteogenic regulators GDF5 and FOXO1.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28460412            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            p38, c-jun, and NFkappaB pathways activated during intervertebral disc degeneration by IL-1beta but not GDF-5            \u003ca rel=\"nofollow\"\u003e             PMID:                        27391542            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF5 elicited significant (p \u0026lt; 0.05) changes in the expression of anabolic, catabolic and hypertrophic genes with several consistent effects in healthy donors and in OA patients            \u003ca rel=\"nofollow\"\u003e             PMID:                        28481944            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF5 was up regulated in patients after chronic rhinosinusitis developing osteitis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27888647            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Titanium (Ti) surface modification with the combination of hBMP-2 and hGDF-5 for the two growth factor-coated Ti implants can improve the clinical properties of implants for orthopedic and dental applications.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28124978            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            he large array of modular enhancers for Gdf5 provide a new foundation for studying the spatial specificity of joint patterning in vertebrates, as well as new candidates for regulatory regions that may also influence osteoarthritis risk in human population            \u003ca rel=\"nofollow\"\u003e             PMID:                        27902701            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The purpose of this study is to investigate the immunohistochemical expression of cytokeratin 18 (CK18) and the reactivity to GDF5 (CDMP-1), called the morphogenetic protein-1, cartilage-derived, in lingual squamous cell carcinoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27151703            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            homozygous sequence variants in the GDF5 gene underlie acromesomelic dysplasia type-grebe in consanguineous families            \u003ca rel=\"nofollow\"\u003e             PMID:                        27577507            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The prevention of IL-1Beta-induced nucleus pulposus extracellular matrix degeneration by miR-7 silencing was attenuated by GDF5 siRNA.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27583982            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Mutations in three genes (GDF5, NPR2, BMPR1B) have been reported to cause different forms of acromesomelic dysplasia            \u003ca rel=\"nofollow\"\u003e             PMID:                        26926249            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            we demonstrate that the transforming growth factor-beta1 and the growth differentiation factor 5 synergistically drive the nucleopulpogenic differentiation process. The commitment of the hASCs was robust and highly specific as attested by the expression of NP-related genes characteristic of young healthy human NP cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        26661057            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The data suggest that Ad-GDF-5 gene therapy is a potential treatment for IDD, which restores the functions of degenerative intervertebral disc through enhancing the ECM production of human NP cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26739524            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            An association of SNP in GDF5 with temporomandibular joint osteoarthritis in female Han Chinese.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25757091            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            results demonstrate that SNP rs143383 of GDF5 is a compelling risk factor for both knee and hand osteoarthritis (OA) and provide further support for GDF5 in the etiology of OA [meta-analysis]            \u003ca rel=\"nofollow\"\u003e             PMID:                        25894512            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Two novel homozygous missense mutations in the GDF5 gene cause brachydactyly type C.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25820810            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            our results showed that GDF-5 and BMPRII expressed both in normal and degenerated intervertebral disc tissues, and GDF-5 might have an inhibition effect on degenerated lumbar intervertebral discs            \u003ca rel=\"nofollow\"\u003e             PMID:                        25755766            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This meta-analysis finds that the C allele and CC genotype of the GDF5 gene are protective for knee osteoarthritis susceptibility.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25467786            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our results revealed that the GDF5 SNP was associated with susceptibility to the meniscus injury and postoperative function recovery in Chinese male soldiers.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24227118            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            missense mutations p.T201P and p.L263P interfere with the protein structure and thereby reduce the amount of fully processed, biologically active GDF5, finally causing the clinical loss of function phenotype.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25092592            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The proregion is stabilized by an intramolecular disulfide bond. The isolated proregion folds independently of the mature domain.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25174448            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Growth differentiation factor 5 and canonical Wnt signaling may contribute to molecular mechanisms of osteoarthritis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24561281            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results suggest that obesity leads to upregulation of GDF5 expression responsible for the promotion of brown adipogenesis through a mechanism relevant to activation of the NF-kappaB pathway.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25223801            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            results suggested that GDF5 polymorphism is associated with susceptibility to symptomatic lumbar disc herniation in Chinese Han population and type II collagen in the nucleus pulposus may be a factor in susceptibility to symptomatic lumbar disc herniation            \u003ca rel=\"nofollow\"\u003e             PMID:                        24105021            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Osteoarthritis chondrocytes do not respond in a predictable manner to culture with exogenous GDF5.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24466161            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High GDF5 expression is associated with osteoarthritis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24861163            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The expression of growth differentiation factor 5 (GDF5) and aggrecan in 15 cases of salivary gland pleomorphic adenomas, was investigated.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24398992            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            established an association between two SNPs (rs224332 and rs224333) of GDF5 and DDH development in a female Chinese population.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24114442            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In vitro findings suggest that the degenerating disc milieu, with high proinflammatory cytokine levels, may limit expression of GDF-5, resulting in limited regenerative capacity of the intact disc.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24582800            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These novel insights into the biology of GDF5 might also provide further clues on the pathophysiology of OA.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24098149            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The novel missense mutation p.Leu176Pro causes impaired secretion of GDF5 in Brachydactyly type C and mild Grebe type chondrodyslplasia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23812741            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF5 is the only osteoarthritis susceptibility gene so far identified with definite evidence.[Review]            \u003ca rel=\"nofollow\"\u003e             PMID:                        24003854            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Overall, a statistically significant association was found between the +104T\/C polymorphism of GDF5 and risk of knee osteoarthritis            \u003ca rel=\"nofollow\"\u003e             PMID:                        23151597            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF5 harbors a C\/A transversion located -41 bp relative to the transcription start site that leads to increased gene expression.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22929025            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF5 polymorphisms are associated with susceptibility to low back pain during military training in Chinese soldiers.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23725396            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In conclusion, the rs143383 variant was not found to associate with the risk of ACL rupture.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23090674            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            we have identified four trans-acting factors that are binding to GDF5, three of which are modulating GDF5 expression via the OA susceptibility locus rs143383.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23825960            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Although the effect size of the association between OA and GDF5 is small, there is suggestive evidence for an association.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23423687            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF5 regulates TGF-beta-dependent angiogenesis in breast carcinoma cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23226264            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Growth differentiation factor 5 modulation of chondrogenesis of self-assembled constructs involves gap junction-mediated intercellular communication.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23121099            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            analysis of positive selection on the osteoarthritis-risk and decreased-height associated variants at the GDF5 gene in East Asians            \u003ca rel=\"nofollow\"\u003e             PMID:                        22905146            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our findings in 5 population cohorts from Northern Europe indicate that a variant in the GDF5 gene is a risk factor for lumbar disc degeneration in women.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21360499            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915103863009,"sku":"BL-1968NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLaSAUYkUAAC0eDTeA9o589_72de51d5-4611-4287-8128-ccfd826e896b.jpg?v=1685853393"},{"product_id":"recombinant-human-complement-component-c5a-c5a-protein-bl-1971np","title":"Recombinant Human C5a Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human C5a is produced by our E.coli expression system and the target gene encoding Thr678-Arg751 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP01031\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eComplement C5; C5a anaphylatoxin; C5a\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eHuman Complement 5a (C5a) is an enzymatically generated glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. C5a is a 74 amino acid (aa) peptide that is created by the activity of C5a convertase on the C5 α-chain. Human C5a has four α-helices plus three intrachain disulfide bonds that create a triple loop structure. Human C5a is 60% and 54% aa identical to mouse and rat C5a, respectively. C5a binds to a signaling G-protein coupled receptor (C5aR\/CD88) and a nonsignaling GPCR termed C5L2. Activation of Cd88 results in neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils, and induces release of histamine in basophils and mast cells.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e8.4 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e12 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eActivation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.; Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            1331           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            120900           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:727           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000223642           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        29885865            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            recombinant C5a potentiated TNFalpha-induced NF-kappaB activation in renal tubular epithelial cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        29031143            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            tumoral C5a is an independent adverse prognostic biomarker for clinical outcome of Clear Cell Renal Cell Carcinoma patients after nephectomy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27381421            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C5a synergises with P. aeruginosa LPS in both PD-L1 expression and the production of IL-10 and TGF-beta.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27624143            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these results not only confirm the critical role of C5b-9 in complement-mediated hemolysis and but also highlight the critical role of C5b-9 in inflammasome activation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27444648            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Mean cerebrospinal fluid C5 levels increased in patients with depression and schizophrenia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29454970            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            elevated in the cerebrospinal fluid of preterm newborns            \u003ca rel=\"nofollow\"\u003e             PMID:                        27806664            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Up-regulation of granulocyte and monocyte CD11b during plasma separation was C5-dependent.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29575196            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study provides the preclinical rationale for the combined blockade of PD-1\/PD-L1 and C5a to restore antitumor immune responses, inhibit tumor cell growth, and improve outcomes of patients with lung cancer            \u003ca rel=\"nofollow\"\u003e             PMID:                        28288993            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Diagnosis and therapeutic management of neonatal hemochromatosis cannot only be based on C5b9 expression in liver samples as it is not specific of this disease.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28085791            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C5a-C5aR enriched clear cell renal cell carcinoma patients significantly had a poorer overall survival and recurrence free survival after nephrectomy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27821813            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C5a\/C5aR pathway promotes gastric cancer pathogenesis by suppressing p21\/p-p21 expression via activation of PI3K\/AKT signaling.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29031586            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            this study shows that C5 acts in the control of serum triglycerides and cholesterol, liver cholesterol deposition, liver homeostasis and C5 promotes a pro-inflammatory liver environment in our mouse model of alcoholic liver disease            \u003ca rel=\"nofollow\"\u003e             PMID:                        26896155            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            a library of 61 peptides based on the C-terminus of C5a was assayed for the ability to selectively modulate C5aR2 function.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27108698            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data show the expression of a neoepitope which was exposed on complement C5 (C5) after binding to eculizumab in vivo.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28610663            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Plasma levels of sC5b-9 were significantly increased in patients with thrombotic microangiopathy after allogeneic stem cell transplantation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28801815            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C5 gene analysis revealed two novel mutations as causative of C5 deficiency in 3 north African families            \u003ca rel=\"nofollow\"\u003e             PMID:                        27026170            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            data indicate that properdin enhances platelet\/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation            \u003ca rel=\"nofollow\"\u003e             PMID:                        27183616            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            this study shows that complement C5a-induced changes in neutrophil morphology during inflammation            \u003ca rel=\"nofollow\"\u003e             PMID:                        28671713            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Increased C5a expression is associated with increased inflammation in cystic fibrosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28278205            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our results provide evidence that an intrinsic C5a generation may not be fully blocked by eculizumab in various disease settings. Controlling and fully blocking C5a induced signaling in humans therefore warrants a targeted approach            \u003ca rel=\"nofollow\"\u003e             PMID:                        28366510            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These findings, together with data from genomic variation databases, indicate a 0.5-2% prevalence of the Complement factor 5 (C5) p.A252T mutation in heterozygosity in sub-Saharan Africa. Therefore, this mutation may have a relevant role in meningococcal disease susceptibility in this geographical area.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28369827            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            we found the GG variant contributing to the risk of LAA-subtype ischemic stroke but were unable to find an association between ischemic stroke functional outcome at 90 days and C5 rs17611 variants.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27901252            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            this study shows that C5a signaling induces apoptosis in brain vascular endothelial cells in experimental lupus            \u003ca rel=\"nofollow\"\u003e             PMID:                        27213693            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            We determined the genotypes of five polymorphisms (rs12237774, rs17611, rs4837805, rs7026551, and rs1017119) of C5 gene. In univariate analysis, rs17611 was significantly associated with Ischemic Stroke (IS) in the additive model, the dominant model, and recessive model. In this sample of patients, genetic variation of rs17611 in C5 is associated with higher prevalence of IS.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27768391            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the complement anaphylatoxin C5a shows an inverse correlation with platelet bound oxLDL. The relationship of oxidized lipids to particular complement components may add to the platelet-lipid interplay in atherogenesis and trigger future clinical and mechanistic studies.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27025272            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In an arterial thrombosis model, plasminogen activator administration increased C5a levels. Overall, these findings suggest plasmin bridges thrombosis and the immune response by liberating C5a and inducing MAC assembly.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27077125            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C5 rs2269067 GG genotype confers risk for proliferative diabetic retinopathy of type 2 diabetes in Chinese Han population (associated with an elevated C5 mRNA expression and an increased IL-6 production)            \u003ca rel=\"nofollow\"\u003e             PMID:                        26934706            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C5a can induce the expression of TLR4 in retinal pigment epithelial cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26487798            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            elevated in the inflammatory lesions of placentas with villitis of unknown etiology            \u003ca rel=\"nofollow\"\u003e             PMID:                        25725937            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results identify complement activation product C5a as a priming signal for RPE cells that allows for subsequent inflammasome activation by stimuli such as lipofuscin-mediated photooxidative damage.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26565031            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            a significant up-regulation (173 fold increase, p \u0026lt; 0.0001) in the expression of inflammatory complement component 5 (C5) in endometriosis was detected for the first time.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24316322            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25735751            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            complement C5a signaling supports human stem cell pluripotency and survival, and thus may play a key role in shaping early human embryonic development            \u003ca rel=\"nofollow\"\u003e             PMID:                        25132103            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Rs2900180 in C5-TRAF1 and linked variants in a 66Kb region were associated with radiographic progression in ACPA-negative RA            \u003ca rel=\"nofollow\"\u003e             PMID:                        25566937            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The C5 rs2269067 GG genotype confers risk for AAU in a Chinese population and is associated with an elevated C5 serum concentration and an increased IL-17 production.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26230759            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TRAF1\/C5 rs10818488 polymorphism is not a genetic risk factor for acquired aplastic anemia in a Chinese population.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25500258            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study shows that individuals homozygously expressing the rheumatoid arthritis risk s17611 allele exhibit increased C5a and decreased C5 in plasma, evidence of increased C5 turnover.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25725109            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Elevated sC5b-9 levels are indicative of active disease in atypical hemolytic uremic syndrome.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25818678            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In conclusion, the present study indicates that C5a may promote the proliferation of breast cancer cells through Akt1 activation of the RGC-32 gene.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25230890            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C5A is released from C5 by a cancer cell membrane bound serine protease which enchances neoplasm invasiveness, immune evasion, and neovascularization.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25050844            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The interaction between S1P and C5a plays an important role in neutrophils for antineutrophil cytoplasmic antibody -mediated activation            \u003ca rel=\"nofollow\"\u003e             PMID:                        25000985            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our data provide new insights into the regulatory role of C5a in PMN function during systemic C. albicans infection in human blood and identify C5a as an essential mediator of PMN activation in response to C. albicans.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25539819            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This report includes seven affected families indicating that C5 deficiency is not rare in South Africa.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25534848            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study reveals that the C5 complement protein may play a critical role in mediating white matter injury through inflammation in the setting of chronic cerebral hypoperfusion.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24386419            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the role of C5a as an endogenous priming signal that is required for the initiation of uric acid crystal-induced IL-1beta production.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25229885            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Spontaneous abortion is associated with elevated systemic C5a and reduced mRNA of complement inhibitory proteins in placenta.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24802103            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            C5a, but not C5a-des Arg, was able to induce further heteromer formation between complement C5a receptors.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24060963            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data indicate that cholesterol crystals (CC) employed C5a in the release of IL-1beta.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24554772            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Serum level of initiating complement factor (C1q) but not complement regulator C5 is deficient in schizophrenic patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23235303            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915020435681,"sku":"BL-1971NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLaWARJHJAAC2gAAlOM8237_9cb29e9a-3b87-44c5-bd9f-81f428b7fda1.jpg?v=1685850698"},{"product_id":"recombinant-mouse-baffr-protein-fc-tag-bl-2199np","title":"Recombinant Mouse BAFFR Protein (C-Fc)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 13C is produced by our Mammalian expression system and the target gene encoding Ser10-Ala 71 is expressed with a human IgG1 Fc tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003ca title=\"Q9D8D0\" target=\"_blank\" href=\"https:\/\/www.uniprot.org\/uniprotkb\/Q9D8D0\/entry\"\u003eQ9D8D0\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBAFF R; BAFFR; BR3; CD268; TNFRSF13C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA\/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI\/TNFRSF13B) and BAFF receptor (BAFF R\/BR3\/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, in resting CD4+ T cells, in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells. Similarly, A\/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells, suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. It has been proposed that abnormally high levels of BAFFR\/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e33.8 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e40-55 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915063558369,"sku":"BL-2199NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLQ2AUSKRAACLdn6X1S8144_a0942b7d-9657-4c6b-bc40-b895569111a8.jpg?v=1685851983"},{"product_id":"recombinant-human-baff-protein-his-tag-bl-2200np","title":"Recombinant Human BAFF Protein (N-6His)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human TNF Ligand Superfamily Member 13B is produced by our Mammalian expression system and the target gene encoding Ala134-Leu285 is expressed with a 6His tag at the N-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eQ9Y275\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTNFSF13B\/TNFSF20 belongs to the tumor necrosis factor family. It abundantly is expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. Cytokine that binds to TNFRSF13B\/TACI and TNFRSF17\/BCMA. TNFSF13\/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR\/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3 acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG\/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors. Mature human BAFF consists of a 46 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 218 aa extracellular domain (ECD) with a stalk region and one TNF-like domain. Within aa 134-285 of the ECD, human BAFF shares 72% aa sequence identity with mouse BAFF.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e19.3 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e22 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBiologically active. Please contact us to obtain bioactivity data.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eCytokine that binds to TNFRSF13B\/TACI and TNFRSF17\/BCMA. TNFSF13\/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR\/BR3) promotes the survival of mature B-cells and the B-cell response.; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.; Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG\/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eCell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 13b, soluble form]: Secreted.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTumor necrosis factor family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            11929           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            603969           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:10673           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000365048           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        29572442            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            analysis of how BAFF is neutralized by belimumab gives insight into treatment of systemic lupus erythematosus            \u003ca rel=\"nofollow\"\u003e             PMID:                        29572471            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Study uncovers a previously unrecognized regulation of BAFF by testosterone and raises important questions about BAFF in testosterone-mediated protection against autoimmunity. Among healthy men, serum BAFF levels are higher in men with low testosterone.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29802242            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High BAFF expression is associated with systemic lupus erythematosus.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28992184            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Co-immunoprecipitation analysis and siRNA-mediated suppression of CREB expression indicated that phospho-CREB has a positive effect on pro-inflammatory gene expression in the crosstalk between BAFF- and TLR4-mediated signaling by forming trimeric complexes containing NF-kappaB, CBP, and CREB            \u003ca rel=\"nofollow\"\u003e             PMID:                        28374824            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            this study shows that BAFF augments IgA2 and IL-10 production by TLR7\/8 stimulated total peripheral blood B cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        28921509            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            elevated pretransplant serum BAFF levels negatively affect renal allograft survival and represent a risk factor for allosensitization and subsequent antibody-mediated rejection            \u003ca rel=\"nofollow\"\u003e             PMID:                        29277566            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Increased BAFF expression is associated with B cell class switching in patients with tuberculous pleural effusion.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29845274            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Expression patterns of BAFF and its receptors differ according to lupus nephritis class.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29087261            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Serum BAFF levels are elevated in idiopathic inflammatory myositis, more so in children.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29516280            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Post-transplant antibody mediated rejection in kidney transplantation recipients can be predicted by perioperative elevations in serum BAFF level.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27888573            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results of the present study revealed a correlation between BAFF and the PI3K\/Akt\/mTOR signaling pathway, and it is hypothesized that they are involved in the pathogenesis of lupus nephritis            \u003ca rel=\"nofollow\"\u003e             PMID:                        28849060            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results suggest that increased levels of BAFF and APRIL produced in the central nervous system may influence the development of anti-neutrophil cytoplasmic antibody-hypertrophic pachymeningitis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28847534            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Blood B lymphocyte stimulator (BLyS)\/BAFF levels of HIV-uninfected commercial sex workers (CSWs) were lower than those observed in both HIV-infected CSW and HIV-uninfected non-CSW groups.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27561453            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            our study throws light on the crosstalk between BAFF and BCR signaling pathways in neoplastic B cells, and provides insights into the mechanistic effects of SYK inhibitors in CLL.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28838991            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            genetic polymorphisms of BAFF may increase the risk of posttransplant development of donor specific antibodies in kidney allograft recipients            \u003ca rel=\"nofollow\"\u003e             PMID:                        28624489            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            P\\pre-sensitized patients had significantly higher BAFF levels before transplantation and suffered significantly more often from early steroid-resistant, mainly antibody-mediated rejections            \u003ca rel=\"nofollow\"\u003e             PMID:                        28867309            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Elevated blood BAFF levels could be associated with a more stable disease.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27383531            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF rs9514828 polymorphism may be associated with the chronic hepatitis and the combinatorial action of rs9514828 and rs12583006 may confer susceptibility to chronic HBV infection and the resolution of the infection, suggesting that host genetic factors associated with B cell mediated immune responses are involved in chronic HBV infection.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28627389            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study demonstrated that An Increase of Cerebrospinal Fluid B-cell Activating Factor Level in Pediatric Patients With Acute Viral Encephalitis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28259511            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            data show that BAFF levels at the time of cGvHD diagnosis are associated with non-relapse-mortality, and also are potentially useful for risk stratification.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28481353            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF-R was consistently expressed on B cells infected by HCMV. Enhancement of BAFF\/BAFF-R signaling decreased the apoptosis rate and extended the survival of B cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28442365            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            soluble BCMA sequesters circulating BAFF, thereby preventing it from performing its signaling to stimulate normal B-cell and plasma cell development, resulting in reduced polyclonal antibody levels in multiple myeloma patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26960399            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            up-regulated expression in intractable temporal lobe epilepsy            \u003ca rel=\"nofollow\"\u003e             PMID:                        28441631            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            results showed that serum BAFF in nasal type, extranodal NK\/T cell lymphoma patients was significantly higher than that in control group and negatively correlated with patients' survival.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27668971            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF has a role in inducing IL35 production by regulatory B cells in lupus            \u003ca rel=\"nofollow\"\u003e             PMID:                        28844943            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Inhibition of ADAM10 augments BAFF-dependent survival of primary human B cells, whereas inhibition of ADAM17 increases BAFFR expression levels            \u003ca rel=\"nofollow\"\u003e             PMID:                        28249164            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data presented show that B-cell activating factor (BAFF) plays a central role in the induction and maintenance of cigarette smoke-induced pulmonary antinuclear antibodies and suggest a therapeutic potential for BAFF blockade in limiting autoimmune processes associated with smoking.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28039405            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA) do not change            \u003ca rel=\"nofollow\"\u003e             PMID:                        28834574            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The BAFF promoter increased in response to TNF-alpha treatment or overexpression of HIF-1alpha. However, TNF-alpha-induced BAFF expression and promoter activity decreased after treatment with the ERK inhibitor PD98059.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28383556            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study indicates that orbital fibroblasts from Graves' orbitopathy can express BAFF and mediate the intraorbital survival of B cells via BAFF mechanism.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28087387            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Rapamycin attenuates excessive hsBAFF-induced cell proliferation\/survival via blocking mTORC1\/2 signaling in normal and neoplastic B-lymphoid cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28300280            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Inhibition of B cell plasmablast differentiation by reduction of Aiolos and Ikaros may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF and Aiolos may prime CD27(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF and proinflammatory cytokines.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28848067            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BCMA has other contributors for ligands binding except DxL motif. The affinity of BCMA for APRIL higher than for BAFF may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future            \u003ca rel=\"nofollow\"\u003e             PMID:                        28260502            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            study demonstrated a high prevalence of endogenous antibodies to BAFF in a multi-ethnic Asian systemic lupus erythematosus (SLE) cohort; while levels of serum BAFF correlated positively with disease activity, levels of anti-BAFF antibody were correlated negatively with levels of its target cytokine, anti-dsDNA antibody and clinical disease activity            \u003ca rel=\"nofollow\"\u003e             PMID:                        28388832            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            this study provides new useful information about the increased levels of BAFF observed during HIV-1 infection and highlights the importance of macrophages as a source of BAFF            \u003ca rel=\"nofollow\"\u003e             PMID:                        27022194            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The novel association between BAFF and inflammatory bowel disease (IBD) seems to identify that BAFF might regulate the inflammatory process in these diseases and it appears to be a potential marker of IBD.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27056038            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In BAFF, rs2893321 may be a susceptible genetic variant for the development of GD and AITDs. Associations of rs2893321 with susceptibility to GD and AITDs and the correlation between rs2893321 and TAb exhibit a dimorphic pattern. Additional studies with larger sample sizes are required to confirm our findings.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27136204            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF and IL-17A are associated with different subphenotypes of primary Sjogren's syndrome.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25941062            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The expression levels of serum BAFF and the three receptors (TACI, BCMA and BAFF-R) in non-Hodgkin lymphoma patients were significantly higher than in healthy controls.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28028945            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Plasma BAFF levels were positively associated with serum creatinine, proteinuria, uric acid and group A Streptococcus infection index in patients with IgA nephropathy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28260100            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            this study shows that chicoric acid suppresses BAFF expression by inhibiting NF-kappaB activity, and chicoric acid may serve as a novel therapeutic agent to down-regulate excessive BAFF expression in autoimmune diseases            \u003ca rel=\"nofollow\"\u003e             PMID:                        28122293            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Findings indicate that BAFF expression is significantly increased in chronic rhinosinusitis with nasal polyps patients and may orchestrate inflammatory load in polyp tissues by regulating T and B cell-mediated response.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28035475            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Urinary APRIL (uAPRIL) and BAFF (uBAFF) levels were raised significantly in AN.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27804111            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF levels are lower in patients with antibody-mediated kidney rejection and also in patients with concurrent humoral and cellular rejection compared with patients without rejection            \u003ca rel=\"nofollow\"\u003e             PMID:                        28083608            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The BLyS level is increased in some lupus patients. There was a moderate correlation with titers of anti-DNA antibody and disease activity.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27100979            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In Sjogren's syndrome (SS) patients, EULAR Sjogren's syndrome disease activity index (ESSDAI) is negatively associated with serum levels of 25(OH)-D3 and positively associated with BAFF.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28074193            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results suggest that miR-202 functions as a modulator that can negatively regulate BAFF by inhibiting multiple myeloma tumor cell survival, growth, and adhesion in the bone marrow microenvironment.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25971527            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Variants in BAFF gene is associated with chronic lymphocytic leukemia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27468724            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results demonstrated that BAFF has an important role in the pathogenesis of newly diagnosed childhood immune thrombocytopenia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24911453            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915023122657,"sku":"BL-2200NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLQ2AKHj-AACR7K4TuXE433_8a803983-4d95-4c9a-a726-358b778759c8.jpg?v=1685850768"},{"product_id":"recombinant-human-baffr-protein-fc-tag-bl-2228np","title":"Recombinant Human BAFFR Protein (C-Fc)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Tumor Necrosis Factor Receptor Superfamily Member 13C is produced by our Mammalian expression system and the target gene encoding Ser7-Ala71 is expressed with a human IgG1 Fc tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eQ96RJ3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBAFF R; BAFFR; BR3; CD268; TNFRSF13C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA\/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI\/TNFRSF13B) and BAFF receptor (BAFF R\/BR3\/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, in resting CD4+ T cells, in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells. Similarly, A\/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells, suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. It has been proposed that abnormally high levels of BAFFR\/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e33.4 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e38-58 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBiologically active. Please contact us to obtain bioactivity data.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eB-cell receptor specific for TNFSF13B\/TALL1\/BAFF\/BLyS. Promotes the survival of mature B-cells and the B-cell response.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eMembrane; Single-pass type III membrane protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            17755           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            606269           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:115650           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000291232           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        27436754            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            Expression patterns of BAFF and its receptor BAFF-R differ according to lupus nephritis class.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29087261            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            up-regulated expression in intractable temporal lobe epilepsy            \u003ca rel=\"nofollow\"\u003e             PMID:                        28441631            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Inhibition of ADAM10 augments BAFF-dependent survival of primary human B cells, whereas inhibition of ADAM17 increases BAFFR expression levels.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28249164            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Relationships between serum BAFF and BBR expression [(BAFFR, calcium signal modulating cyclophilic ligand interactor (TACI) and B cell maturation antigen (BCMA)] were determined on B cell subsets, defined using immunoglobulin (Ig)D\/CD38. Twenty pre-RTX and 18 rheumatoid arthritis patients relapsing after B cell depletion were included.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28800164            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA) do not change            \u003ca rel=\"nofollow\"\u003e             PMID:                        28834574            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The expression levels of serum BAFF and the three receptors (TACI, BCMA and BAFF-R) in non-Hodgkin lymphoma patients were significantly higher than in healthy controls.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28028945            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Variants in BAFF-R gene is associated with chronic lymphocytic leukemia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27468724            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF-R, as the principal receptor of BAFF, not only decreased the apoptosis of B cells and CD8+ T cells by upregulating the expression of Bcl-2 and BclxL, but also promoted B-cell proliferation in immune thrombocytopenia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26749059            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            genetic polymorphism contributes to the pathogenesis of primary antibody deficiency            \u003ca rel=\"nofollow\"\u003e             PMID:                        26613719            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF and BAFF-R are expressed in the thyrocytes derived from patients with either autoimmune thyroid disorders or multinodular goiter, as well in the infiltrating immune cells of Graves' disease and Hashimoto's thyroiditis            \u003ca rel=\"nofollow\"\u003e             PMID:                        26214745            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            There is an increased prevalence of the BAFF-R His159Tyr mutation in patients with Sjogren's syndrome (SS), particularly in those with SS complicated by MALT lymphoma whose disease onset occurred at a younger age.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26097183            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Expression of mutant caspase-9 correlated with a downregulation of BAFFR (B-cell-activating factor belonging to the TNF family (BAFF) receptor) in B cells and ICOS (inducible T-cell costimulator) in T cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25569260            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Variants of TNFRSF13C were associated with common variable immunodeficiency.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26122175            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Negative expression of BAFF-R, but not of BAFF, could be an independent risk factor for progression-free survival and Overall survival in patients with diffuse large B-cell lymphoma treated with standard R-CHOP.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26327569            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the common TLR4-D299G, TLR4-T399I and BAFFR-P21R polymorphisms provide the carriers with a protective advantage against ICU-acquired sepsis; this finding was more profound for medical patients compared to trauma or surgical ones            \u003ca rel=\"nofollow\"\u003e             PMID:                        25454804            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data show significant differences in expression of tumour necrosis factor family (BAFF) receptors BAFF-R, BCMA and TACI in patients with and without anti-Jo-1 or anti-Ro52\/anti-Ro60 autoantibodies.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25301447            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In view of the restricted expression of the BAFF-R on normal cells and the multiple anti-pre-B ALL activities stimulated by this antibody, a further examination of its use for treatment of pre-B ALL is warranted.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24825858            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Availability of BAFF determines BAFF-R and TACI expression on B cells in common variable immunodeficiency.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24809296            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our study demonstrates that BR3 is involved in the survival of cultured epithelial cells due to an autocrine effect of BAFF.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24602383            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF-R, but not BAFF, may have a role in progression-free survival and overall survival in follicular lymphoma            \u003ca rel=\"nofollow\"\u003e             PMID:                        23272079            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BLyS and its receptors are expressed by B lymphocytes in the peripheral blood and the bone marrow of patients with multiple myeloma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23276925            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            P21R\/H159Y TNFRSF13C compound heterozygous mutation and P21R heterozygous mutations were detected in Turkish patients with common variable immunodeficiency.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22699762            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF-R expression is tightly regulated during B-cell development in mouse and human and this exprssion is correlated with posirive selection.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22028296            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            It was also found that NF-kappaB was an important transcription factor involved in regulating BAFF-R expression through one NF-kappaB binding site in the BAFF-R promoter            \u003ca rel=\"nofollow\"\u003e             PMID:                        21607696            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22124120            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The activation profile of diffuse large B-cell lymphomas\/posttransplantation lymphoproliferative disorders was not associated with BAFF\/BAFF-R expression, whereas nuclear p52 activation might be linked to Epstein-Barr virus.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21871426            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The human BAFF-R gene might be regulated via a transcriptional event through one putative NF-kappaB site on the BAFF-R gene promoter.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21744373            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            reduced expression via inhibition of the NF-KappaB pathway in B cells of rheumatoid arthritis patients            \u003ca rel=\"nofollow\"\u003e             PMID:                        21515993            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            primary leukemia B-cell precursors aberrantly express receptors of the BAFF-system, BAFF-R, BCMA, and TACI            \u003ca rel=\"nofollow\"\u003e             PMID:                        21687682            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This is the first study, presenting together the TNFSF members APRIL, BAFF, TWEAK and their receptors in different areas of normal renal tissue and renal cell carcinoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21483105            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BLyS and its receptors might have a potential role in the growth and survival of malignant plasma cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        19731825            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results describe the mechanisms underlying aberrant BAFF-R expression in precursor B acute lymphoblastic leukemia (precursor B-ALL) and mature B chronic lymphocytic leukemia (CLL).            \u003ca rel=\"nofollow\"\u003e             PMID:                        21099364            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF-R was rather specifically related to low growth activity of germinal center B-cell-like -type diffuse large B-cell lymphoma of nodal origin.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21123970            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            inverse correlation between BAFF and APRIL in Kawasaki disease is reversed by IVIG treatment            \u003ca rel=\"nofollow\"\u003e             PMID:                        20945608            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Elevated plasma BAFF and reduced BAFF receptor 3 (BR3) protein expression on peripheral B cells could act as biomarkers for active disease in systemic lupus erythematosus patients            \u003ca rel=\"nofollow\"\u003e             PMID:                        20974656            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            a novel lymphoma-associated mutation in human BAFF-R that results in NF-kappaB activation and reveals TRAF6 as a necessary component of normal BAFF-R signaling.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21041452            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data from BAFF-R-expressing cells suggested potential regulatory sites in TNFRSF13C promoter region.            \u003ca rel=\"nofollow\"\u003e             PMID:                        20554963            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This report is the first showing universal expression of BAFF-R by pre-B ALL cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        20460528            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            IFN-gamma and the NF-kappaB pathway could be involved in regulating the transcription and mRNA expression of BAFF-R gene.            \u003ca rel=\"nofollow\"\u003e             PMID:                        20230666            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the mechanism of transcriptional regulation of BAFF-R            \u003ca rel=\"nofollow\"\u003e             PMID:                        20025535            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF-R is a receptor for the TNF family member ligand, BAFF [review]            \u003ca rel=\"nofollow\"\u003e             PMID:                        12456020            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFFR-mediated NF-kappa B activation and IL-10 production in B cells is downregulated by TNFR-associated factor-3.            \u003ca rel=\"nofollow\"\u003e             PMID:                        12471121            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            crystal structure and interaction with BAFF protein            \u003ca rel=\"nofollow\"\u003e             PMID:                        12715002            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF\/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.            \u003ca rel=\"nofollow\"\u003e             PMID:                        12755599            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Expression of BCMA, TACI, and BAFF-R by multiple myeloma cells support cell growth and survival.            \u003ca rel=\"nofollow\"\u003e             PMID:                        14512299            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study reports the crystal structure of a 24-residue fragment of the cytoplasmic portion of BAFF-R bound in complex with TRAF3.            \u003ca rel=\"nofollow\"\u003e             PMID:                        15585864            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the PVPAT sequence of BAFFR not only functions as a key signaling motif of BAFFR but also determines its signaling specificity in the induction of the noncanonical NF-kappaB pathway            \u003ca rel=\"nofollow\"\u003e             PMID:                        15644327            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            amino acid sequence of genomic DNA from blood of common variable immunodeficiency patients;mutations may result in humoral immunodeficiency            \u003ca rel=\"nofollow\"\u003e             PMID:                        16160919            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            BAFF-R is expressed on most mature B cells and B-cell lymphoproliferative disorders.            \u003ca rel=\"nofollow\"\u003e             PMID:                        16226112            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915058675937,"sku":"BL-2228NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLRWAE2jNAACZo_RFEJ0036_359146cc-3be5-4676-b98b-b18b87fd1d96.jpg?v=1685851863"},{"product_id":"recombinant-human-mouse-rat-gdf8-protein-bl-2256np","title":"Recombinant Human\/Mouse\/Rat GDF-8 Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human\/Mouse\/Rat Growth Differentiation Factor 8 is produced by our Mammalian expression system and the target gene encoding Lys262-Ser375 is expressed.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eO14793\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGrowth\/differentiation factor 8; GDF-8; Myostatin; Mstn; Gdf8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGrowth\/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. It is expressed specifically in developing and adult skeletal muscle. It exists as a homodimer, and interacts with WFIKKN2, leading to inhibit its activity. This protein can act specifically as a negative regulator of skeletal muscle growth. It regulates cell growth and differentiation in both embryonic and adult tissues.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e13.1 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e12-15 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg\/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eActs specifically as a negative regulator of skeletal muscle growth.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eSecreted.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTGF-beta family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            4223           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            601788           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:2660           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000260950           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        30241032            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            the maturation and secretion of myostatin precursor MstnPP and its metabolites in a human muscle cell line, was investigated.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29546591            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Acute high-intensity interval exercise decreased irisin levels and increased myostatin levels.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29558345            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Autosomal Dominant Polycystic Kidney Disease patients with moderately preserved renal function have higher levels of FasL, myostatin and urine TGF-beta1 than controls            \u003ca rel=\"nofollow\"\u003e             PMID:                        29794429            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Tolloid cleavage activates latent GDF8 by destabilizing specific prodomain-growth factor interfaces and primes the growth factor for release from the prodomain.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29343545            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Myostatin pathway is down-regulated in the neuromuscular diseases.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29192144            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the prodomain:GDF8 complex can exist in a fully latent state and an activated or \"triggered\" state where the prodomain remains in complex with the mature domain            \u003ca rel=\"nofollow\"\u003e             PMID:                        29348202            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Higher serum myostatin levels correlated with muscle mass loss, hyperammonemia, and impaired protein synthesis, as reflected by lower serum albumin levels and lower branched-chain amino acid to tyrosine ratio levels. High serum myostatin levels were also associated with a reduced OS rate in LC patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28627027            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Study showed the expression of myostatin in healthy endometrium and a higher expression in endometriosis and endometrial cancer, suggesting myostatin involvement in human endometrial physiology and related pathologies.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28345488            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Studied levels of myostatin in both serum and synovial fluid in patients with knee osteoarthritis and found both correlated with severity of knee osteoarthritis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27878995            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Myostatin (and Smad2) were significantly up-regulated in the failing heart of female patients, but not male patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28465115            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN) in tissue specific aging.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28472635            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            MSTN 153Arg(R) polymorphism is associated with long distance running success.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28007336            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GDF8 promotes ovarian cancer cell migration via ALK4\/5-SMAD2\/3-E-cadherin signaling.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27481097            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results demonstrat that GDF8 stimulates the expression and secretion of CTGF in human granulosa cells and provide evidence that both proteins may play critical roles in the regulation of extracellular matrix formation in these cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27392496            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These studies identify distinctive structural features of GDF11 that enhance its potency, relative to GDF8; however, the biological consequences of these differences remain to be determined.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28257634            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Serum myostatin levels were significantly decreased in heart failure patients and associated with lower extremity muscle wasting.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27390974            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            our data showed a virtual absence of the variant (K) allele in MSTN rs1805086 in Japanese population, and no differences in allele\/genotype frequencies in ACTN3 rs1815739 among centenarians and healthy controls of this country.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27861536            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            MSTN, but not GDF11, declines in healthy men throughout aging.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27304512            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Multivariate regression analysis revealed that myostatin levels correlated significantly with tricuspid annular plane systolic excursion values and right ventricle myocardial performance index among the study patients            \u003ca rel=\"nofollow\"\u003e             PMID:                        27323660            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Study measured circulating myostatin levels in seven inherited muscle diseases using an immunoaffinity LC-MS\/MS approach, found significantly lower serum myostatin concentrations in numerous muscle disease patient populations and the associations with clinical measurements suggests the potential utility of myostatin as a biomarker of genetic muscle disease progression            \u003ca rel=\"nofollow\"\u003e             PMID:                        28074267            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            data indicated that serum myostatin concentration did not correlate with muscle and bone mass in postmenopausal women            \u003ca rel=\"nofollow\"\u003e             PMID:                        27144806            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Myostatin mRNA expression in skeletal muscle was significantly reduced compared with pre-exercise values at all time points with no difference between exercise intensity.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27467217            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Low expression of serum MSTN is associated with Cachexia Prevention in Patients with Medullary Thyroid Cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27165248            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Myostatin was differentially expressed in the muscle and adipose tissue in relation to physical activity and dysglycaemia            \u003ca rel=\"nofollow\"\u003e             PMID:                        26572800            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our results suggest that serum levels of myostatin and irisin are related in patients with type 2 diabetes            \u003ca rel=\"nofollow\"\u003e             PMID:                        26438394            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Matrix metalloproteinase 14 was highly expressed in uterine leiomyoma and correlated with myostatin and activin A mRNA expression. Moreover, MMP14 and myostatin mRNA expression correlated significantly and directly with the intensity of dysmenorrhea.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26138721            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            A synthetic peptide corresponding to this decorin region dose-dependently inhibited the response to myostatin in cardiomyocytes            \u003ca rel=\"nofollow\"\u003e             PMID:                        27559042            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Findings suggest that GDF8 and CTGF may play critical roles in the regulation of proliferative events in human granulosa cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26577677            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Myostatin concentrations in plasma and protein expression in placental tissue are significantly higher in women with preeclampsia. Cytokine production by first-trimester placental tissues was altered following myostatin treatment.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25736326            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Myostatin is a well-described negative regulator of postnatal skeletal and cardiac muscle mass and modulates metabolic processes. It functions in the heart, skeletal muscle, and brain. Review.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27034275            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Plasma myostatin levels are increased in chronic obstructive pulmonary disease patients who have cor pulmonale.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26998756            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In human granulosa cells, GDF8 may play an important role in the modulation of cellular responsiveness to gonadotropins and in the regulation of ovarian steroid production, most likely as a luteinization inhibitor.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26607022            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Plasma myostatin might be suitable in predicting weight regain after marked weight loss, but no association with weight loss was observed in patients undergoing a non-surgical weight loss program.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26393401            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Plasma MSTN level was elevated in an early stage of CKD, which could be involved in the progression of sarcopenia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26502079            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            it is becoming clearer that besides its conventional role in muscle, myostatin plays a critical role in metabolism. Hence, molecular mechanisms by which myostatin regulates several key metabolic processes need to be further explored.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26305594            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The aim of this study was to investigate MSTN polymorphisms in an elderly sarcopenic population in Turkey and determine how they relate to sarcopenia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26046327            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            There is a significant decrease in levels of circulating myostatin in postsurgical acute phase reaction.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25749570            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Myostatin myocardial expression increases in the presence of structural cardiomyopathy either of hypertensive or other origin.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25915890            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In contrast to elite endurance and power track and field athletes, the MSTN 153RR genotype was not found in short distance-swimmers, and among the long distance-swimmers it was not associated with top level swimming performance.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25936293            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Lower serum myostatin independently associated with MetS, central obesity, low HDL-C, and high triglycerides after adjustment. Higher serum myostatin is associated with favorable metabolic profiles.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25254550            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results indicate that GDF8 down-regulates PTX3 expression via SMAD-dependent signaling in human granulosa cells suggesting a potential role for GDF8 in the regulation of follicular function.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25641196            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26086422            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This is the first demonstration of a spatial asymmetry in the expression pattern of Mstn\/IGF-I in healthy hearts, which is likely to play a role in the different growth regulation of left vs. right ventricle            \u003ca rel=\"nofollow\"\u003e             PMID:                        25591711            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Myostatin expression in placental tissue is altered under stress conditions (e.g. obesity and abnormal glucose metabolism) found in pregnancies complicated with gestational diabetes mellitus.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25443639            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            we show that the K153R mutation significantly increases the rate of proteolysis of promyostatin by furin, but has no effect on the activity of the latent complex or the cleavage of the latent complex by bone morphogenetic protein 1 (BMP-1).            \u003ca rel=\"nofollow\"\u003e             PMID:                        25543063            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            MyoD acts to promote SC proliferation and transition of cells into differentiation, while myogenin is known to drive terminal differentiation            \u003ca rel=\"nofollow\"\u003e             PMID:                        25108351            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            role of myostatin in cardiovascular disease and cachexia            \u003ca rel=\"nofollow\"\u003e             PMID:                        24680839            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Myostatin localization was positively identified in extravillous trophoblast. Myostatin positively affected proliferation and migration of extravillous trophoblast.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25093622            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The present study demonstrated that the variant alleles of MSTN A55T and K153R polymorphisms could significantly enhance muscle hypertrophy in response to strength training among Han Chinese men.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24479661            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915100979425,"sku":"BL-2256NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLY6AW1a_AADEpvBizaY096_11a4907c-4925-4473-9dea-35f3b1d639a6.jpg?v=1685853279"},{"product_id":"recombinant-human-gitr-protein-fc-tag-bl-2290np","title":"Recombinant Human GITR Protein (C-mFc)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant human Glucocorticoid Induced TNF Receptor Family Related Gene is produced by our Mammalian expression system and the target gene encoding Gln26-Glu161(Thr45Ala) is expressed with a mouse IgG1 Fc tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eQ9Y5U5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTumor necrosis factor receptor superfamily member 18; TNFRSF18; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a  secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2\/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1\/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation\/lymphocyte activation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e41.1 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e40-55 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by SEC-HPLC. (Regularly tested)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eReceptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2\/NIK pathway.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            11914           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            603905           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:8784           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000328207           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        28101786            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            a novel molecular mechanism by which MBD4 inhibits GITR expression in a DNMT1-dependent manner            \u003ca rel=\"nofollow\"\u003e             PMID:                        28542810            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Aberrant expression of GITR may contribute to systemic lupus erithematosus pathogenesis. Glucocorticoid may achieve its therapeutic effect partly by inducing GITR expression on Tresps rather than Tregs, which initiates the apoptosis of Tresp cells in SLE patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25293713            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GITR expression can enhance the sensitivity to Bortezomib by inhibiting Bortezomib-induced NF-kappaB activation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25973846            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GITR is a crucial player in differentiation of thymic regulatory T cells and expansion of regulatory T cells, including both thymic regulatory T cells and peripheral regulatory T cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25961057            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data may suggest a key role of regulatory GITR+CD25 low\/-CD4+ T cells subset in the modulation of the abnormal immune response in lupus erythematosus (SLE) patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25256257            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            results suggest that the GITR rs3753348 polymorphism may be involved in the development and susceptibility of CWP.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25445616            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these results show a higher susceptibility to apoptosis in patients' versus controls' T(reg) cells, suggesting that GITR is a T(reg)-cell marker that would be primarily involved in T(reg)-cell survival rather than in their suppressor function.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23929911            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our findings indicate the possible involvement of GITR-GITRL pathway in the pathogenesis of pSS.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23935647            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GITR acts as a potential tumor suppressor in MM.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23785514            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data indicate that the mRNAs of CTLA-4 and GITR genes were expressed at lower levels in CVID patients compared to control group.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23432692            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GITR is pathologically expressed on Treg cells in systemic lupus erythematosus.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22516990            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Liver tumor Tregs up-regulate the expression of glucocorticoid-induced tumor necrosis factor receptor compared with Tregs in tumor-free liver tissue and blood.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22911397            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results suggest that GITR expression might indicate a molecular link between steroid use and complicated acute sigmoid diverticulitis. Increased MMP-9 expression by GITR signalling might explain morphological changes in the colonic wall in diverticulitis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22309286            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The regulatory SNPs identified in this study will provide useful information for understanding the relevance of sequence polymorphisms in populations of different background and may serve as a basis to study parasite susceptibility in association studies            \u003ca rel=\"nofollow\"\u003e             PMID:                        21445534            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GITRL may contribute to disease pathophysiology and resistance to direct and Rituximab-induced NK reactivity in CLL            \u003ca rel=\"nofollow\"\u003e             PMID:                        22064350            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GITR, which transmits a signal that abrogates regulatory T cell functions, was elevated in early rheumatoid arthritis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21670968            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            DCs transfected with mRNA encoding a humanized anti-CTLA-4 mAb and mRNA encoding a soluble human GITR fusion protein enhance the induction of anti-tumor CTLs in response to DCs.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22028176            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Findings suggest that GITR-expression of TILs is associated with cancer progression.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21694467            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Although GITR transgene costimulation can therapeutically enhance T helper (Th) type 2 cell responses, GITR-GITR ligand interactions are not required for development of Th2-mediated resistance or pathology.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21705620            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data indicate that CD4(+) CD25(low) GITR(+) cells represent a low percentage of the CD4(+) T-cell population (0.32-1.74%) and are mostly memory cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21557210            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            study concludes, the rs3753348 C\/G SNP in the GITR is associated with Hashimoto's disease prognosis and expression on T(reg) and T(eff) cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        21592113            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            GITR rapidly recruits TNF receptor-associated factor 2 (TRAF2) in a ligand-dependent manner; data indicate that the cytoplasmic domain of GITR contains a single TRAF binding site where acidic residues 202\/203 and 211-213 are critical for this interaction.            \u003ca rel=\"nofollow\"\u003e             PMID:                        15944293            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Since regulatory T-cells are localized in the vicinity of GITRL-expressing cells in atopic dermatitis skin, the GITR\/GITRL interaction may serve to perpetuate the inflammation locally.            \u003ca rel=\"nofollow\"\u003e             PMID:                        16955181            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This protein has been shown to stimulate T cell-mediated antitumor immunity in mice, and now in a human tumor cell line.            \u003ca rel=\"nofollow\"\u003e             PMID:                        17360848            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These data suggest that, despite abnormal GITR expression during HIV infection, GITR triggering enhances HIV-specific CD4(+) T cell cytokine expression and protects HIV-specific CD4(+) T cells from apoptosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        17538882            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            although GITR is an activation marker for NK cells similar to that for T cells, GITR serves as a negative regulator for NK cell activation            \u003ca rel=\"nofollow\"\u003e             PMID:                        18230609            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CD4(+)CD25(+) effector memory T-cells expressing CD134 and GITR seem to play a role in disease mechanisms, as suggested by their close association with disease activity and their participation in the inflammatory process in Wegener's granulomatosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        18723571            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            mechanism of IgG4 induction by regulatory cells involves GITR-GITR-L interactions, IL-10 and TGF-beta.            \u003ca rel=\"nofollow\"\u003e             PMID:                        18924213            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data show that in humans GITRL expression subverts NK cell immunosurveillance of AML.            \u003ca rel=\"nofollow\"\u003e             PMID:                        19155305            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            mRNA level for CTLA-4, ICOS1, IL-23, IL-27, SMAD3 and GITR were lower in T regulatory cells of children with diabetes compared to the control patients            \u003ca rel=\"nofollow\"\u003e             PMID:                        19547759            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915061887201,"sku":"BL-2290NP","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-g-csfr-protein-fc-tag-bl-2292np","title":"Recombinant Human G-CSFR Protein (C-Fc)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Granulocyte Colony-stimulating Factor Receptor is produced by our Mammalian expression system and the target gene encoding Glu25-His627 is expressed with a human IgG1 Fc tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eQ99062\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eCD114 antigen; CD114; colony stimulating factor 3 receptor (granulocyte); CSF3R; Csfgr; G-CSF R; G-CSF receptor; GCSFR; G-CSFR; GCSFRG-CSF-R\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGranulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, the protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine\/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e93.7 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e110-130 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eReceptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e[Isoform 2]: Secreted.; Cell membrane; Single-pass type I membrane protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eType I cytokine receptor family, Type 2 subfamily\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            2439           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            138971           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:1441           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000362195           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        29338593            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            we report here for the first time changes in the allele frequencies of CSF3R-T618I and SETBP1-G870S with response to ruxolitnib as well as insights into the clonal evolution of CNL under selective pressure from ruxolitinib.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28209656            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CSF3R genetic polymorphism occurred more frequently in the individuals with Septic Arthroplasty failure - Periprosthetic Joint Infection.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29305046            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            G-CSF-R is C-mannosylated at W318 and that this C-mannosylation has role(s) for myeloid cell differentiation through regulating downstream signaling.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29501745            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CSF3R mutations co-occur with CEBPA mutations in pediatric acute myeloid leukemia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27143256            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            we have expanded the region of the CSF3R cytoplasmic domain in which truncation or missense mutations exhibit leukemogenic capacity, which will be useful for evaluating the relevance of CSF3R mutations in patients and helpful in defining targeted therapy strategies.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28439110            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            our data demonstrates that E6AP facilitates ubiquitination and subsequent degradation of G-CSFR leading to attenuation of its downstream signaling and inhibition of granulocytic differentiation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28578910            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            study aimed to identity and characterize novel CSF3R extracellular missense mutations from exome sequencing of leukemia patients; results show the structural and functional importance of conserved extracellular cysteine pairs in CSF3R            \u003ca rel=\"nofollow\"\u003e             PMID:                        28652245            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            a central role of enhanced Mapk signaling in CSF3R-induced leukemia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28031554            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CSF3R T618I mutation is associated with Chronic neutrophilic leukemia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28209919            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            biallelic CSF3R mutations were identified In the group of congenital neutropenia patients; CSF3R mutant clones are highly dynamic and may disappear and reappear during continuous granulocyte colony-stimulating factor (G-CSF) therapy. The time between the first detection of CSF3R mutations and overt leukemia is highly variable            \u003ca rel=\"nofollow\"\u003e             PMID:                        27270496            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Co-occurrence of mutations in CSF3R and CEBPA in a well-defined AML subset, which uniformly responds to JAK inhibitors; this paves the way to personalized clinical trials for this disease.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27034432            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The quantitative methods used in this study have shown non-altered expression levels of different microglial markers (Iba-1, Cd11b and CD68), together with increased expression of IL6, IL10RA, colony stimulating factor 3 receptor and toll-like receptor 7 in the thalamus in FFI, which explains the seemingly contradictory results of the previous studies.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27056979            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study proposes that acquisition of CSF3R mutations may represent a mechanism by which myeloid precursor cells carrying the ELANE mutations evade the proapoptotic activity of the Neutrophil Elastase mutants in SCN patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28073911            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CSF3R expression is significantly upregulated in human masticatory mucosa during wound healing            \u003ca rel=\"nofollow\"\u003e             PMID:                        28005267            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results indicate that granulocyte-colony stimulating factor receptor, tissue factor, and vascular endothelial growth factor receptor bound vascular endothelial growth factor expression as well as their co-expression might influence breast cancer biology.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27629739            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I            \u003ca rel=\"nofollow\"\u003e             PMID:                        26475333            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CSF3R mutations, mechanisms of mutations, and their contributions to the myeloid malignancies (Review)            \u003ca rel=\"nofollow\"\u003e             PMID:                        26956865            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In conclusion, rhCSF3 can promote melanocyte proliferation through CSF3R without affecting tyrosinase activity            \u003ca rel=\"nofollow\"\u003e             PMID:                        25666388            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CSF3R mutations are associated with congenital neutropenia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26324699            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The leukemogenic potential of G-CSFRIV is associated with the Stat5-dependent dysregulation of miR-155 and the target genes of this miRNA.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25730818            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            No CSF3R mutations were found in cases of MDS, JMML or ET. The only mutation found in the CALR gene was a frameshift (p.L367 fs) in one ET patient.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25858548            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The SETBP1 and ASXL1 mutations have pathogenetic roles in CSF3R-mutated chronic neutrophilic leukemia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25850813            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CSF3R polymorphisms are associated with chronic neutrophilic leukemia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25708716            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CSF3R T618I mutation as a disease-specific marker of atypical CML post allo-SCT in two patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24614839            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the incorporation of CSF3R mutation testing can be a useful point-of-care diagnostic to evaluate the presence of a clonal myeloid disorder, as well as providing the potential for genetically informed therapy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25533830            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            study to see if the CSF3R p.T618I mutation was present in acute myelogenous leukemia (AML) and solid tumors of Korean patients; data revealed that CSF3R p.T618I mutation occurred in an AML with myelodysplasia-related changes and a refractory anemia with excess blasts in transformation            \u003ca rel=\"nofollow\"\u003e             PMID:                        25404019            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            A de novo CSF3R mutation was associated with the transformation of myeloproliferative neoplasm to atypical chronic myeloproliferative leukemia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25865944            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            mutation analysis of CSF3R, SETBP1 and CALR should be included in the diagnostic criteria for chronic neutrophilic leukemia            \u003ca rel=\"nofollow\"\u003e             PMID:                        25316523            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The expression of G-CSFR before preoperative irradiation may predict the radiosensitivity of rectal cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24574781            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            this study describes a novel genetic Severe congenital neutropenia type in 2 unrelated families associated with recessively inherited loss-of-function mutations in CSF3R, encoding the granulocyte colony-stimulating factor (G-CSF) receptor.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24753537            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            concurrent CSF3R and SETBP1 mutations are associated with Chronic neutrophilic leukemia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24445868            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            frequency of CSF3R mutations is highly prevalent among acute myeloid leukemia patients secondary to severe congenital neutropenia compared to de novo AML.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24746896            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The detection of both RUNX1 and CSF3R mutations could be used as a marker for identifying Congenital neutropenia patients with a high risk of progressing to leukemia or myelodysplastic syndromes.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24523240            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Thr-615 and Thr-618 sites of membrane-proximal mutations are part of an O-linked glycosylation cluster. Mutation at these sites prevents O-glycosylation of CSF3R and increases receptor dimerization.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24403076            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Fbw7 together with GSK3beta negatively regulates G-CSFR expression and its downstream signaling.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23820376            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Mice transplanted with human CSF3R T618I-expressing hematopoietic cells developed a myeloproliferative disorder characterized by overproduction of granulocytes and granulocytic infiltration of the spleen and liver, which was uniformly fatal.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24081659            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The stimulating factor 3 receptor mutation (CSF3R-T595I) found in acute myeloid leukemia patients was found to have ligand independent activation properties.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23508011            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            findings show CSF3R somatic mutations can be identified in 4 percent of the patients with chronic myelomonocytic leukemia (CMML); these mutations, which affect distinct residues in CSF3R are frequently associated with mutations in ASXL1 gene and have a poor prognostic impact on overall and AML-free survival            \u003ca rel=\"nofollow\"\u003e             PMID:                        23774674            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In myelodysplastic syndromes, altered CD114 distribution was more informative than density changes. In CML, CD114 density was significantly decreased on early blasts and expression was essentially limited to late blasts.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23897249            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            A subpopulation of GCSFR positive neuroblastoma cells exhibit enhanced tumorigenicity and a stem cell phenotype.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23687340            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Certain missense single nucleotide polymorphisms, especially which are placed in the conserved regions of G-CSFR may possess the capacity to influence the response to G-CSF treatment.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23159284            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Mutations in CSF3R are common in patients with CNL or atypical CML and represent a potentially useful criterion for diagnosing these neoplasms.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23656643            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CSF3R gene polymorphism plays a significant role in hematopoietic stem and progenitor cells for transplantation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22796466            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            An acquired CSF3R mutation in an adult chronic idiopathic neutropenia patient who developed acute myeloid leukaemia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22146088            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Pretreatment of PMNs with IFN-gamma or G-CSF for a long-time (22 h)induced a significant lower fungal damage against biofilms compared with planktonic cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21641233            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Gemcitabine can enhance in vitro the expression rate of bone marrow G-CSFR in chronic myeloid leukemia patients at chronic or blastic phases.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21129254            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Two cases of X-linked neutropenia are reported that evolved to acute myeloid leukemia or myelodysplasia, with acquisition of G-CSF receptor mutations.            \u003ca rel=\"nofollow\"\u003e             PMID:                        19794089            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            There was no significant difference in expression rate of G-CSFR on CD34+ cells between aplastic anemia, myelodysplastic syndrome, and controls.            \u003ca rel=\"nofollow\"\u003e             PMID:                        19099633            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CD123+CD34+CD38- cells exhibited lower expression of G-CSF receptors, which might partly explain why MDS clone responds worse to G-CSF in vitro and in vivo.            \u003ca rel=\"nofollow\"\u003e             PMID:                        20819538            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915058807009,"sku":"BL-2292NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLbSAc5w4AACccZCMhQA333_6473b952-e1ce-485e-b9d7-5e892d41fb72.jpg?v=1685851869"},{"product_id":"recombinant-cynomolgus-gitr-ligand-protein-his-tag-bl-2293np","title":"Recombinant Cynomolgus GITR Ligand Protein (C-6His)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Cynomolgus TNF Superfamily Member 18 is produced by our Mammalian expression system and the target gene encoding Glu74-Ser199 is expressed with a 6His tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003ca title=\"A0A2K5UCD9\" target=\"_blank\" href=\"https:\/\/www.uniprot.org\/uniprotkb\/A0A2K5UCD9\/entry\"\u003eA0A2K5UCD9\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTumor necrosis factor ligand superfamily member 18; TNFSF18; Activation-inducible TNF-related ligand; Glucocorticoid-induced TNF-related ligand; AITRL; GITRL; TL6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18\/AITR\/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells.  TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e15.3 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e15-20 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBiologically active. Please contact us to obtain bioactivity data.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915070669025,"sku":"BL-2293NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLbSAAT0MAACrdHwjiXk108_f51569be-f61f-428d-9a56-15eea3502fe5.jpg?v=1685852186"},{"product_id":"recombinant-human-plgf-2-protein-his-tag-bl-2323np","title":"Recombinant Human PLGF-2 Protein (C-6His)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Placenta Growth Factor is produced by our Mammalian expression system and the target gene encoding Leu19-Arg170 is expressed with a 6His tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003ca title=\"P49763-3\" target=\"_blank\" href=\"https:\/\/www.uniprot.org\/uniprotkb\/P49763\/entry#P49763-3\"\u003eP49763-3\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003ePlGF2; PlGF-2; PGF; PLGF; PlGF2; PlGF; PGFL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003ePlacental growth factor is a protein that in humans is encoded by the PGF gene. It is a secreted protein and belongs to the PDGF\/VEGF growth factor family. Alternate splicing results in at least three human mature PlGF forms containing 131 (PlGF‑1), 152 (PlGF‑2), and 203 (PlGF‑3) amino acids (aa) respectively. PlGF is mainly found as a variably glycosylated, secreted, 55 ‑ 60 kDa disulfide linked homodimer.The protein is a member of the VEGF (vascular endothelial growth factor) sub-family-a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PlGF (especially PlGF‑1) and some forms of VEGF can form dimers that decrease the angiogenic effect of VEGF on VEGF R2. PlGF‑2, like VEGF164\/165, shows heparin‑dependent binding of neuropilin (Npn)‑1 and Npn‑2, and can inhibit nerve growth cone collapse. Circulating PlGF often correlates with tumor stage and aggressiveness, and therapeutic PlGF‑2 antibodies are being investigated for their ability to inhibit tumor growth and angiogenesis.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e18.2 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e25-30 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg\/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915099767009,"sku":"BL-2323NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLbiABh9VAACQH19ZRiY435_b7291d23-5bb9-47c7-9011-a7a5a699abf4.jpg?v=1685853228"},{"product_id":"recombinant-human-ifnar2-protein-fc-tag-bl-2334np","title":"Recombinant Human IFNAR2 Protein (C-Fc)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Interferon Alpha\/Beta Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ile27-Lys243 is expressed with a human IgG1 Fc tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP48551\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eInterferon Alpha\/Beta Receptor 2; IFN-R-2; IFN-Alpha Binding Protein; IFN-Alpha\/Beta Receptor 2; Interferon Alpha Binding Protein; Type I Interferon Receptor 2; IFNAR2; IFNABR; IFNARB\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eInterferon α\/β Receptor 2 (IFN-α\/β R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN-α\/β R1 to form the signaling receptor complex for the family of α and β IFN subtypes. By alternative splicing, IFN-α\/β R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN-α\/β R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN-α\/β R1, resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes, monocytes, and granulocytes, although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets, IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e51.8 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e67-75 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAssociates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-mediated STAT1, STAT2 and STAT3 activation.; Potent inhibitor of type I IFN receptor activity.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eType II cytokine receptor family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            5433           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            602376           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:3455           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000343957           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        29997210            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            Report lowered serum IFNAR2 levels in multiple sclerosis patients are elevated on treatment with interferon-beta.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27613121            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            this study shows that the surface expression levels of the common IFN-alpha\/beta receptor subunit 2 are significantly higher on plasmacytoid dendritic cells from females in comparison to males            \u003ca rel=\"nofollow\"\u003e             PMID:                        27891600            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            A very small percentage of the pancreatic tumors showed strong expression of the IFNAR-2c.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25072284            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Lack of expression of functional IFNAR2 does not seem to be the major cause of interferon resistance in hepatitis C virus patients receiving standard interferon therapy.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26176069            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The effects of two functional polymorphisms, type I interferon receptor 2 gene (IFNAR2)-F8S and interleukin-10 receptor subunit beta gene (IL10RB)-K47E, on chronic hepatitis B virus (HBV) infection, were investigated.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23745570            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            IFNAR2 overexpression was observed in various histological types of lung cancer, and appears to be associated with lung cancers that behave aggressively.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22236545            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In this study we have characterized the Stat2-IFNaR2 interaction and examined its role in IFNalpha signaling            \u003ca rel=\"nofollow\"\u003e             PMID:                        11786546            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c            \u003ca rel=\"nofollow\"\u003e             PMID:                        12105218            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Expression and signaling activity of interferon alpha\/beta receptors modulates dendritic cell (DC) responsiveness during terminal maturation and differentiation of monocyte-derived DCs.            \u003ca rel=\"nofollow\"\u003e             PMID:                        12218119            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Subunit 2 of the interferon alpha receptor (IFNaR2) is bound more avidly to Stat2 than is phosphorylated IFNaR1.            \u003ca rel=\"nofollow\"\u003e             PMID:                        12220192            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Administration as a complex with sIFNAR-2 may provide a method of enhancing the delivery and effectiveness of type I interferons in Burkitt lymphoma in scid mice.            \u003ca rel=\"nofollow\"\u003e             PMID:                        14980076            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            IFNaR2, a subunit of the type I IFN receptor, is proteolytically cleaved in a regulated manner.            \u003ca rel=\"nofollow\"\u003e             PMID:                        15286706            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Dynamics of the IFNAR2 extracellular domain binding site reveal highly flexible loop segments and a malleable binding surface interacting with the IFN ligand supported by a more rigid scaffold which stabilizes the binding site conformation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        15287740            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            A dynamic model for the IFN-alpha\/receptor complex predicts that IFNAR2 and IFNAR1 are probably anchored in close proximity on the cell surface and that upon IFN binding, the complex assumes a closed form, resulting in activation of intracellular kinases.            \u003ca rel=\"nofollow\"\u003e             PMID:                        15449939            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            IFNaR2 intracellular domain transcriptional modulation is dependent upon the carboxyl-terminal transactivation domain of Stat2.            \u003ca rel=\"nofollow\"\u003e             PMID:                        15717316            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Rapid inhibition of MAPK signaling and anti-proliferation effect via JAK\/STAT signaling by interferon-alpha in hepatocellular carcinoma cell lines.            \u003ca rel=\"nofollow\"\u003e             PMID:                        16054712            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Oveexpression of IFNAR2 is associated with hepatocellular carcinoma            \u003ca rel=\"nofollow\"\u003e             PMID:                        16106266            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Hepatic IFNAR2c mRNA expression appears to correlate inversely with the fibrosis stage and age in hepatitis C infection.            \u003ca rel=\"nofollow\"\u003e             PMID:                        16518956            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Monocyte-derived dendritic cells can modulate their sensitivity to two IFN subtypes by differential regulation of the IFNAR subunits.            \u003ca rel=\"nofollow\"\u003e             PMID:                        16624932            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            IFNAR2 cytoplasmic domain serves to link STAT4 to the IFNAR as a pre-assembled complex that facilitates cytokine-driven STAT4 activation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        17095088            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            binding of IFN-alpha8 rather than binding of IFN-alpha2 to IFNAR-2 leads to activation and subsequent antiproliferative activity despite the same antiviral activity in renal cell carcinoma            \u003ca rel=\"nofollow\"\u003e             PMID:                        17572016            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The intensity and distribution of IFNAR-2 may predict the response to therapy with IFN-alpha and IFN-beta in pancreatic cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        17667505            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High IFNAR2 is associated with renal cell carcinoma metastasis            \u003ca rel=\"nofollow\"\u003e             PMID:                        17697365            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results demonstrated that FNAR2-extracellular domain interact differentially with two individual IFN-alphas, suggesting the mutual interaction between multiple IFN-alpha subtypes during the competition for binding to the receptor.            \u003ca rel=\"nofollow\"\u003e             PMID:                        18027911            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The data suggest that liberation of the IFNaR2-ICD by regulated proteolysis could trigger a novel mechanism for moving the transcription factor Stat2 to the nucleus.            \u003ca rel=\"nofollow\"\u003e             PMID:                        18456457            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor            \u003ca rel=\"nofollow\"\u003e             PMID:                        18456658            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Findings show that interferon-alpha\/beta receptor (IFNAR)-2 isoforms are important regulators of the responsiveness to endogenous and systemically administered interferon beta (IFNbeta).            \u003ca rel=\"nofollow\"\u003e             PMID:                        18971450            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results suggest that zinc, especially polaprezinc, enhances the expression of type 1 interferon 2 receptor in U937 cells, thereby inducing production of the anti-viral protein 2'-5'OAS.            \u003ca rel=\"nofollow\"\u003e             PMID:                        19362011            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Ep-CAM is a potentially useful marker for resistance to INFalpha\/5-FU therapy, especially in IFNAR2-positive cases.            \u003ca rel=\"nofollow\"\u003e             PMID:                        19401692            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The IFNAR2-8SS genotype was associated with HBeAg negative patients; IFNAR2-8F allele was associated with the risk to high viral loads; the IFNAR2-8FF genotype predisposed to higher MxA gene induction and correlated with sustained IFN response.            \u003ca rel=\"nofollow\"\u003e             PMID:                        19714778            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915067850977,"sku":"BL-2334NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLbqAcX4oAACJ4fBc_9g603_e199a3af-388f-48ce-befa-862249eb3fa1.jpg?v=1685852088"},{"product_id":"biotinylated-human-egfr-viii-protein-his-avi-tag-bl-2394np","title":"Biotinylated Human EGFR vIII Protein (C-6His-Avi)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBiotinylated Recombinant Human Epidermal Growth Factor Receptor\/Receptor Tyrosine Protein Kinase ErbB1 is produced by our Mammalian expression system and the target gene encoding Leu25-Ser378 is expressed with a 6His, Avi tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003ca title=\"NP_001333870\" target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/protein\/NP_001333870\"\u003eNP_001333870\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eEpidermal growth factor receptor; EGFR; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EGFR\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain. The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain. Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2, resulting in cell signaling, heterodimerization tyrosine phosphorylation and kinase activation. It can bind EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, epigen, and so on. Its signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR is overexpressed in different tumors. Several anti-cancer drugs use EGFR as target.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e41.5 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e60-90 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"20μg","offer_id":43915209081057,"sku":"BL-2394NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLb-ACoImAADIOJew8ss021.jpg?v=1685852083"},{"product_id":"recombinant-human-tdgf1-protein-fc-tag-bl-0019np","title":"Recombinant Human TDGF1 Protein (C-Fc)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Teratocarcinoma-derived Growth Factor 1 is produced by our Mammalian expression system and the target gene encoding Leu31-Ser169 is expressed with a human IgG1 Fc tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP13385\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTeratocarcinoma-derived growth factor 1;Cripto-1 growth factor;CRGF;Epidermal growth factor-like cripto protein CR1;TDGF1;CRIPTO\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTeratocarcinoma-derived growth factor 1(TDGF1) is a Cell membrane protein and contains 1 EGF-like domain. The protein plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. It also may play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e42.8 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e40-60 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eCell membrane; Lipid-anchor, GPI-anchor. Secreted.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eEGF-CFC (Cripto-1\/FRL1\/Cryptic) family\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            11701           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            187395           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:6997           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000296145           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        29223130            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            Targeting the Cripto-1\/TAK-1\/NF-kappaB\/Survivin pathway may be an effective approach to combat apoptosis resistance in cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29807222            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Knockdown of Cripto-1 inhibits the proliferation, migration, invasion, and angiogenesis in prostate carcinoma cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29358554            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results identified elevated CR-1 expression in esophageal squamous cell carcinoma (ESCC) specimens which correlated to poor prognosis of the patients. CR-1 high cells isolated from ESCC cells possess cancer stem-like cells (ECSLC) properties.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28431580            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These results highlight a functional role for CRIPTO and GRP78 in prostate cancer metastasis and suggest that targeting CRIPTO\/GRP78 signaling may have significant therapeutic potential.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28394345            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            PGAP6 plays a critical role in Nodal signaling modulation through CRIPTO shedding.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27881714            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Upregulation of cripto-1 is associated with prostate cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28098905            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the miR-15b expression is negatively associated with the cripto-1 expression in glioma cells. miR-15b may subsequently impair growth and invasion of glioma cells through targeted regulation of cripto-1.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27082313            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These findings suggest that CRIPTO expression may be a useful serological marker for diagnostic and\/or prognostic purposes during germ cell cancer management.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26654129            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            serum CR-1 is a useful diagnostic and prognostic marker for nonsmall cell lung cancer patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26109366            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Cripto-1 overexpression contributes to aggressiveness and poor prognosis of hepatocellular carcinoma            \u003ca rel=\"nofollow\"\u003e             PMID:                        26375669            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The main signaling pathways mediating Cripto-1 effects include Nodal-dependent (Smad2\/3) and Nodal-independent (Src\/p44\/42\/Akt) signaling transduction pathways            \u003ca rel=\"nofollow\"\u003e             PMID:                        26327334            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Cripto-1 is a novel and dynamically regulated effector of stem cell functions in colorectal cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26343543            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these findings suggest a novel molecular network, involving CRIPTO, AKT, and FGFR signaling, in favor of the emergence of mesenchymal-like cancer cells during the development of aggressive prostate tumors.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25596738            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Report lower gene expression of Cripto in endometriosis but difference not maintained at protein level.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25228630            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Treatment of U-87 MG cells with CR-1 leads to higher expression of drug efflux protein MDR-1 in the CR-1 positive subpopulation, indicating correlated induction of these two proteins.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25658584            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These findings clearly suggest that the downregulation of miR-15a-16 with Cripto amplification may be involved in the development of nonsmall cell lung cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24500260            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Snail represses Cripto-1 gene by direct transcriptional interaction            \u003ca rel=\"nofollow\"\u003e             PMID:                        25889638            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CR-1 expression in glioblastoma multiforme(GBM)tissue and blood; CR-1 plasma levels from GBM patients were elevated compared with normal; CR-1 concentrations higher than normal correlated with shorter overall survival; identified CR-1 in different areas of GBM tissue including perivascular tumor cells and endothelial cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        24521322            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the functional analysis of the main associated locus identified a causal variant in the 5'UTR of CRIPTO gene which is able to strongly modulate CRIPTO expression through an AP-1-mediate transcriptional regulation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25629528            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our findings suggest that high Cripto-1 expression might be involved in the development of bladder cancer and a potentially effective prognostic marker in bladder cancer patients            \u003ca rel=\"nofollow\"\u003e             PMID:                        25326807            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Over expression of Cripto-1 was correlated with the occurrence, development, metastasis and malignant degree of lung adenocarcinoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25796148            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these findings identify the CRIPTO\/GRP78 pathway as a developmentally conserved regulator of fetal and adult mammary stem cell behavior ex vivo, with implications for the stem-like cells found in many cancers.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24749068            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study demonstrated CR-1 expression in the placental bed, its increased expression in creta placentas, and EVT cells as the main CR-1-producing cell type.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25165718            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data suggest that the high expression of Cripto-1 (CR-1) may play an important role in the progression of non-small cell lung cancer (NSCLC), and CR-1 expression may offer a valuable marker for predicting the outcome of patients with NSCLC.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24870591            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Tumors from NSCLC patients with EGFR-activating mutations that were intrinsically resistant to EGFR-TKIs expressed higher levels of CRIPTO1 compared with tumors from patients that were sensitive to EGFR-TKIs.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24911146            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Cripto is overexpressed in colonic neoplasms and is related to cancer cell migration\/invasion.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24379580            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The significance of cell surface CR-1 expression in human melanoma cells, was examined.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23574716            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Cross-talk between Cripto-1 and the Wnt\/beta-catenin signaling pathway might play a role in mammary transformation leading to a more aggressive behavior of mammary cancer cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23022962            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Offer some insight into the transcriptional regulation of CR-1 gene expression and its critical role in the pathogenesis of human cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23129342            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            human testicular tumors showed upregulation of NODAL and CRIPTO that was proportional to invasiveness and to the number of malignant cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23034635            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Cripto\/GRP78 modulates the TGF-beta pathway in development and oncogenesis [review]            \u003ca rel=\"nofollow\"\u003e             PMID:                        22306319            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22542493            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Cripto-1 plays a role in the malignant transformation of oral mucosa and is involved in the tumorigenesis and progression of oral squamous cell carcinoma by promoting the growth and migration of malignant cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21824804            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High CRIPTO-1 is associated with cutaneous melanoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21863025            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Disturbed expression of endometrial activin A, cripto , and follistatin suggests a dysfunction of the activin pathway in endometriosis\/endometrioma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21496809            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            work firstly provides human genetic evidence of TDGF1 involved in the pathogenesis of ventricular septal defects            \u003ca rel=\"nofollow\"\u003e             PMID:                        19853938            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            expression of CR-1 may alter the physiochemical properties of the plasma membrane resulting in an enhancement of intercellular transfer of cellular signaling components which may account for the paracrine activity of CR-1.            \u003ca rel=\"nofollow\"\u003e             PMID:                        21055389            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results demonstrate that CR-1 expression is enriched in an undifferentiated, tumorigenic subpopulation and is regulated by key regulators of pluripotent stem cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        20549704            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            molecular model of activin receptor-like kinase 4\/Cripto\/Nodal complex built by homology modeling as well as docking tests aimed at identifying potential binding epitopes            \u003ca rel=\"nofollow\"\u003e             PMID:                        20629020            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TDGF1 has a role in metachronous metastasis of colorectal cancer            \u003ca rel=\"nofollow\"\u003e             PMID:                        20126975            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TDGF-1, which is significantly upregulated in APA and mediates aldosterone hypersecretion and deregulated growth in adrenocortical cells in vitro, may represent a key player in the development and pathophysiology of primary aldosteronism.            \u003ca rel=\"nofollow\"\u003e             PMID:                        20385969            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Nodal and Cripto immunoreactivity increased dramatically in the transition from histologic Grade 1 to histologic Grades 2 and 3 endometrial carcinomas.            \u003ca rel=\"nofollow\"\u003e             PMID:                        19874624            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Cripto has dual roles as a coreceptor as well as a coligand for Nodal and that this signaling interaction with Nodal is regulated by an unusual form of glycosylation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        12052855            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects.            \u003ca rel=\"nofollow\"\u003e             PMID:                        12073012            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            complexation with activin and type II activin receptors and role in blocking activin signaling            \u003ca rel=\"nofollow\"\u003e             PMID:                        12682303            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CRIPTO signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        14581455            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results suggest that cripto-1 overexpression might be associated with the progression towards a more aggressive phenotype in breast carcinoma, through the activation of both Akt and Smad-2 signalling pathways.            \u003ca rel=\"nofollow\"\u003e             PMID:                        14584041            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The regulation of Netrin-1 expression is important in regulating Cripto-1-dependent invasion and migration of mammary epithelial cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        16176936            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The plasma CR-1 might represent a novel biomarker for the detection of breast and colon carcinomas. A statistically significant increase in the levels of plasma CR-1 was found in patients with colon carcinoma and in patients with breast carcinoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        16951234            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915055071457,"sku":"BL-0019NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLVmABhrVAACi3PNeapk099_abae2ec2-018f-4800-8055-3da806cb8499.jpg?v=1685851746"},{"product_id":"recombinant-mouse-bmp2k-protein-bl-0019sg","title":"Recombinant Mouse BMP2K Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eMouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_080708\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eBIKE; 4933417M22Rik; AA673486; AV128808\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eBMP2K or Bone morphogenic protein 2 inducible kinase is the human homolog of mouse BMP-2-inducible kinase which plays a key role in skeletal development and patterning. BMP2K is a serine\/threonine protein kinase which contains a nuclear localization signal and plays a regulatory role in attenuating the program of osteoblast differentiation. BMP2K gene is strongly correlated with high myopia and may contribute to a genetic risk factor for high degrees of myopic pathogenesis (1). BMP-2 expression is suppressed by an EP4 receptor antagonist and PGE2 produced by COX-2 increases BMP-2 expression via binding the EP4 receptor (2).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant mouse BMP2K (1-422) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e1-422\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e70 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Mouse BMP2K Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876839657697,"sku":"BL-0019SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-fgfr2-c491s-protein-bl-0037sg","title":"Recombinant Human FGFR2 (C491S) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eBC039243\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eK-SAM, BFR-1, CEK3, ECT1, TK14, TK25, CD332, JWS, TK14\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFGFR2 is a member of the fibroblast growth factor receptor family which play a role in mitogenesis and differentiation. FGFR2 is a high-affinity receptor for acidic, basic and\/or keratinocyte growth factor, and mutations in FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis (1). FGFR2 is required for early postimplantation development between implantation and the formation of the egg cylinder (2). FGFR2 contributes to the outgrowth, differentiation, and maintenance of the inner cell mass.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human FGFR2 (C491S) (285-end) was produced by baculovirus in Sf9 cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e285a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e~72 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human FGFR2 (C491S) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876847685857,"sku":"BL-0037SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-fgfr2-c491a-protein-bl-0038sg","title":"Recombinant Human FGFR2 (C491A) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eBC039243\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eK-SAM, BFR-1, CEK3, ECT1, TK14, TK25, CD332, JWS, TK14\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFGFR2 is a member of the fibroblast growth factor receptor family which play a role in mitogenesis and differentiation. FGFR2 is a high-affinity receptor for acidic, basic and\/or keratinocyte growth factor, and mutations in FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis (1). FGFR2 is required for early postimplantation development between implantation and the formation of the egg cylinder (2). FGFR2 contributes to the outgrowth, differentiation, and maintenance of the inner cell mass.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human FGFR2 (C491A) (285-end) was produced by baculovirus in Sf9 cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e285a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e~72 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human FGFR2 (C491A) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876847718625,"sku":"BL-0038SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-fgfr2-c491f-protein-bl-0039sg","title":"Recombinant Human FGFR2 (C491F) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eBC039243\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eK-SAM, BFR-1, CEK3, ECT1, TK14, TK25, CD332, JWS, TK14\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFGFR2 is a member of the fibroblast growth factor receptor family which play a role in mitogenesis and differentiation. FGFR2 is a high-affinity receptor for acidic, basic and\/or keratinocyte growth factor, and mutations in FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis (1). FGFR2 is required for early postimplantation development between implantation and the formation of the egg cylinder (2). FGFR2 contributes to the outgrowth, differentiation, and maintenance of the inner cell mass.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human FGFR2 (C491F) (285-end) was produced by baculovirus in Sf9 cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e285a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e~72 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human FGFR2 (C491F) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876847915233,"sku":"BL-0039SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-tgfbr2-protein-fc-tag-bl-0043np","title":"Recombinant Human TGFBR2 Protein (C-Fc)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Transforming Growth Factor-beta Receptor Type II is produced by our Mammalian expression system and the target gene encoding Thr23-Asp159 is expressed with a human IgG1 Fc tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eP37173\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTGF-beta receptor type-2; TGF-beta type II receptor;TGFBR2; Transforming growth factor-beta receptor type II\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTGFBR2 is a single-pass type I membrane protein and contains one protein kinase domain. TGFBR2 exsits as a heterodimeric complex with another receptor protein and binds TGF-beta. Signals triggered through the TGF-beta receptor complex prompt various responses by the cell. One such response is to inhibit cell growth and division. Based on this action, the TGF-beta receptor type 2 is sometimes called a tumor suppressor. Defects in TGFBR2 have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome and the development of various types of tumors.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e42.6 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e59 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eBiologically active. Please contact us to obtain bioactivity data.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg\/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTransmembrane serine\/threonine kinase forming with the TGF-beta type I serine\/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eCell membrane; Single-pass type I membrane protein. Membrane raft.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eProtein Families\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eProtein kinase superfamily, TKL Ser\/Thr protein kinase family, TGFB receptor subfamily\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            11773           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            133239           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:7048           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000351905           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        28443643            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            TGFBR2 Polymorphisms Are Associated with Colorectal Cancer in Patients with Lynch Syndrome.            \u003ca rel=\"nofollow\"\u003e             PMID:                        30275229            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study has confirmed or corrected the clinical diagnosis, and enlarged the mutation spectrum of FBN1 and TGFBR2 and confirmed that parental mosaicism may be the cause of the varied phenotypic expression of these connective tissue disorders.The results should be helpful for prenatal diagnosis and genetic counseling.            \u003ca rel=\"nofollow\"\u003e             PMID:                        30101859            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            the restoration of TGFBR2 in miR-204 overexpression Gastric cancer (GC) cells, which recovered resistance to 5-FU treatments compared with miR-204 overexpression GC cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29940566            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            MiR-9-5p promotes the proliferation, metastasis and invasion of non-small cell lung cancer cells by down-regulating TGFBR2 expression.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29239816            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Microarray-based analyses revealed that the expression of miR-20b was significantly increased, whereas TGFBR2 and MYC were significantly downregulated and upregulated, respectively, in all ES cells compared to their expression in human mesenchymal stem cells (hMSCs).            \u003ca rel=\"nofollow\"\u003e             PMID:                        29039480            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            this study provides evidence that TGFBR2 rs6785358 polymorphism might be associated with the risk of hypospadias.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28894026            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Down-regulation of TGF-beta RII was found in the invasive non-functioning pituitary adenomas compared to noninvasive ones.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29031543            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            findings reveal a novel role for miR-204\/ANGPT1\/TGFbetaR2 axis in tumor angiogenesis. We propose that therapeutic manipulation of miR-204 levels may represent a promising approach in breast cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27703260            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High TGFBR2 expression is associated with small cell lung cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28055980            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            expression induced by IL-6 in keratinocytes            \u003ca rel=\"nofollow\"\u003e             PMID:                        27892604            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            hsa-miR-1193 may be involved in sporadic colorectal cancer tumourigenesis at least in part by suppression of TGFBR2, and the A allele of rs11466537 disturbed the regulation of hsa-miR-1193 on TGFBR2.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28494187            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results show that TGFbR2 expression decreases in human gastric cancer (GC) tissue specimens and indicate that the expression of TGFbR2 is mainly dependent on post-transcriptional regulators in GC through miR-155 binding to the 3'-UTR of its mRNA.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29247570            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            This study demonstrated that Increased Transforming Growth Factor beta2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Abeta42 Load.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27911312            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data indicate the most significant gene level association seen with transforming growth factor beta receptor 2 (TGFBR2) and clear cell epithelial ovarian cancer (EOC).            \u003ca rel=\"nofollow\"\u003e             PMID:                        27533245            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Abnormal expression of TGF-beta type II receptor isoforms contributes to prognosis in acute myeloid leukemia.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28052022            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            altered Tgfbeta signaling in cultured mouse and human enteroids supports further the in vivo data and reveals a critical role for Tgfbeta signaling in generating precursor secretory cells. Overall, our data reveal a key role for Tgfbeta signaling in regulating ISCs clonal dynamics and differentiation, with implications for cancer, tissue regeneration, and inflammation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27791005            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            MiR-130 is up-regulated in gastric cancer (GC) tissues and directly targets TGF-beta type II receptor (TGFbetaR2).            \u003ca rel=\"nofollow\"\u003e             PMID:                        27304191            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA, thereby promoting gastric cancer cell growth and migration.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27120811            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High TGFBR2 expression is associated with mesenchymal to epithelial transition of breast cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28987542            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Inhibition of TGFBR2 had the similar effect as miR-9 overexpression.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27756824            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            we describe and characterize the functional impact of a novel VUS in the TGFBR2 kinase domain (c.1255G\u0026gt;T; p.Val419Leu), in a patient with the clinical diagnosis of Marfan syndrome spectrum. Our results establish that the V419L variant leads to aberrant TGF-beta signaling and confirm the diagnosis of Loeys-Dietz syndrome in this patient.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28679693            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Apo and inhibitor-bound TGFBR2 kinase structures are presented at high resolution (\u0026lt;2 A).            \u003ca rel=\"nofollow\"\u003e             PMID:                        27139629            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TGF-beta type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset PE. Endoglin was increased in both subtypes.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28633389            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            this is the first clinical report to demonstrate a potential causal association between TGFB2 gene mutations and aortic root dilatation in combination with the myxomatous degeneration of both atrioventricular valves.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28633253            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28182693            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            A novel mutation in the TGFBR2 gene was identified in a patient with Loeys-Dietz syndrome.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28344185            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            ZNF32 was found to directly bind to the TGF-betaR2 (transforming growth factor-beta receptor 2) promoter to promote its expression.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27763636            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High TGFBR2 expression is associated with glioma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28184932            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            these findings delineate the important function of the TGFbeta signaling pathway in the early development of kidney and TbetaRII was shown to be able to promote the expression of Six2 through Smad3 mediating transcriptional regulation and in turn activate the proliferation of MM cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28420207            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            YAP-1 promotes Tregs differentiation in hepatocellular carcinoma by enhancing TGFBR2 transcription.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28472799            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Gasdermin C is upregulated by inactivation of Tgfbr2 in the presence of mutated Apc, promoting colorectal cancer cell proliferation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27835699            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Depending on the TGFBR2 expression status of their donor cells, shed exosomes show distinct proteomic signatures and promote altered cytokine secretion profiles in recipient cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28376875            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            miR-520f inhibited tumor cell invasion by directly targeting ADAM9 and the TGFbeta receptor TGFBR2.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28209612            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Study demonstrated that the TGFBR2 mutation was not present in the sample of cervico-cerebral artery dissection patients (CCAD); however, a positive association was identified between the MTHFR-C677T polymorphism and genetically confirmed Mexican mestizo spontaneous CCAD patients            \u003ca rel=\"nofollow\"\u003e             PMID:                        27017342            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            A genetic investigation found a TGFbetaR2 gene mutation, leading to the diagnosis of Loeys-Dietz syndrome type2.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27017362            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results showed that transfection of CD34(+) cells with SiRNA targeting TGF-bRII and their co-culture with human bone marrow mesenchymal stromal cells (MSCs) could considerably increase the number of progenitors            \u003ca rel=\"nofollow\"\u003e             PMID:                        27344285            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Cell invasion (matrigel) was reduced only in the Hs578T cells (p \u0026lt; 0.01). Silencing decreased the expression of the prometastatic molecules S100A4 and TGFbetaR2 in both cell lines and CD44 in Hs578T cells. We conclude that ECM1 is a key player in the metastatic process and regulates the actin cytoskeletal architecture of aggressive breast cancer cells at least in part via alterations in S100A4 and Rho A.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27770373            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Our study uncovers a novel mechanism that miR-19a-3p\/19b-3p inhibits autophagy-mediated fibrogenesis by targeting TGF-beta R II.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27098600            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TGFBR2 signaling can affect Notch1 glycosylation via regulation of glycosyltransferase LFNG expression and provide a first mechanistic example for altered glycosylation in microsatellite instability colorectal tumor cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27156840            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            CD44 and TGFBR2 are the functional targets of miR-373, which are responsible for the tumor suppressive functions of miR-373            \u003ca rel=\"nofollow\"\u003e             PMID:                        26858153            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Polymorphism of TGFBR2 is associated with coronary artery disease.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27234600            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results found TGFBR2 to be significantly related to the regulated phosphoproteome in glioblastoma as a result of integrative upstream kinase\/ regulator analyses and experimentally validated as a novel regulator of glioblastoma stem cells.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26670566            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Reduced expression of TGF-beta type II receptor and extracellular matrix components in response to reduced fibroblast size\/mechanical force was fully reversed by restoring size\/mechanical force            \u003ca rel=\"nofollow\"\u003e             PMID:                        26780887            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            results suggested that high CDKN1A\/p21 and low TGFBR2 expression was closely correlated with adverse pathological parameters and poor prognosis in breast cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26823785            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Findings suggest that the upregulation of miR-590-5p promotes cellular malignant behavior via the target gene TGFbetaRII in vulvar squamous cell carcinoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26498065            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TGFBR2 is regulated by an epigenetic auto-feedback regulation in non-small cell lung cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26356817            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            we reported a sporadic Japanese case of LDS with a novel TGFBR2 p.Y424H mutation, which appeared to cause pregnancy-related fatal aortic\/arterial dissections.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26301661            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            AT2R downregulates the expression of TGF-betaRII in human proximal tubule cells            \u003ca rel=\"nofollow\"\u003e             PMID:                        26867007            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High levels of TbetaRII expression were associated with lymph node metastasis, increasing tumor clinical stage, and poorer 5-year disease-free survival in patients with breast cancer. TbetaRII may be a potential prognostic marker for breast cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26551005            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915099177185,"sku":"BL-0043NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLWyAFW1JAACsRky9aj0436_28cdafbc-d623-410f-aaec-a5439df7b650.jpg?v=1685853205"},{"product_id":"recombinant-human-tnfaip3-a20p37-protein-bl-0047sg","title":"Recombinant Human TNFAIP3 (A20p37) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHis\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_006290\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eAISBL, A20, OTUD7C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eTNFAIP3 (Tumor necrosis factor alpha-induced protein 3) is a ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. The enzyme plays a role in immune and inflammatory responses of cytokines such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through inhibiting NFkB activity (1). TNFAIP3 has been found to be associated with rheumatoid arthritis (2).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human TNFAIP3 (440-790 a.a.), or A20p37, was produced by baculovirus in Sf9 insect cells, fused with a His tag at N-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e440-790 a.a.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e41 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human TNFAIP3 (A20p37) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876849619169,"sku":"BL-0047SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-tweak-r-protein-fc-tag-bl-0058np","title":"Recombinant Human TWEAK R Protein (C-Fc)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human TNF-related Weak Inducer Of Apoptosis Receptor is produced by our Mammalian expression system and the target gene encoding Glu28-Trp79 is expressed with a human IgG1 Fc tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eQ9NP84\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; FN14; CD266 antigen and tweak-receptor\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTumor necrosis factor receptor superfamily member 12A(TNFRSF12A) is also known as Fibroblast growth factor-inducible immediate-early response protein 14, FN14, CD266 antigen and tweak-receptor. TNFRSF12A is a single-pass type I membrane protein, including a 27 aa signal peptide, a 53 aa extracellular domain, a 21 aa transmembrane domain and a 28 aa cytoplasmic domain. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A can be induced by FGF1 and phorbol ester. TNFRSF12A binds to TWEAK\/TNFSF12A to initiate a signal transduction cascade, causing different cellular responses such as cell death, cell proliferation, and angiogenesis.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e32.7 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e30-40 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e \u003ch3\u003eTarget Details\u003c\/h3\u003e\u003ctable width=\"100%\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eTarget Function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eReceptor for TNFSF12\/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSubcellular Location\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eMembrane; Single-pass type I membrane protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDatabase References\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003cdiv\u003e \u003cp\u003e           HGNC:           \u003ca rel=\"nofollow\"\u003e            18152           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           OMIM:           \u003ca rel=\"nofollow\"\u003e            605914           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           KEGG:           \u003ca rel=\"nofollow\"\u003e            hsa:51330           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           STRING:           \u003ca rel=\"nofollow\"\u003e            9606.ENSP00000326737           \u003c\/a\u003e \u003c\/p\u003e \u003cp\u003e           UniGene:           \u003ca rel=\"nofollow\"\u003e             PMID:                        29741404            \u003c\/a\u003e  \u003c\/p\u003e\n\u003cli\u003e            TWEAK\/Fn14 interaction induces proliferation and migration in human airway smooth muscle cells via activating the NF-kappaB pathway            \u003ca rel=\"nofollow\"\u003e             PMID:                        29143982            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data demonstrated that the Src\/Fn14\/NF-kappaB axis plays a critical role in NSCLC metastasis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29500337            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results show that Fn14 expression is high compared in non-small cell lung cancer compared to normal lung tissues. In addition, high Fn14 expression is associated with poor prognosis in lung adenocarcinoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29251323            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TWEAK\/Fn14 contributes to endothelial dysfunction through modulation of reactive oxygen species (ROS), and mitochondrial ROS.            \u003ca rel=\"nofollow\"\u003e             PMID:                        29257217            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Expression of the TWEAK-Fn14 axis was upregulated in patients with autoimmune thyroid disease and might play a role in the pathogenesis of autoimmune thyroid disease.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28636775            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data suggest that expression of Fn14 on a tumor can initiate cachexia; an antibody against Fn14 may be an effective antineoplastic agent. [REVIEW]            \u003ca rel=\"nofollow\"\u003e             PMID:                        27254081            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results suggest that TWEAK\/Fn14 interaction directly favors inorganic phosphate-induced vascular smooth muscle cells calcification by activation of both canonical and non-canonical NF-kappaB pathways.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27441657            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TWEAK upregulated the expression of Fn14.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28411440            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Fn14.TRAIL can be converted into a highly effective TRAIL oligomer upon binding to TWEAK which induces lymphoblast apoptosis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28455246            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Data show that aurintricarboxylic acid (ATA) targets the TNF-related WEAK inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling axis, which could potentially be developed as a new therapeutic agent for treatment of glioblastoma (GBM) patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28103571            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TNFRSF12A was knocked down in the SMMC7721 cell line through siRNA. This demonstrated that cells exhibited reduced reproductive and metastatic capacity ex vivo.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28138696            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            In this review article, we summarize studies indicating that (i) Fn14 gene expression is low in normal brain tissue but is upregulated in advanced brain cancers and, in particular, in GB tumors ; TWEAK: Fn14 engagement as well as Fn14 overexpression can stimulate glioma cell migration, invasion and resistance to chemotherapeutic agents in vitro.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26300004            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Fn14 is a receptor of mitogen TWEAK (tumor necrosis factor-like weak inducer of apoptosis), expressed on the membranes of HPCs and promoting their proliferation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        28180936            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            EGFR Del 19 may promote Fn14 and JAK1\/STAT1 expression in NSCLC.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27350337            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TWEAK\/Fn14 activation induces keratinocyte proliferation under psoriatic inflammation            \u003ca rel=\"nofollow\"\u003e             PMID:                        26264384            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The results demonstrated that vitreous fluid from patients with PDR had higher levels of TWEAK and Fn14 than that from T2DM patients without PDR, thus suggesting an important regulatory role of TWEAK\/Fn14 signaling in the pathogenesis of PDR.            \u003ca rel=\"nofollow\"\u003e             PMID:                        27051016            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results indicate that FN14 and GRP94 are prediction\/prognosis markers which open up new possibilities for preventing\/treating brain metastasis in breast cancer patients.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26497551            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Evidence that higher tumor Fn14 expression is required for pharmacodynamic response to the anti-TWEAK monoclonal antibody RG7212 in patients with Fn14-positive solid tumors.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26446946            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Fn14 has multiple roles in tumor metastasis. (Review)            \u003ca rel=\"nofollow\"\u003e             PMID:                        26592249            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TWEAK\/Fn14 interaction promotes oxidative stress through NADPH oxidase activation in macrophages.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26224570            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Activated Fn14 expression increases extracellular matrix synthesis and fibroblast activation. Activation of Fn14 is done by the TGF-beta signaling pathway through the transcription factor SMAD4.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26625141            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Fn14 modulates cell growth and drug resistance by upregulating Bcl-xl expression through the NF-kappaB pathway.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25054270            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results indicate that oncogenic Src may contribute to Fn14 overexpression in solid tumors, and that Src mediated cell invasion could potentially be inhibited with Fn14- targeted therapeutics.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25392346            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            HPV type 16 infections keratinocytes turns from apoptosis to proliferation cycle under FN14 protein influence.            \u003ca rel=\"nofollow\"\u003e             PMID:                        26016896            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The first human data to show a transient activation of the TWEAK-Fn14 axis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        25539934            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TWEAK-Fn14 axis may be involved in the pathogenesis of polymyositis and dermatomyositis            \u003ca rel=\"nofollow\"\u003e             PMID:                        24467773            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TweakR protein was expressed in about half of human breast cancer samples            \u003ca rel=\"nofollow\"\u003e             PMID:                        25375638            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            abundantly expressed in the dermal vessel wall of lesional skin in patients with urticarial vasculitis but not controls            \u003ca rel=\"nofollow\"\u003e             PMID:                        23968277            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Results position TWEAK-Fn14 signaling through Mcl-1 as a significant mechanism for NSCLC tumor cell survival            \u003ca rel=\"nofollow\"\u003e             PMID:                        24469836            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            results define one upstream mechanism, via FN14 signaling, through which the NFkappaB pathway contributes to prostate cancer metastasis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24970477            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Receptor-targeted therapeutics for both MET and FN14 are in clinical development, the use of which may mitigate the metastatic potential of NSCLC.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24710956            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            insight into the Fn14 signaling mechanism            \u003ca rel=\"nofollow\"\u003e             PMID:                        23750247            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            High FN14 expression is associated with resistance to 5-fluorouracil in gastric cancer.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24337061            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            a model in which constitutive down-regulation of Fn14 facilitates dynamic regulation of Fn14 protein levels and prevents spontaneous or inappropriate receptor signaling.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24652288            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            We found that the TNF-like weak inducer of apoptosis (TWEAK)\/fibroblast growth factor inducible-14 (Fn14) pathway is involved in the development of pathologic retinal neovascularization.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24408972            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            These new findings of the effect of Fn14 on valvular interstitial cell-like differentiation may provide a novel therapeutic strategy for heart valve disease treatment.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24122208            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Increased podocyte Fn14 expression is associated with proteinuric kidney disease.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23999007            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Fn14 overexpression is associated with hepatocellular carcinoma.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23886137            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Induced overexpression of Fn14 levels in MCF7 cells through HER2 (ERBB2) signaling translated to an improved therapeutic index of hSGZ treatment.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23722548            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Fn14 protein may have a role in breast carcinoma progression            \u003ca rel=\"nofollow\"\u003e             PMID:                        23300011            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            results validate the TWEAK-Fn14 interaction as a chemically tractable target and provide the foundation for further exploration utilizing chemical biology approaches focusing on validating this system as a therapeutic target in invasive cancers.            \u003ca rel=\"nofollow\"\u003e             PMID:                        24056367            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The Fn14\/TWEAK pathway contributes to the endothelial steps of neuroinflammation.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23320797            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            The expression of TWEAK and Fn14 in neuroblastoma suggests that TWEAK functions as an important regulator of primary neuroblastoma growth, invasion and survival.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23443741            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TWEAK\/Fn14, by activating macrophages, could be ovarian tumor suppressors.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23469193            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            we show that TWEAK\/Fn14 can signal through the JAK-STAT pathway to induce interferon-beta, and that the ability of TWEAK to induce tumor cell apoptosis is mediated by JAK-STAT signaling.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23107828            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TWEAK binds to hFn14 by surface plasmon resonance (View interaction) xeFn14 binds to TWEAK by enzyme linked immunosorbent assay            \u003ca rel=\"nofollow\"\u003e             PMID:                        23438059            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            LCN2 and TWEAKR-TWEAK as crucial downstream effectors of NFAT1 that regulate breast cancer cell motility and invasive capacity.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22767506            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            Fn14, the receptor for TNF-like weak inducer of apoptosis, is selectively upregulated in patients with Alcoholic Hepatitis.            \u003ca rel=\"nofollow\"\u003e             PMID:                        22637703            \u003c\/a\u003e \u003c\/li\u003e \u003cli\u003e            TWEAK\/Fn14 can regulate expression and secretion of HMGB1 in monocytes\/macrophages, participating in the inflammatory response associated with atherosclerotic plaque development.            \u003ca rel=\"nofollow\"\u003e             PMID:                        23288170            \u003c\/a\u003e \u003c\/li\u003e \u003c\/div\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915066343649,"sku":"BL-0058NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLbuAQlgNAADJy_2Hyy0727_0263e8c8-6490-4dcc-a54b-5f8facb5422b.jpg?v=1685852038"},{"product_id":"recombinant-human-egfr-l718q-t790m-l858r-protein-bl-0069sg","title":"Recombinant Human EGFR (L718Q T790M L858R) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (L718Q T790M L858R) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (L718Q T790M L858R) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876854239457,"sku":"BL-0069SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-egfr-t790m-l792f-l858r-protein-bl-0070sg","title":"Recombinant Human EGFR (T790M L792F L858R) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (T790M L792F L858R) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (T790M L792F L858R) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876854337761,"sku":"BL-0070SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-mouse-tweak-r-protein-fc-tag-bl-0071np","title":"Recombinant Mouse TWEAK R Protein (C-Fc)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Mouse TNF-related Weak Inducer Of Apoptosis Receptor is produced by our Mammalian expression system and the target gene encoding Glu28-Trp79 is expressed with a human IgG1 Fc tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003ca title=\"Q9CR75\" target=\"_blank\" href=\"https:\/\/www.uniprot.org\/uniprotkb\/Q9CR75\/entry\"\u003eQ9CR75\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTumor necrosis factor receptor superfamily member 12A;Fibroblast growth factor-inducible immediate-early response protein 14;Fibroblast growth factor-regulated protein 2;Tweak-receptor;TweakR;TNFRSF12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eTumor necrosis factor receptor superfamily member 12A(Tnfrsf12a) is a single-pass type I membrane protein and contains 1 TNFR-Cys repeat. It is weak inducer of apoptosis in some cell types.It promotes angiogenesis and it is the proliferation of endothelial cells. It may modulate cellular adhesion to matrix proteins.TNFR binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors. TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. It plays an important role in the inflammatory processes of rheumatoid arthritis (RA), polyarticular-course juvenile rheumatoid arthritis (JRA), and ankylosing spondylitis and the resulting joint pathology. In addition, TNF plays a role in the inflammatory process of plaque psoriasis. Elevated levels of TNF are found in involved tissues and fluids of patients with RA, psoriatic arthritis, ankylosing spondylitis (AS), and plaque psoriasis. Two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75), exist naturally as monomeric molecules on cell surfaces and in soluble forms. Biological activity of TNF is dependent upon binding to either cell surface TNFR.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e32.6 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e30-40 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 95% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915081187553,"sku":"BL-0071NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLb2AJr5IAAClW9YQp88660_34c9c6c9-59a7-4d6f-b86e-cb79272f4dab.jpg?v=1685852474"},{"product_id":"recombinant-human-egfr-t790m-l792h-l858r-protein-bl-0071sg","title":"Recombinant Human EGFR (T790M L792H L858R) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (T790M L792H L858R) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (T790M L792H L858R) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876854403297,"sku":"BL-0071SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-egfr-l792f-l858r-protein-bl-0072sg","title":"Recombinant Human EGFR (L792F L858R) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (L792F L858R) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (L792F L858R) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876854763745,"sku":"BL-0072SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-egfr-l792f-protein-bl-0073sg","title":"Recombinant Human EGFR (L792F) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (L792F) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (L792F) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876854993121,"sku":"BL-0073SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-egfr-k728a-t790m-c797s-l858r-protein-bl-0074sg","title":"Recombinant Human EGFR (K728A T790M C797S L858R) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (K728A T790M C797S L858R) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (K728A T790M C797S L858R) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876855386337,"sku":"BL-0074SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-egfr-l792h-c797s-l858r-protein-bl-0075sg","title":"Recombinant Human EGFR (L792H C797S L858R) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (L792H C797S L858R) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (L792H C797S L858R) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876856533217,"sku":"BL-0075SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-egfr-t790m-l792h-c797s-l858r-protein-bl-0076sg","title":"Recombinant Human EGFR (T790M L792H C797S L858R) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (T790M L792H C797S L858R) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (T790M L792H C797S L858R) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876858400993,"sku":"BL-0076SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-egfr-t790m-l792f-c797s-l858r-protein-bl-0077sg","title":"Recombinant Human EGFR (T790M L792F C797S L858R) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (T790M L792F C797S L858R) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (T790M L792F C797S L858R) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876858794209,"sku":"BL-0077SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-egfr-t790m-c797s-l858r-r999a-protein-bl-0078sg","title":"Recombinant Human EGFR (T790M C797S L858R R999A) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (T790M C797S L858R R999A) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (T790M C797S L858R R999A) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876859023585,"sku":"BL-0078SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-egfr-r999a-protein-bl-0079sg","title":"Recombinant Human EGFR (R999A) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (R999A) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (R999A) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876859089121,"sku":"BL-0079SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-egfr-l792h-protein-bl-0080sg","title":"Recombinant Human EGFR (L792H) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (L792H) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (L792H) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876859515105,"sku":"BL-0080SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-egfr-k716a-c797s-l858r-protein-bl-0081sg","title":"Recombinant Human EGFR (K716A C797S L858R) Protein","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 data-mce-fragment=\"1\" class=\"font_9\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eGST\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eHost Species\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eNM_005228\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eERBB, mENA, ERBB1, HER1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eEGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant human EGFR (K716A C797S L858R) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.  This protein is purified with our unique purification methods.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eSource\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eSf9 insect cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eAA Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e668a.a.-end\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e89~100 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor specific purity information on a given lot, see related COA.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eBioactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eActive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eThe recombinant protein is stable for up to 12 months at -70°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\" data-mce-style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\" data-mce-style=\"width: 70%;\"\u003eRecombinant Human EGFR (K716A C797S L858R) Protein should be stored should be stored at \u0026lt; -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"Default Title","offer_id":42876859580641,"sku":"BL-0081SG","price":0.0,"currency_code":"USD","in_stock":true}]},{"product_id":"recombinant-human-ctgf-protein-fc-tag-bl-0082np","title":"Recombinant Human CTGF Protein (C-Fc)","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003ch3 class=\"font_9\"\u003e\n\u003cspan\u003eProduct Overview\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eRecombinant Human Connective Tissue Growth Factor is produced by our Mammalian expression system and the target gene encoding Gln27-Ala349 is expressed with a human IgG1 Fc tag at the C-terminus.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e\u003ca title=\"Q5M8T4\" target=\"_blank\" href=\"https:\/\/www.uniprot.org\/uniprotkb\/Q5M8T4\/entry\"\u003eQ5M8T4\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eSynonym\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eConnective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; CTGF; IGFBP8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eGene Background\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eCTGF belongs to the CCN (CTGF\/Cyr61\/Cef10\/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF causes a variety of cellular responses including reduced cell adhesion and enhanced cell migration and proliferation. CTGF has also been shown to be essential for epithelial to mesenchymal transition (EMT), a process whereby normal functioning cells morph into ones that produce mainly scar tissue (of which collagen in the major protein component).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eMolecular Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e62.6 KDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eApmol Mass\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003e67-81 KDa, reducing conditions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLess than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eGreater than 90% as determined by reducing SDS-PAGE. (QC verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eBiological Activity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eNot tested\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eAlways centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg\/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eLyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eShipping\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003e\u003cstrong\u003eUsage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 70%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Beta LifeScience","offers":[{"title":"10μg","offer_id":43915017322721,"sku":"BL-0082NP","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/products\/CgAKNmLkLYeAJ7WJAAC4Mk8mTnc829_0d65aa7f-4e50-43c1-8a4c-fed1db61ee10.jpg?v=1685850626"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0624\/2169\/6737\/collections\/Cytokines.jpg?v=1759825067","url":"https:\/\/www.betalifesci.com\/collections\/cytokines-chemokines-and-growth-factors.oembed?page=10","provider":"Beta LifeScience","version":"1.0","type":"link"}